Impact of HLA-B alleles, epitope binding affinity, functional avidity, and viral coinfection on the immunodominance of virus-specific CTL responses.
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Increased Cytotoxic T-Lymphocyte Epitope Variant Cross-Recognition and Functional Avidity Are Associated with Hepatitis C Virus ClearanceAntigen processing influences HIV-specific cytotoxic T lymphocyte immunodominanceCTL responses of high functional avidity and broad variant cross-reactivity are associated with HIV controlRecognition of HIV-1 peptides by host CTL is related to HIV-1 similarity to human proteins.HLA class I supertypes: a revised and updated classification.Phylogenetic dependency networks: inferring patterns of CTL escape and codon covariation in HIV-1 Gag.Epitope mapping of HIV-specific CD8+ T cells in a cohort dominated by clade A1 infection.Generation of robust CD8+ T-cell responses against subdominant epitopes in conserved regions of HIV-1 by repertoire mining with mimotopes.Novel, in-natural-infection subdominant HIV-1 CD8+ T-cell epitopes revealed in human recipients of conserved-region T-cell vaccinesViral adaptation to immune selection pressure by HLA class I-restricted CTL responses targeting epitopes in HIV frameshift sequences.POPISK: T-cell reactivity prediction using support vector machines and string kernels.Additive contribution of HLA class I alleles in the immune control of HIV-1 infection.Monofunctional and polyfunctional CD8+ T cell responses to human herpesvirus 8 lytic and latency proteins.Immunodominant HIV-1-specific HLA-B- and HLA-C-restricted CD8+ T cells do not differ in polyfunctionality.Estimating the fitness cost of escape from HLA presentation in HIV-1 protease and reverse transcriptase.Autologous HIV-1 clade-B Nef peptides elicit increased frequency, breadth and function of CD8+ T-cells compared to consensus peptides.Use of RT-defective HIV virions: new tool to evaluate specific response in chronic asymptomatic HIV-infected individualsAlternative effector-function profiling identifies broad HIV-specific T-cell responses in highly HIV-exposed individuals who remain uninfected.Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover.Reappraisal of the relationship between the HIV-1-protective single-nucleotide polymorphism 35 kilobases upstream of the HLA-C gene and surface HLA-C expression.A panel of artificial APCs expressing prevalent HLA alleles permits generation of cytotoxic T cells specific for both dominant and subdominant viral epitopes for adoptive therapy.High-functional-avidity cytotoxic T lymphocyte responses to HLA-B-restricted Gag-derived epitopes associated with relative HIV controlInsights into HLA-restricted T cell responses in a novel mouse model of dengue virus infection point toward new implications for vaccine design.HLA class I allele promiscuity revisited.Variable processing and cross-presentation of HIV by dendritic cells and macrophages shapes CTL immunodominance and immune escape.Clonotype and repertoire changes drive the functional improvement of HIV-specific CD8 T cell populations under conditions of limited antigenic stimulation.CMV reactivation drives posttransplant T-cell reconstitution and results in defects in the underlying TCRβ repertoireDefinition of the viral targets of protective HIV-1-specific T cell responsesLytic and latent antigens of the human gammaherpesviruses Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus induce T-cell responses with similar functional properties and memory phenotypesMamu-B*08-positive macaques control simian immunodeficiency virus replicationSkewed association of polyfunctional antigen-specific CD8 T cell populations with HLA-B genotypeEpitope targeting and viral inoculum are determinants of Nef-mediated immune evasion of HIV-1 from cytotoxic T lymphocytesPortable flanking sequences modulate CTL epitope processing.The impact of HLA class I and EBV latency-II antigen-specific CD8(+) T cells on the pathogenesis of EBV(+) Hodgkin lymphomaPatterns of CD8+ immunodominance may influence the ability of Mamu-B*08-positive macaques to naturally control simian immunodeficiency virus SIVmac239 replication.Relative Resistance of HLA-B to Downregulation by Naturally Occurring HIV-1 Nef Sequences.Cytotoxic polyfunctionality maturation of cytomegalovirus-pp65-specific CD4 + and CD8 + T-cell responses in older adults positively correlates with response size.High-dimensional immunomonitoring models of HIV-1-specific CD8 T-cell responses accurately identify subjects achieving spontaneous viral control.Availability of a diversely avid CD8+ T cell repertoire specific for the subdominant HLA-A2-restricted HIV-1 Gag p2419-27 epitopePatterns of antigenic diversity and the mechanisms that maintain them
P2860
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P2860
Impact of HLA-B alleles, epitope binding affinity, functional avidity, and viral coinfection on the immunodominance of virus-specific CTL responses.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh-hant
name
Impact of HLA-B alleles, epito ...... virus-specific CTL responses.
@en
Impact of HLA-B alleles, epito ...... virus-specific CTL responses.
@nl
type
label
Impact of HLA-B alleles, epito ...... virus-specific CTL responses.
@en
Impact of HLA-B alleles, epito ...... virus-specific CTL responses.
@nl
prefLabel
Impact of HLA-B alleles, epito ...... virus-specific CTL responses.
@en
Impact of HLA-B alleles, epito ...... virus-specific CTL responses.
@nl
P2093
P50
P1476
Impact of HLA-B alleles, epito ...... virus-specific CTL responses.
@en
P2093
Bette T Korber
Caitlyn H Linde
Eunice Pae
Florian Bihl
Hannah S Hewitt
John Sidney
John V Chisholm
Kaori Sango
Karina Yusim
Leah Henry
P304
P356
10.4049/JIMMUNOL.176.7.4094
P407
P577
2006-04-01T00:00:00Z