Analytical method for simultaneously measuring ex vivo drug receptor occupancy and dissociation rate: application to (R)-dimethindene occupancy of central histamine H1 receptors.
about
Quantitative pharmacological analysis of antagonist binding kinetics at CRF1 receptors in vitro and in vivoChronic sazetidine-A at behaviorally active doses does not increase nicotinic cholinergic receptors in rodent brain.Radioligand dissociation measurements: potential interference of rebinding and allosteric mechanisms and physiological relevance of the biological model systems.Rebinding: or why drugs may act longer in vivo than expected from their in vitro target residence time.Drug-target residence time--a case for G protein-coupled receptors.Estimation of the dissociation rate of unlabelled ligand-receptor complexes by a 'two-step' competition binding approach.Characterization of Kinetic Binding Properties of Unlabeled Ligands via a Preincubation Endpoint Binding Approach.A two-state model for the kinetics of competitive radioligand binding.
P2860
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P2860
Analytical method for simultaneously measuring ex vivo drug receptor occupancy and dissociation rate: application to (R)-dimethindene occupancy of central histamine H1 receptors.
description
2009 nî lūn-bûn
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2009年の論文
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2009年学术文章
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2009年学术文章
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2009年学术文章
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2009年学术文章
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2009年学术文章
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2009年學術文章
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name
Analytical method for simultan ...... entral histamine H1 receptors.
@en
Analytical method for simultan ...... sociation rate: application to
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type
label
Analytical method for simultan ...... entral histamine H1 receptors.
@en
Analytical method for simultan ...... sociation rate: application to
@nl
prefLabel
Analytical method for simultan ...... entral histamine H1 receptors.
@en
Analytical method for simultan ...... sociation rate: application to
@nl
P2093
P2860
P1476
Analytical method for simultan ...... central histamine H1 receptors
@en
P2093
Paul D Crowe
Sam R J Hoare
Siobhan Malany
William F Smith
P2860
P356
10.1080/10799890902721339
P577
2009-01-01T00:00:00Z