Quantifying the association and dissociation rates of unlabelled antagonists at the muscarinic M3 receptor.
about
Long-lasting target binding and rebinding as mechanisms to prolong in vivo drug actionLigand binding assays at equilibrium: validation and interpretationStructure and dynamics of the M3 muscarinic acetylcholine receptorNew approaches for the reliable in vitro assessment of binding affinity based on high-resolution real-time data acquisition of radioligand-receptor binding kineticsEstimation of binding rate constants using a simultaneous mixed-effects method: application to monoamine transporter reuptake inhibitor reboxetineMuscarinic receptor antagonists: effects on pulmonary function.The effect of allosteric modulators on the kinetics of agonist-G protein-coupled receptor interactions in single living cells.Quantitative pharmacological analysis of antagonist binding kinetics at CRF1 receptors in vitro and in vivoModified T4 Lysozyme Fusion Proteins Facilitate G Protein-Coupled Receptor Crystallogenesis.Pharmacological characterization of GSK1004723, a novel, long-acting antagonist at histamine H(1) and H(3) receptorsBiosensor-based affinities and binding kinetics of small molecule antagonists to the adenosine A(2A) receptor reconstituted in HDL like particles.Characterization of 12 GnRH peptide agonists - a kinetic perspectiveLong lasting MDM2/Translocator protein modulator: a new strategy for irreversible apoptosis of human glioblastoma cells.Rebinding: or why drugs may act longer in vivo than expected from their in vitro target residence time.Allosteric interactions at adenosine A(1) and A(3) receptors: new insights into the role of small molecules and receptor dimerization.Drug-target residence time--a case for G protein-coupled receptors.The Role of Target Binding Kinetics in Drug Discovery.Kv 11.1 (hERG)-induced cardiotoxicity: a molecular insight from a binding kinetics study of prototypical Kv 11.1 (hERG) inhibitors.Dual-point competition association assay: a fast and high-throughput kinetic screening method for assessing ligand-receptor binding kinetics.Estimation of the dissociation rate of unlabelled ligand-receptor complexes by a 'two-step' competition binding approach.Non-equivalence of Key Positively Charged Residues of the Free Fatty Acid 2 Receptor in the Recognition and Function of Agonist Versus Antagonist Ligands.Binding kinetics differentiates functional antagonism of orexin-2 receptor ligands.Functional efficacy of adenosine A₂A receptor agonists is positively correlated to their receptor residence timeSlow receptor dissociation is not a key factor in the duration of action of inhaled long-acting β2-adrenoceptor agonistsTiotropium increases cytosolic muscarinic M3 receptors and acetylated H3 histone proteins in induced sputum cells of COPD patients.Analytical method for simultaneously measuring ex vivo drug receptor occupancy and dissociation rate: application to (R)-dimethindene occupancy of central histamine H1 receptors.Molecular Basis of Ligand Dissociation from G Protein-Coupled Receptors and Predicting Residence Time.Competition radioligand binding assays for the investigation of bispyridinium compound affinities to the human muscarinic acetylcholine receptor subtype 5 (hM(5) ).Characterization of Kinetic Binding Properties of Unlabeled Ligands via a Preincubation Endpoint Binding Approach.Measuring receptor target coverage: a radioligand competition binding protocol for assessing the association and dissociation rates of unlabeled compounds.Miniaturized receptor binding assays: complications arising from ligand depletion.A two-state model for the kinetics of competitive radioligand binding.Basic and modern concepts on cholinergic receptor: A review
P2860
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P2860
Quantifying the association and dissociation rates of unlabelled antagonists at the muscarinic M3 receptor.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Quantifying the association an ...... at the muscarinic M3 receptor.
@en
Quantifying the association an ...... at the muscarinic M3 receptor.
@nl
type
label
Quantifying the association an ...... at the muscarinic M3 receptor.
@en
Quantifying the association an ...... at the muscarinic M3 receptor.
@nl
prefLabel
Quantifying the association an ...... at the muscarinic M3 receptor.
@en
Quantifying the association an ...... at the muscarinic M3 receptor.
@nl
P2860
P356
P1476
Quantifying the association an ...... at the muscarinic M3 receptor
@en
P2093
Mark R Dowling
P2860
P304
P356
10.1038/SJ.BJP.0706819
P407
P577
2006-07-10T00:00:00Z