Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease. - Wikidata - wikimedia - TriplyDB

Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease.

Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease.

http://www.wikidata.org/entity/Q46150192

about

Actin in dendritic spines: connecting dynamics to function Mechanisms of synapse and dendrite maintenance and their disruption in psychiatric and neurodegenerative disorders Signaling effect of amyloid-beta(42) on the processing of AbetaPP GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo Regulation of the Postsynaptic Compartment of Excitatory Synapses by the Actin Cytoskeleton in Health and Its Disruption in Disease Mouse Genetic Models of Human Brain Disorders Abnormal kalirin signaling in neuropsychiatric disorders.Protein prenylation and synaptic plasticity: implications for Alzheimer's disease The Beta-amyloid protein of Alzheimer's disease: communication breakdown by modifying the neuronal cytoskeleton Amyloid β precursor protein as a molecular target for amyloid β--induced neuronal degeneration in Alzheimer's disease Rho family GTPases: key players in neuronal development, neuronal survival, and neurodegeneration p21-Activated kinase inhibitors: a patent review PAK in Alzheimer disease, Huntington disease and X-linked mental retardation A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease PAKs inhibitors ameliorate schizophrenia-associated dendritic spine deterioration in vitro and in vivo during late adolescence.p21-activated kinase-aberrant activation and translocation in Alzheimer disease pathogenesis Actin-binding protein drebrin E is involved in junction dynamics during spermatogenesis Shank3 deficiency induces NMDA receptor hypofunction via an actin-dependent mechanism Synaptic activity prompts gamma-secretase-mediated cleavage of EphA4 and dendritic spine formation Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486.Dendritic spine pathology in neuropsychiatric disorders Propagation of tau pathology in a model of early Alzheimer's disease PAK-PIX interactions regulate adhesion dynamics and membrane protrusion to control neurite outgrowth.Mapping of drebrin binding site on F-actin.Matrix-specific protein kinase A signaling regulates p21-activated kinase activation by flow in endothelial cells Cytoskeletal pathologies of Alzheimer disease Developmental vulnerability of synapses and circuits associated with neuropsychiatric disorders.Dendritic Spines: Similarities with Protrusions and Adhesions in Migrating Cells p21-activated kinase signaling regulates oxidant-dependent NF-kappa B activation by flow.Blocking p21-activated kinase reduces lipopolysaccharide-induced acute lung injury by preventing polymorphonuclear leukocyte infiltration.Matrix-specific p21-activated kinase activation regulates vascular permeability in atherogenesis.Pivotal role of the RanBP9-cofilin pathway in Aβ-induced apoptosis and neurodegeneration.GSK3 inhibitors show benefits in an Alzheimer's disease (AD) model of neurodegeneration but adverse effects in control animals Slingshot-Cofilin activation mediates mitochondrial and synaptic dysfunction via Aβ ligation to β1-integrin conformers.Mapping cofilin-actin rods in stressed hippocampal slices and the role of cdc42 in amyloid-beta-induced rods.Light exposure before learning improves memory consolidation at night The modular systems biology approach to investigate the control of apoptosis in Alzheimer's disease neurodegeneration.PAK inactivation impairs social recognition in 3xTg-AD Mice without increasing brain deposition of tau and Aβ Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease.Intercellular protein-protein interactions at synapses.

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Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease.

http://www.wikidata.org/entity/Q46150192

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Role of p21-activated kinase p ...... deficits of Alzheimer disease.

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Role of p21-activated kinase p ...... deficits of Alzheimer disease.

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Role of p21-activated kinase p ...... deficits of Alzheimer disease.

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Role of p21-activated kinase p ...... deficits of Alzheimer disease.

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Nature Neuroscience

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Role of p21-activated kinase p ...... deficits of Alzheimer disease

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Bruce Teter

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Fusheng Yang

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Giselle P Lim

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Greg M Cole

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James E Hansen

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Lixia Zhao

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Marni E Harris-White

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Oliver J Ubeda

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Qiu-Lan Ma

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Richard H Weisbart

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P2860

Rho proteins, mental retardation and the cellular basis of cognition

Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome

The ADF homology (ADF-H) domain: a highly exploited actin-binding module

Cofilin changes the twist of F-actin: implications for actin filament dynamics and cellular function

The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity

Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I

Nuclear localization and chromatin targets of p21-activated kinase 1

Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization

PAK3 mutation in nonsyndromic X-linked mental retardation

Disappearance of actin-binding protein, drebrin, from hippocampal synapses in Alzheimer's disease

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Alzheimer's disease