Induced structure of a helical switch as a mechanism to regulate enzymatic activity.
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Current and potential treatments for ubiquitous but neglected herpesvirus infectionsSubstrate Modulation of Enzyme Activity in the Herpesvirus Protease FamilyEnzyme Inhibition by Allosteric Capture of an Inactive ConformationDesigning Allosteric Control into Enzymes by Chemical Rescue of StructureBroad-Spectrum Allosteric Inhibition of Herpesvirus ProteasesDimerization-Induced Allosteric Changes of the Oxyanion-Hole Loop Activate the Pseudorabies Virus Assemblin pUL26N, a Herpesvirus Serine ProteaseMaking molecular machines workTrapping moving targets with small molecules.Inhibition of a viral enzyme by a small-molecule dimer disruptor.A screening strategy for trapping the inactive conformer of a dimeric enzyme with a small molecule inhibitor.Enzymatic activities of human cytomegalovirus maturational protease assemblin and its precursor (pPR, pUL80a) are comparable: [corrected] maximal activity of pPR requires self-interaction through its scaffolding domain.Fragment-Based Protein-Protein Interaction Antagonists of a Viral Dimeric ProteaseA thermodynamic definition of protein domainsThe active-inactive transition of human thymidylate synthase: Targeted molecular dynamics simulations
P2860
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P2860
Induced structure of a helical switch as a mechanism to regulate enzymatic activity.
description
2005 nî lūn-bûn
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2005年の論文
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name
Induced structure of a helical switch as a mechanism to regulate enzymatic activity.
@en
Induced structure of a helical switch as a mechanism to regulate enzymatic activity.
@nl
type
label
Induced structure of a helical switch as a mechanism to regulate enzymatic activity.
@en
Induced structure of a helical switch as a mechanism to regulate enzymatic activity.
@nl
prefLabel
Induced structure of a helical switch as a mechanism to regulate enzymatic activity.
@en
Induced structure of a helical switch as a mechanism to regulate enzymatic activity.
@nl
P2093
P2860
P356
P1476
Induced structure of a helical switch as a mechanism to regulate enzymatic activity.
@en
P2093
Alan B Marnett
Anson M Nomura
Charles S Craik
Nobuhisa Shimba
P2860
P2888
P304
P356
10.1038/NSMB1006
P577
2005-11-01T00:00:00Z
P5875
P6179
1040648861