The death effector domain of PEA-15 is involved in its regulation of integrin activation.
about
Integrin activation by Fam38A uses a novel mechanism of R-Ras targeting to the endoplasmic reticulumIdentification and characterization of DEDD2, a death effector domain-containing proteinPEA-15 facilitates EGFR dephosphorylation via ERK sequestration at increased ER-PM contacts in TNBC cellsPhosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADDAn Eph receptor regulates integrin activity through R-RasPhysical mapping of genes in somatic cell radiation hybrids by comparative genomic hybridization to cDNA microarrays.Recognition of ERK MAP kinase by PEA-15 reveals a common docking site within the death domain and death effector domainRegulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with themDifferential gene expression by endothelial cells in distinct angiogenic statesR-Ras contains a proline-rich site that binds to SH3 domains and is required for integrin activation by R-RasRSK2 activity is regulated by its interaction with PEA-15Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIICCrk activation of JNK via C3G and R-RasARF-GEF cytohesin-2/ARNO regulates R-Ras and α5-integrin recycling through an EHD1-positive compartmentAn experimentally derived database of candidate Ras-interacting proteins.PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastomaRSK2 protein suppresses integrin activation and fibronectin matrix assembly and promotes cell migrationERK MAP kinase is targeted to RSK2 by the phosphoprotein PEA-15.RACK1 regulates integrin-mediated adhesion, protrusion, and chemotactic cell migration via its Src-binding sitePEA-15 unphosphorylated at both serine 104 and serine 116 inhibits ovarian cancer cell tumorigenicity and progression through blocking β-catenin.Identification of cell signaling molecules by expression cloning.R-Ras regulates migration through an interaction with filamin A in melanoma cells.Suppression of integrin activation by activated Ras or Raf does not correlate with bulk activation of ERK MAP kinase.Differential roles of Akt, Rac, and Ral in R-Ras-mediated cellular transformation, adhesion, and survival.Phosphoprotein enriched in astrocytes (PEA)-15: a potential therapeutic target in multiple disease states.Mammalian NOTCH-1 activates beta1 integrins via the small GTPase R-Ras.Death effector domain protein PEA-15 potentiates Ras activation of extracellular signal receptor-activated kinase by an adhesion-independent mechanismA phospholipase Cγ1-activated pathway regulates transcription in human vascular smooth muscle cells.Akt down-regulates ERK1/2 nuclear localization and angiotensin II-induced cell proliferation through PEA-15.The integrin-linked kinase-PINCH-parvin complex supports integrin αIIbβ3 activation.Phosphoprotein enriched in astrocytes-15 kDa expression inhibits astrocyte migration by a protein kinase C delta-dependent mechanismClassifying ten types of major cancers based on reverse phase protein array profiles.PEA-15 modulates TNFalpha intracellular signaling in astrocytes.High ERK protein expression levels correlate with shorter survival in triple-negative breast cancer patientsThe small GTP-binding protein R-Ras can influence integrin activation by antagonizing a Ras/Raf-initiated integrin suppression pathwayThe Interconnections between Autophagy and Integrin-Mediated Cell Adhesion.Phosphorylation of phosphoprotein enriched in astrocytes (PEA-15) regulates extracellular signal-regulated kinase-dependent transcription and cell proliferation.Suppression of integrin activation by the membrane-distal sequence of the integrin alphaIIb cytoplasmic tail.Talin and signaling through integrins.Calcium/calmodulin-dependent protein kinase II regulation of c-FLIP expression and phosphorylation in modulation of Fas-mediated signaling in malignant glioma cells.
P2860
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P2860
The death effector domain of PEA-15 is involved in its regulation of integrin activation.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
The death effector domain of PEA-15 is involved in its regulation of integrin activation.
@en
The death effector domain of PEA-15 is involved in its regulation of integrin activation.
@nl
type
label
The death effector domain of PEA-15 is involved in its regulation of integrin activation.
@en
The death effector domain of PEA-15 is involved in its regulation of integrin activation.
@nl
prefLabel
The death effector domain of PEA-15 is involved in its regulation of integrin activation.
@en
The death effector domain of PEA-15 is involved in its regulation of integrin activation.
@nl
P2093
P2860
P356
P1476
The death effector domain of PEA-15 is involved in its regulation of integrin activation.
@en
P2093
C A Fenczik
M H Ginsberg
P E Hughes
T K Kojima
P2860
P304
33897-33900
P356
10.1074/JBC.273.51.33897
P407
P577
1998-12-01T00:00:00Z