Development of a potent inhibitor of 2-arachidonoylglycerol hydrolysis with antinociceptive activity in vivo.
about
Crystal structure of the human monoacylglycerol lipase, a key actor in endocannabinoid signalingThe serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptorsChemical probes of endocannabinoid metabolismMonoacylglycerol lipase - a target for drug development?Elevating endocannabinoid levels: pharmacological strategies and potential therapeutic applicationsFluorinated Cannabidiol Derivatives: Enhancement of Activity in Mice Models Predictive of Anxiolytic, Antidepressant and Antipsychotic Effects.Chemical approaches to therapeutically target the metabolism and signaling of the endocannabinoid 2-AG and eicosanoidsBiosynthesis and degradation of the endocannabinoid 2-arachidonoylglycerol.The endocannabinoid system and painEndocannabinoid tone versus constitutive activity of cannabinoid receptors.Human lung-resident macrophages express CB1 and CB2 receptors whose activation inhibits the release of angiogenic and lymphangiogenic factorsA novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol with potential anti-obesity effectsIdentification by nuclear magnetic resonance spectroscopy of an active-site hydrogen-bond network in human monoacylglycerol lipase (hMGL): implications for hMGL dynamics, pharmacological inhibition, and catalytic mechanism.Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signalingDynamic regulation of the endocannabinoid system: implications for analgesia.Dynamic changes to the endocannabinoid system in models of chronic pain.Prostamide F(2) α receptor antagonism combined with inhibition of FAAH may block the pro-inflammatory mediators formed following selective FAAH inhibitionPeripheral antinociceptive effects of inhibitors of monoacylglycerol lipase in a rat model of inflammatory pain.Monoglyceride lipase as a drug target: At the crossroads of arachidonic acid metabolism and endocannabinoid signaling.L-type calcium channels and MAP kinase contribute to thyrotropin-releasing hormone-induced depolarization in thalamic paraventricular nucleus neurons.Radiosynthesis and ex vivo evaluation of [(11)C-carbonyl]carbamate- and urea-based monoacylglycerol lipase inhibitors.Screening of various hormone-sensitive lipase inhibitors as endocannabinoid-hydrolyzing enzyme inhibitors.CB2 receptors regulate natural killer cells that limit allergic airway inflammation in a murine model of asthma.2-arachidonyl glycerol modulates astrocytic glutamine synthetase via p38 and ERK1/2 pathways
P2860
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P2860
Development of a potent inhibitor of 2-arachidonoylglycerol hydrolysis with antinociceptive activity in vivo.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh-hant
name
Development of a potent inhibi ...... inociceptive activity in vivo.
@en
Development of a potent inhibi ...... inociceptive activity in vivo.
@nl
type
label
Development of a potent inhibi ...... inociceptive activity in vivo.
@en
Development of a potent inhibi ...... inociceptive activity in vivo.
@nl
prefLabel
Development of a potent inhibi ...... inociceptive activity in vivo.
@en
Development of a potent inhibi ...... inociceptive activity in vivo.
@nl
P2093
P50
P1476
Development of a potent inhibi ...... inociceptive activity in vivo.
@en
P2093
Endocannabinoid Research Group
Enza Palazzo
Giorgio Ortar
Sabatino Maione
Stefania Petrosino
Tiziana Bisogno
P356
10.1016/J.BBALIP.2008.10.007
P577
2008-11-05T00:00:00Z