Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling
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The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptorsChemical probes of endocannabinoid metabolismTherapeutic potential of monoacylglycerol lipase inhibitorsMonoacylglycerol lipase - a target for drug development?Marijuana, Spice 'herbal high', and early neural development: implications for rescheduling and legalizationTherapeutic potential of inhibitors of endocannabinoid degradation for the treatment of stress-related hyperalgesia in an animal model of chronic painChronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system.The evolution and comparative neurobiology of endocannabinoid signallingEndocannabinoid-mediated synaptic plasticity and addiction-related behaviorS-SCAM, a rare copy number variation gene, induces schizophrenia-related endophenotypes in transgenic mouse model.Deficiency in endocannabinoid signaling in the nucleus accumbens induced by chronic unpredictable stress.Dual fatty acid amide hydrolase and monoacylglycerol lipase blockade produces THC-like Morris water maze deficits in mice.Endocannabinoid signaling in the etiology and treatment of major depressive illness.Monoacylglycerol lipase inhibition blocks chronic stress-induced depressive-like behaviors via activation of mTOR signaling.Endocannabinoid modulation of hyperaemia evoked by physiologically relevant stimuli in the rat primary somatosensory cortex.From Fertilisation to Implantation in Mammalian Pregnancy-Modulation of Early Human Reproduction by the Endocannabinoid System.Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases.Interactions of Cannabinoids With Biochemical SubstratesEndocannabinoids generated by Ca2+ or by metabotropic glutamate receptors appear to arise from different pools of diacylglycerol lipaseDistinct endocannabinoid control of GABA release at perisomatic and dendritic synapses in the hippocampus.Endocannabinoids in synaptic plasticity and neuroprotection.Endocannabinoid signalling: has it got rhythm?Chemical approaches to therapeutically target the metabolism and signaling of the endocannabinoid 2-AG and eicosanoidsEnhanced endocannabinoid-mediated modulation of rostromedial tegmental nucleus drive onto dopamine neurons in Sardinian alcohol-preferring ratsCytosolic phospholipase A2 alpha/arachidonic acid signaling mediates depolarization-induced suppression of excitation in the cerebellumLipolysis - a highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores.Endocannabinoid 2-arachidonoylglycerol protects neurons against β-amyloid insults.Cannabinoid receptor activation modifies NMDA receptor mediated release of intracellular calcium: implications for endocannabinoid control of hippocampal neural plasticityActivity-based protein profiling of organophosphorus and thiocarbamate pesticides reveals multiple serine hydrolase targets in mouse brainInhibition of monoacylglycerol lipase reduces nicotine withdrawalTarget-dependent control of synaptic inhibition by endocannabinoids in the thalamus.Inhibition of fatty acid amide hydrolase unmasks CB1 receptor and TRPV1 channel-mediated modulation of glutamatergic synaptic transmission in midbrain periaqueductal grey.BDNF interacts with endocannabinoids to regulate cocaine-induced synaptic plasticity in mouse midbrain dopamine neurons.Endocannabinoid tone versus constitutive activity of cannabinoid receptors.Inhibition of COX-2 expression by endocannabinoid 2-arachidonoylglycerol is mediated via PPAR-γ.Blockade of endocannabinoid hydrolytic enzymes attenuates precipitated opioid withdrawal symptoms in mice.The metabolic serine hydrolases and their functions in mammalian physiology and disease.Task-specific enhancement of hippocampus-dependent learning in mice deficient in monoacylglycerol lipase, the major hydrolyzing enzyme of the endocannabinoid 2-arachidonoylglycerolMetabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.Alterations of endocannabinoid signaling, synaptic plasticity, learning, and memory in monoacylglycerol lipase knock-out mice
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Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 07 August 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Blockade of 2-arachidonoylglyc ...... rade endocannabinoid signaling
@en
Blockade of 2-arachidonoylglyc ...... ade endocannabinoid signaling.
@nl
type
label
Blockade of 2-arachidonoylglyc ...... rade endocannabinoid signaling
@en
Blockade of 2-arachidonoylglyc ...... ade endocannabinoid signaling.
@nl
prefLabel
Blockade of 2-arachidonoylglyc ...... rade endocannabinoid signaling
@en
Blockade of 2-arachidonoylglyc ...... ade endocannabinoid signaling.
@nl
P2093
P2860
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P1476
Blockade of 2-arachidonoylglyc ...... rade endocannabinoid signaling
@en
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Cecilia J Hillard
Dalong Sun
Jonathan Z Long
Qing-song Liu
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P304
P356
10.1124/JPET.109.158162
P407
P577
2009-08-07T00:00:00Z