Preventive but not late amiloride therapy reduces morbidity and mortality of lung disease in betaENaC-overexpressing mice. - Wikidata - wikimedia - TriplyDB

Preventive but not late amiloride therapy reduces morbidity and mortality of lung disease in betaENaC-overexpressing mice.

Preventive but not late amiloride therapy reduces morbidity and mortality of lung disease in betaENaC-overexpressing mice.

http://www.wikidata.org/entity/Q46320247

about

Nedd4-2 and the regulation of epithelial sodium transport Airway surface liquid volume regulation determines different airway phenotypes in liddle compared with betaENaC-overexpressing mice Endotoxin inhalation alters lung development in neonatal mice Deletion of the ubiquitin ligase Nedd4L in lung epithelia causes cystic fibrosis-like disease Defining an inhibitory domain in the gamma subunit of the epithelial sodium channel Correlation of apical fluid-regulating channel proteins with lung function in human COPD lungs CFTR regulates early pathogenesis of chronic obstructive lung disease in βENaC-overexpressing mice Lack of neutrophil elastase reduces inflammation, mucus hypersecretion, and emphysema, but not mucus obstruction, in mice with cystic fibrosis-like lung disease.Linking increased airway hydration, ciliary beating, and mucociliary clearance through ENaC inhibition Novel small molecule epithelial sodium channel inhibitors as potential therapeutics in cystic fibrosis - a patent evaluation.Measurement of the airway surface liquid volume with simple light refraction microscopy.Hypoxic epithelial necrosis triggers neutrophilic inflammation via IL-1 receptor signaling in cystic fibrosis lung disease.Antiinflammatory and Antimicrobial Effects of Thiocyanate in a Cystic Fibrosis Mouse Model.CFTR, mucins, and mucus obstruction in cystic fibrosis.Hypertonic saline is effective in the prevention and treatment of mucus obstruction, but not airway inflammation, in mice with chronic obstructive lung disease UDP-glucose promotes neutrophil recruitment in the lung.Pharmacological and genetic reappraisals of protease and oxidative stress pathways in a mouse model of obstructive lung diseases.Regulation of the epithelial Na+ channel and airway surface liquid volume by serine proteases.Regulation of airway mucosal hydration.SPX-101 is a Novel ENaC-targeted Therapeutic for Cystic Fibrosis that Restores Mucus Transport.The function and regulation of acid-sensing ion channels (ASICs) and the epithelial Na(+) channel (ENaC): IUPHAR Review 19.Early detection and sensitive monitoring of CF lung disease: Prospects of improved and safer imaging.Airway mucus, inflammation and remodeling: emerging links in the pathogenesis of chronic lung diseases.Inhibition of Protease-Epithelial Sodium Channel Signaling Improves Mucociliary Function in Cystic Fibrosis Airways.NVP-QBE170: an inhaled blocker of the epithelial sodium channel with a reduced potential to induce hyperkalaemia.Use of a new-generation reverse tetracycline transactivator system for quantitative control of conditional gene expression in the murine lung.δβγ-ENaC is inhibited by CFTR but stimulated by cAMP in Xenopus laevis oocytes.A mutation of the epithelial sodium channel associated with atypical cystic fibrosis increases channel open probability and reduces Na+ self inhibition.Update in cystic fibrosis 2008.Role of the amiloride-sensitive epithelial Na+ channel in the pathogenesis and as a therapeutic target for cystic fibrosis lung disease.Amiloride: still a viable treatment option in cystic fibrosis?Evaluation of a SPLUNC1-derived peptide for the treatment of cystic fibrosis lung disease.A Protease Inhibitor Tackles Epithelial Sodium Channels in Cystic Fibrosis.A mutation in the β-subunit of ENaC identified in a patient with cystic fibrosis-like symptoms has a gain-of-function effect.Therapeutic attenuation of the epithelial sodium channel with a SPLUNC1-derived peptide in airway diseases.Magnetic Resonance Imaging Detects Changes in Structure and Perfusion, and Response to Therapy in Early Cystic Fibrosis Lung Disease Recent advances in developing therapeutics for cystic fibrosis

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P2860

Preventive but not late amiloride therapy reduces morbidity and mortality of lung disease in betaENaC-overexpressing mice.

http://www.wikidata.org/entity/Q46320247

description

2008 nî lūn-bûn

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2008年の論文

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年學術文章

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2008年學術文章

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name

Preventive but not late amilor ...... betaENaC-overexpressing mice.

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Preventive but not late amilor ...... betaENaC-overexpressing mice.

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Preventive but not late amilor ...... betaENaC-overexpressing mice.

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Preventive but not late amilor ...... betaENaC-overexpressing mice.

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Preventive but not late amilor ...... betaENaC-overexpressing mice.

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American Journal of Respiratory and Critical Care Medicine

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Preventive but not late amilor ...... n betaENaC-overexpressing mice

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P2093

Diana Treis

http://www.w3.org/2001/XMLSchema#string

Jolanthe Schatterny

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Marcus A Mall

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Maria Harm

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Richard C Boucher

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Stephanie Hirtz

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Susanne C Schubert

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Zhe Zhou

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P2860

Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease

Fenretinide corrects newly found ceramide deficiency in cystic fibrosis

Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits

Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice

CYSTIC FIBROSIS OF THE PANCREAS AND ITS RELATION TO CELIAC DISEASE

Identification of the cystic fibrosis gene: genetic analysis

Na+ transport in cystic fibrosis respiratory epithelia. Abnormal basal rate and response to adenylate cyclase activation.

Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening.

Effect of aerosolized recombinant human DNase on exacerbations of respiratory symptoms and on pulmonary function in patients with cystic fibrosis. The Pulmozyme Study Group.

Evaluation of second generation amiloride analogs as therapy for cystic fibrosis lung disease.

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18849497

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