Spinal cord injury-induced attenuation of GABAergic inhibition in spinal dorsal horn circuits is associated with down-regulation of the chloride transporter KCC2 in rat.
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NMDA receptor activity downregulates KCC2 resulting in depolarizing GABAA receptor-mediated currentsSerotonergic modulation of post-synaptic inhibition and locomotor alternating pattern in the spinal cordAcrolein involvement in sensory and behavioral hypersensitivity following spinal cord injury in the ratChemogenetic silencing of GABAergic dorsal horn interneurons induces morphine-resistant spontaneous nocifensive behaviours.Anomalous expression of chloride transporters in the sclerosed hippocampus of mesial temporal lobe epilepsy patientsChloride extrusion enhancers as novel therapeutics for neurological diseasesImmature spinal cord neurons are dynamic regulators of adult nociceptive sensitivity.The animal model of spinal cord injury as an experimental pain model.A feed-forward spinal cord glycinergic neural circuit gates mechanical allodyniaActivation of 5-HT2A receptors upregulates the function of the neuronal K-Cl cotransporter KCC2.Disrupted Cl(-) homeostasis contributes to reductions in the inhibitory efficacy of diazepam during hyperexcited statesBilateral transient changes in thalamic nucleus ventroposterior lateralis after thoracic hemisection in the ratDifferential effects on KCC2 expression and spasticity of ALS and traumatic injuries to motoneurons.Altered rate-dependent depression of the spinal H-reflex as an indicator of spinal disinhibition in models of neuropathic painGABA and central neuropathic pain following spinal cord injurySpatial and temporal dynamics in the ionic driving force for GABA(A) receptors.GABAergic synchronization in the limbic system and its role in the generation of epileptiform activity.Cortical inhibition, pH and cell excitability in epilepsy: what are optimal targets for antiepileptic interventions?How do short-term changes at synapses fine-tune information processing?Reappraising neuropathic pain in humans--how symptoms help disclose mechanisms.Microglia control neuronal network excitability via BDNF signalling.GABA pharmacology: the search for analgesics.Emerging role of WNK1 in pathologic central nervous system signaling.Neuroplasticity of ascending and descending pathways after somatosensory system injury: reviewing knowledge to identify neuropathic pain therapeutic targets.Neuropathic pain following traumatic spinal cord injury: Models, measurement, and mechanisms.Rehabilitation Strategies after Spinal Cord Injury: Inquiry into the Mechanisms of Success and Failure.A Comparison of the α2/3/5 Selective Positive Allosteric Modulators L-838,417 and TPA023 in Preclinical Models of Inflammatory and Neuropathic Pain.Chronic Unpredictable Mild Stress Induces Loss of GABA Inhibition in Corticotrophin-Releasing Hormone-Expressing Neurons through NKCC1 Upregulation.Opposite, bidirectional shifts in excitation and inhibition in specific types of dorsal horn interneurons are associated with spasticity and pain post-SCI.Nociceptors as chronic drivers of pain and hyperreflexia after spinal cord injury: an adaptive-maladaptive hyperfunctional state hypothesis.Spasticity: a switch from inhibition to excitation.Adult spinal cord neurogenesis: A regulator of nociception.Decoding the language of epigenetics during neural development is key for understanding development as well as developmental neurotoxicity.Retracing your footsteps: developmental insights to spinal network plasticity following injury.Progressive limb ataxia following inferior olive lesions.BDNF Induced by Treadmill Training Contributes to the Suppression of Spasticity and Allodynia After Spinal Cord Injury via Upregulation of KCC2.When Pain Hurts: Nociceptive Stimulation Induces a State of Maladaptive Plasticity and Impairs Recovery after Spinal Cord Injury.Acute spinal cord injury (SCI) transforms how GABA affects nociceptive sensitization.Acute inhibition of signalling phenotype of spinal GABAergic neurons by tumour necrosis factor-alpha.Neuropathic pain after chronic nerve constriction may not correlate with chloride dysregulation in mouse trigeminal nucleus caudalis neurons.
P2860
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P2860
Spinal cord injury-induced attenuation of GABAergic inhibition in spinal dorsal horn circuits is associated with down-regulation of the chloride transporter KCC2 in rat.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Spinal cord injury-induced att ...... oride transporter KCC2 in rat.
@en
Spinal cord injury-induced att ...... oride transporter KCC2 in rat.
@nl
type
label
Spinal cord injury-induced att ...... oride transporter KCC2 in rat.
@en
Spinal cord injury-induced att ...... oride transporter KCC2 in rat.
@nl
prefLabel
Spinal cord injury-induced att ...... oride transporter KCC2 in rat.
@en
Spinal cord injury-induced att ...... oride transporter KCC2 in rat.
@nl
P2093
P2860
P1476
Spinal cord injury-induced att ...... oride transporter KCC2 in rat.
@en
P2093
Jihong Zheng
Lize Xiong
Manfred Zimmermann
P2860
P304
P356
10.1113/JPHYSIOL.2008.152348
P407
P577
2008-10-09T00:00:00Z