Rho/ROCK and MEK/ERK activation by transforming growth factor-alpha induces articular cartilage degradation.
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The role of changes in extracellular matrix of cartilage in the presence of inflammation on the pathology of osteoarthritisDeletion of Dual Specificity Phosphatase 1 Does Not Predispose Mice to Increased Spontaneous OsteoarthritisLow intensity pulsed ultrasound (LIPUS) influences the multilineage differentiation of mesenchymal stem and progenitor cell lines through ROCK-Cot/Tpl2-MEK-ERK signaling pathwayProteomic changes in articular cartilage of human endemic osteoarthritis in China.Accelerated and increased joint damage in young mice with global inactivation of mitogen-inducible gene 6 after ligament and meniscus injury.Strategies to minimize hypertrophy in cartilage engineering and regeneration.MEK-ERK pathway modulation ameliorates pulmonary fibrosis associated with epidermal growth factor receptor activationChondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis.PAQR3: a novel tumor suppressor gene.Rac1 is required for matrix metalloproteinase 13 production by chondrocytes in response to fibronectin fragmentsContext-specific protection of TGFα null mice from osteoarthritis.Cartilage-specific deletion of Mig-6 results in osteoarthritis-like disorder with excessive articular chondrocyte proliferation.Pro-inflammatory stimulation of meniscus cells increases production of matrix metalloproteinases and additional catabolic factors involved in osteoarthritis pathogenesis.Wnt and Rho GTPase signaling in osteoarthritis development and intervention: implications for diagnosis and therapy.Disturbed cartilage and joint homeostasis resulting from a loss of mitogen-inducible gene 6 in a mouse model of joint dysfunction.Biology and pathology of Rho GTPase, PI-3 kinase-Akt, and MAP kinase signaling pathways in chondrocytes.Novel Insights into Osteoarthritis Joint Pathology from Studies in Mice.Chemokines and inflammation in osteoarthritis: Insights from patients and animal models.Platelet-derived growth factor-BB induces matrix metalloproteinase-2 expression and rat vascular smooth muscle cell migration via ROCK and ERK/p38 MAPK pathways.Nuclear receptors regulate lipid metabolism and oxidative stress markers in chondrocytes.ROCK inhibition enhances aggrecan deposition and suppresses matrix metalloproteinase-3 production in human articular chondrocytes.Subcellular domain-dependent molecular hierarchy of SFK and FAK in mechanotransduction and cytokine signalingFluvastatin upregulates the α 1C subunit of CaV1.2 channel expression in vascular smooth muscle cells via RhoA and ERK/p38 MAPK pathwaysHeparin-binding epidermal growth factor-like growth factor (HB-EGF) is increased in osteoarthritis and regulates chondrocyte catabolic and anabolic activitiesERK activation is required for hydrostatic pressure-induced tensile changes in engineered articular cartilage.Slit2 modifies VEGF-induced angiogenic responses in rabbit skeletal muscle via reduced eNOS activity.Peroxisome proliferator-activated receptor δ promotes the progression of posttraumatic osteoarthritis in a mouse model.Electroacupuncture serum inhibits TNF‑α‑mediated chondrocyte inflammation via the Ras‑Raf‑MEK1/2‑ERK1/2 signaling pathway.Reduction in disease progression by inhibition of transforming growth factor α-CCL2 signaling in experimental posttraumatic osteoarthritis.Intra-articular Injection of platelet-rich fibrin releasates in combination with bone marrow-derived mesenchymal stem cells in the treatment of articular cartilage defects: An in vivo study in rabbits.Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis.Glucosamine promotes chondrocyte proliferation via the Wnt/β‑catenin signaling pathway.Regulation of chondrocyte proliferation through GIT1-Rac1-mediated ERK1/2 pathway by PDGF.Combination of MEK-ERK inhibitor and hyaluronic acid has a synergistic effect on anti-hypertrophic and pro-chondrogenic activities in osteoarthritis treatment.Transforming growth factor-α attenuates hepatic fibrosis: possible involvement of matrix metalloproteinase-1.Gefitinib for Epidermal Growth Factor Receptor Activated Osteoarthritis Subpopulation Treatment.
P2860
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P2860
Rho/ROCK and MEK/ERK activation by transforming growth factor-alpha induces articular cartilage degradation.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh-hant
name
Rho/ROCK and MEK/ERK activatio ...... ticular cartilage degradation.
@en
Rho/ROCK and MEK/ERK activatio ...... ticular cartilage degradation.
@nl
type
label
Rho/ROCK and MEK/ERK activatio ...... ticular cartilage degradation.
@en
Rho/ROCK and MEK/ERK activatio ...... ticular cartilage degradation.
@nl
prefLabel
Rho/ROCK and MEK/ERK activatio ...... ticular cartilage degradation.
@en
Rho/ROCK and MEK/ERK activatio ...... ticular cartilage degradation.
@nl
P2860
P1476
Rho/ROCK and MEK/ERK activatio ...... ticular cartilage degradation.
@en
P2093
John S Mort
Shirine E Usmani
P2860
P2888
P356
10.1038/LABINVEST.2009.111
P577
2009-10-12T00:00:00Z