TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage
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Mechanisms for asporin function and regulation in articular cartilageSmad3 prevents beta-catenin degradation and facilitates beta-catenin nuclear translocation in chondrocytesA functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc diseaseSMAD3 deficiency promotes inflammatory aortic aneurysms in angiotensin II-infused mice via activation of iNOSAdult mesenchymal stem cells and cell-based tissue engineeringBMP receptor signaling is required for postnatal maintenance of articular cartilageThe SmadsTGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and diseaseWnts talking with the TGF-β superfamily: WISPers about modulation of osteoarthritisAdvances in understanding cartilage remodelingThe Regulatory Role of Signaling Crosstalk in Hypertrophy of MSCs and Human Articular ChondrocytesInterplay between cartilage and subchondral bone contributing to pathogenesis of osteoarthritisOsteoarthritis pathogenesis: a review of molecular mechanismsDoxorubicin-mediated bone loss in breast cancer bone metastases is driven by an interplay between oxidative stress and induction of TGFβ24R,25-Dihydroxyvitamin D3 Protects against Articular Cartilage Damage following Anterior Cruciate Ligament Transection in Male RatsInteraction of TGFβ and BMP signaling pathways during chondrogenesisBone morphogenetic proteins 2 and 6, expressed in arthritic synovium, are regulated by proinflammatory cytokines and differentially modulate fibroblast-like synoviocyte apoptosisFollistatin-like protein 1 regulates chondrocyte proliferation and chondrogenic differentiation of mesenchymal stem cellsExpression and regulation of the osteoarthritis-associated protein asporinAn aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritisLung alveolar septation defects in Ltbp-3-null miceDevelopmentally regulated expression of mouse HtrA3 and its role as an inhibitor of TGF-beta signalingFunctional knockout of the matrilin-3 gene causes premature chondrocyte maturation to hypertrophy and increases bone mineral density and osteoarthritisAxin2 regulates chondrocyte maturation and axial skeletal developmentBone abnormalities in latent TGF-[beta] binding protein (Ltbp)-3-null mice indicate a role for Ltbp-3 in modulating TGF-[beta] bioavailabilityAnti-transforming growth factor ß antibody treatment rescues bone loss and prevents breast cancer metastasis to bonePharmacologic inhibition of the TGF-beta type I receptor kinase has anabolic and anti-catabolic effects on bone.SnoN suppresses maturation of chondrocytes by mediating signal cross-talk between transforming growth factor-β and bone morphogenetic protein pathways.Filamin B represses chondrocyte hypertrophy in a Runx2/Smad3-dependent manner.Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritisInhibition of ALK5 signaling induces physeal dysplasia in rats.Identification of unique molecular subdomains in the perichondrium and periosteum and their role in regulating gene expression in the underlying chondrocytesMolecular profiling of the developing mouse axial skeleton: a role for Tgfbr2 in the development of the intervertebral disc.AIMP1 downregulation restores chondrogenic characteristics of dedifferentiated/degenerated chondrocytes by enhancing TGF-β signal.Biglycan and fibromodulin have essential roles in regulating chondrogenesis and extracellular matrix turnover in temporomandibular joint osteoarthritis.Integrin α1β1 differentially regulates cytokine-mediated responses in chondrocytes.SMAD3 is associated with the total burden of radiographic osteoarthritis: the Chingford study.Smad signaling in skeletal development and regeneration.Conditional removal of the canonical TGF-β1 signaling delays condylar cartilage degeneration induced by a partial discectomy in miceMicroRNA-146a regulates human foetal femur derived skeletal stem cell differentiation by down-regulating SMAD2 and SMAD3.
P2860
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P2860
TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
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2001年學術文章
@zh-hant
name
TGF-beta/Smad3 signals repress ...... aintaining articular cartilage
@ast
TGF-beta/Smad3 signals repress ...... aintaining articular cartilage
@en
type
label
TGF-beta/Smad3 signals repress ...... aintaining articular cartilage
@ast
TGF-beta/Smad3 signals repress ...... aintaining articular cartilage
@en
prefLabel
TGF-beta/Smad3 signals repress ...... aintaining articular cartilage
@ast
TGF-beta/Smad3 signals repress ...... aintaining articular cartilage
@en
P2093
P2860
P356
P1476
TGF-beta/Smad3 signals repress ...... aintaining articular cartilage
@en
P2093
P2860
P356
10.1083/JCB.153.1.35
P407
P50
P577
2001-04-01T00:00:00Z