Reduced expression of the Sp4 gene in mice causes deficits in sensorimotor gating and memory associated with hippocampal vacuolization.
about
Restoration of Sp4 in Forebrain GABAergic Neurons Rescues Hypersensitivity to Ketamine in Sp4 Hypomorphic Mice.Glutamate receptor activation evokes calpain-mediated degradation of Sp3 and Sp4, the prominent Sp-family transcription factors in neuronsNovel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studiesGenome-wide association study of recurrent early-onset major depressive disorderProlonged Ketamine Effects in Sp4 Hypomorphic Mice: Mimicking Phenotypes of Schizophrenia.Genetic models of sensorimotor gating: relevance to neuropsychiatric disorders.Prepulse inhibition and genetic mouse models of schizophrenia.Transcription factor SP4 is a susceptibility gene for bipolar disorderReduced NMDAR1 expression in the Sp4 hypomorphic mouse may contribute to endophenotypes of human psychiatric disordersStore-operated calcium entry promotes the degradation of the transcription factor Sp4 in resting neurons.GlyT-1 Inhibition Attenuates Attentional But Not Learning or Motivational Deficits of the Sp4 Hypomorphic Mouse Model Relevant to Psychiatric DisordersConservation and regulatory associations of a wide affinity range of mouse transcription factor binding sitesRegulation of Na(+)/K(+)-ATPase by neuron-specific transcription factor Sp4: implication in the tight coupling of energy production, neuronal activity and energy consumption in neurons.Specificity protein 4 (Sp4) regulates the transcription of AMPA receptor subunit GluA2 (Gria2)The genetics of major depression: moving beyond the monoamine hypothesis.Transcription factor Sp4 regulates expression of nervous wreck 2 to control NMDAR1 levels and dendrite patterning.Transcription factors Sp1 and Sp4 regulate TRPV1 gene expression in rat sensory neurons.The transcription factor SP4 is reduced in postmortem cerebellum of bipolar disorder subjects: control by depolarization and lithium.Stim and Orai proteins in neuronal Ca(2+) signaling and excitabilityPhosphorylation of transcription factor specificity protein 4 is increased in peripheral blood mononuclear cells of first-episode psychosisTranscription factor Sp4 regulates dendritic patterning during cerebellar maturationThe role of protein intrinsic disorder in major psychiatric disorders.Differential transcriptional control of the superoxide dismutase-2 kappaB element in neurons and astrocytesTranscription factor SP4 phosphorylation is altered in the postmortem cerebellum of bipolar disorder and schizophrenia subjectsSp4-dependent repression of neurotrophin-3 limits dendritic branching.Specificity protein 4 functionally regulates the transcription of NMDA receptor subunits GluN1, GluN2A, and GluN2B.Phosphorylation of the transcription factor Sp4 is reduced by NMDA receptor signaling.Mechanisms regulating dendritic arbor patterning.FUS/TLS deficiency causes behavioral and pathological abnormalities distinct from amyotrophic lateral sclerosis.Cellular transcription factors Sp1 and Sp3 suppress varicella-zoster virus origin-dependent DNA replication.Class I histone deacetylase-mediated repression of the proximal promoter of the activity-regulated cytoskeleton-associated protein gene regulates its response to brain-derived neurotrophic factor.Escalating dose-multiple binge methamphetamine exposure results in degeneration of the neocortex and limbic system in the rat.Genome-wide localization and expression profiling establish Sp2 as a sequence-specific transcription factor regulating vitally important genes.Specificity protein 4 (Sp4) transcriptionally regulates inhibitory GABAergic receptors in neurons.Impaired postnatal development of hippocampal dentate gyrus in Sp4 null mutant mice.Deficiency of aminopeptidase P1 causes behavioral hyperactivity, cognitive deficits, and hippocampal neurodegeneration.Regulation of neurotrophin-3 gene transcription by Sp3 and Sp4 in neurons.Genetics of psychotropic medication induced side effects in two independent samples of bipolar patients.Sp2 is the only glutamine-rich specificity protein with minor impact on development and differentiation in myelinating glia.Ketamine independently modulated power and phase-coupling of theta oscillations in Sp4 hypomorphic mice.
P2860
Q27300750-AC336ED2-86B0-49CA-B217-6748D643C696Q28289604-F8B60748-4704-45F4-896E-319A45FD7BEBQ28751388-D1F9DE6C-4B3B-4BD6-A7EF-647DB7C40E66Q28943558-BD7303C7-18B3-493A-8812-4B0ED4DB09FDQ30452766-57331CE4-6B8D-488E-8FD4-C69A65A38198Q30459497-F97A794F-027E-4385-A7C1-A7E8A9237DA2Q30478270-F5916C9F-D1EB-47C1-84D4-DE1DEEA2C977Q30490052-22674689-A0AF-4345-A26C-CBC49E772B07Q30496492-664B72B9-69C1-4B6F-92FF-B4CA0F8EB777Q30651908-972F43F1-DB6B-499B-AA6F-AC562EF71A5DQ30756194-68E3E322-2879-4BEE-AE41-6304B155E3EDQ33524650-2BB28A4F-CC92-4B40-A04B-CD781EBC1113Q33598310-A2D7CC3F-F9DA-4438-A679-713B6343DE7AQ33624561-0AD62A43-15D3-45C8-8CA7-9E8E42975F6EQ33669125-FD74F5AB-2E1F-4C18-8C9D-5DE26C84011EQ34664094-080F535C-06F6-4E9E-B587-517A576FB093Q35063692-74F33FEB-7FC8-46FB-A2BB-B1CDDE1F7D66Q35451948-A147AA11-5989-4ABA-A395-A4F99290E034Q35535117-2BD23903-6198-452B-836B-36CE81435800Q35542618-3E683BCD-791A-42AE-8E02-3661F0EB8382Q35834381-0D7CE876-754D-4489-A1B9-88D8A3246BA7Q36019033-931068E3-982B-4356-80B7-3C1F08005C36Q36116583-584C883F-5E30-4E1B-A748-F57420DEA222Q36145508-533CBFD8-C8EA-4B07-8655-35BA02AC8C08Q37307938-330FF628-8D12-4CAA-8F3F-45B72F0D86BBQ37325823-F57A1270-F028-4D97-9594-024FBA6B4051Q38959725-6D81B270-E02A-4076-AFA3-213641F1F8CFQ39452587-E2CF6D27-7EC5-466C-BAC3-5CE8A27141D9Q39927199-60519BC4-19DC-4E14-A844-9CBE5105CB77Q39936103-1060283B-1C37-4799-9918-EC2868BFBD0CQ41523839-CF888665-2EC9-4651-A36A-93BE20E6C368Q42253970-0F50AFF8-B69B-43C8-9DE6-1B9E0BA7BB0DQ42324809-69B275A4-2DF2-4832-8A91-9CE94577F5E3Q43157530-86B1EA0D-4B8A-495F-83A5-ACB7CA456A64Q46150035-6D9CCED6-A691-434D-83CD-9CCD731485ABQ47917105-D52AFCCE-7274-49EA-BD1C-DD96FFA62193Q48389571-7976EEA4-F9A9-4856-9BC3-643E737D1CB1Q48600739-1BFDFDB8-12C1-412D-8E39-1D6D8191C311Q50473907-F7BEC66C-B939-4EA5-A50E-BE99C78A1451Q55005412-3274ED38-9EEB-421C-AF59-A485D2265058
P2860
Reduced expression of the Sp4 gene in mice causes deficits in sensorimotor gating and memory associated with hippocampal vacuolization.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Reduced expression of the Sp4 ...... ith hippocampal vacuolization.
@en
Reduced expression of the Sp4 ...... ith hippocampal vacuolization.
@nl
type
label
Reduced expression of the Sp4 ...... ith hippocampal vacuolization.
@en
Reduced expression of the Sp4 ...... ith hippocampal vacuolization.
@nl
prefLabel
Reduced expression of the Sp4 ...... ith hippocampal vacuolization.
@en
Reduced expression of the Sp4 ...... ith hippocampal vacuolization.
@nl
P2093
P2860
P356
P1433
P1476
Reduced expression of the Sp4 ...... ith hippocampal vacuolization.
@en
P2093
Wynshaw-Boris A
P2860
P2888
P304
P356
10.1038/SJ.MP.4001621
P407
P577
2005-04-01T00:00:00Z