Tpl2 (tumor progression locus 2) phosphorylation at Thr290 is induced by lipopolysaccharide via an Ikappa-B Kinase-beta-dependent pathway and is required for Tpl2 activation by external signals. - Wikidata - wikimedia - TriplyDB

Tpl2 (tumor progression locus 2) phosphorylation at Thr290 is induced by lipopolysaccharide via an Ikappa-B Kinase-beta-dependent pathway and is required for Tpl2 activation by external signals.

Tpl2 (tumor progression locus 2) phosphorylation at Thr290 is induced by lipopolysaccharide via an Ikappa-B Kinase-beta-dependent pathway and is required for Tpl2 activation by external signals.

http://www.wikidata.org/entity/Q46390923

about

The tyrosine kinase Syk regulates TPL2 activation signals Pancreatic adenocarcinoma upregulated factor promotes metastasis by regulating TLR/CXCR4 activation The selectivity of protein kinase inhibitors: a further update Tumor progression locus 2 (Tpl2) kinase as a novel therapeutic target for cancer: double-sided effects of Tpl2 on cancer Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase Transcriptional networks in plasmacytoid dendritic cells stimulated with synthetic TLR 7 agonists Tumor progression locus 2 (TPL2) regulates obesity-associated inflammation and insulin resistance.TPL-2 Regulates Macrophage Lipid Metabolism and M2 Differentiation to Control TH2-Mediated Immunopathology.Phosphorylation of TPL-2 on serine 400 is essential for lipopolysaccharide activation of extracellular signal-regulated kinase in macrophages.IκB kinase 2 regulates TPL-2 activation of extracellular signal-regulated kinases 1 and 2 by direct phosphorylation of TPL-2 serine 400 A comprehensive map of the toll-like receptor signaling network.Role of mitogen-activated protein kinase kinase kinases in signal integration.Tpl2 inhibitors thwart endothelial cell function in angiogenesis and peritoneal dissemination.IκB kinase regulation of the TPL-2/ERK MAPK pathway.IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2.Deregulated activation of oncoprotein kinase Tpl2/Cot in HTLV-I-transformed T cells.Myeloid-specific GPCR kinase-2 negatively regulates NF-κB1p105-ERK pathway and limits endotoxemic shock in mice Tumor progression locus 2-dependent oxidative burst drives phosphorylation of extracellular signal-regulated kinase during TLR3 and 9 signaling.The interplay between cyclic AMP, MAPK, and NF-κB pathways in response to proinflammatory signals in microglia.A TPL2 (MAP3K8) disease-risk polymorphism increases TPL2 expression thereby leading to increased pattern recognition receptor-initiated caspase-1 and caspase-8 activation, signalling and cytokine secretion.MAP3K8 is phosphorylated Interleukin-1 stimulated activation of the COT catalytic subunit through the phosphorylation of Thr290 and Ser62.Involvement of Cot/Tp12 in bone loss during periodontitis.

P2860

Q24295249-0BE3EB56-C379-4D90-97EC-5F2121377B68 Q24298015-7F21C57D-8DFC-4229-B422-5A28364BDBD1 Q24654622-E8E561B8-F908-4C52-81EF-594634A00E74 Q27021391-4ADFAE6D-8290-4D2B-9B1F-8FA2156ECC57 Q28392677-732627B8-3D60-4CA5-B7EB-95B6CD9E9670 Q33302568-78FD0E14-F391-4B29-9B92-DDCCAB5D2F48 Q34718730-2052B933-4F76-4C2F-8342-E31C3B33F256 Q36093909-D3519A94-E504-47EB-9113-3BC96DB6AA0D Q36315622-2C7C0B5C-DE41-4D1A-B0B5-D4480D21CF1F Q36362907-B987E56A-351A-4065-BFBF-70FB89E77432 Q36494115-E649AA58-8A4D-49E7-93E5-0C1FC205673D Q36819381-1681A6A4-89E0-48DC-871B-8908731F29EA Q37162383-B70E9F74-DF2F-4B69-8A4C-03E049780669 Q37995683-268DF1A4-A530-46DE-8F79-ACAB73879064 Q39799629-5EA245DE-E506-4285-A2A0-27F88EB38227 Q40299856-2E9C6774-B6DB-4035-A069-70A16362A198 Q41565044-A7D54A0C-3086-49F6-AE9C-4F59208C8907 Q41672710-78A528B0-06FE-4BDD-BD27-EF6640E47138 Q42241217-DAA4EF99-9DC1-445F-BE21-5057C1DAE842 Q42741761-3176AE4B-E7E3-4BB8-8541-BD9CA859A899 Q50291706-A567F715-F37A-4905-8B58-852BA1931300 Q50335837-9D30B6FD-CA16-406F-B39F-0B9F201134E6 Q51917295-A8572300-6E5D-4814-A973-3308B9C50F2F

P2860

Tpl2 (tumor progression locus 2) phosphorylation at Thr290 is induced by lipopolysaccharide via an Ikappa-B Kinase-beta-dependent pathway and is required for Tpl2 activation by external signals.

http://www.wikidata.org/entity/Q46390923

description

2005 nî lūn-bûn

@nan

2005年の論文

@ja

2005年学术文章

@wuu

2005年学术文章

@zh-cn

2005年学术文章

@zh-hans

2005年学术文章

@zh-my

2005年学术文章

@zh-sg

2005年學術文章

@yue

2005年學術文章

@zh

2005年學術文章

@zh-hant

name

Tpl2 (tumor progression locus ...... ctivation by external signals.

@en

Tpl2

@nl

type

label

Tpl2 (tumor progression locus ...... ctivation by external signals.

@en

Tpl2

@nl

prefLabel

Tpl2 (tumor progression locus ...... ctivation by external signals.

@en

Tpl2

@nl

P1433

Q46390923-58B98949-406F-4AC9-9455-1EB1BB19FC36

P1476

Q46390923-E1F7FB4C-4154-4BFD-923B-15C1B71A5DEB

P2093

Q46390923-601CF0C7-4203-4C3C-9C00-68D396ACA044

Q46390923-6F3F3675-38E4-42D6-A949-8016EFF4C9D7

Q46390923-B9E1CA87-72BD-4E3E-8389-1A16B1E5A0B1

Q46390923-ED064D06-A6E5-41AA-9801-DAB6A231B87D

P2860

Q46390923-18CF7E34-04BF-4861-B7E0-0C8EB9D78EBF

Q46390923-1D2F89B5-0C49-47E1-852C-02B3514FF413

Q46390923-2403A4EC-A277-40F7-B141-C38FA7ED6C8B

Q46390923-32C4DE83-86C7-4623-850A-ECB7D29CB399

Q46390923-5046AEF7-6A50-482B-8771-C06ABB1BC0A3

Q46390923-607FDC49-4AF5-4042-B015-72CD37937AE6

Q46390923-69BA5B0F-6FB1-4D25-88C3-34F5E42B7B35

Q46390923-757CFDE7-B7CD-4F24-A3E1-A91C6202DFB1

Q46390923-7CEC1727-4EA1-41C1-9E0F-2EDA05F16A72

Q46390923-81125E25-87D8-4F00-ADA9-4434FDC47DA7

P304

Q46390923-4C955B91-9749-4795-8E7B-3492B47C50C1

P31

Q46390923-3F16FEDE-9315-4AC0-B0C1-2F98D24F2F6B

P356

Q46390923-9544332C-496A-425F-AE73-51302F05B644

P407

Q46390923-05AB6F2B-C752-468E-B49D-8A9A00D223CF

P433

Q46390923-62284C70-5080-4CD0-8CFA-591DD477E627

P478

Q46390923-2D587A1B-87BA-4F97-9EBC-250FD1D99DC0

P577

Q46390923-E5955D5B-6334-4474-9FB9-F094535BAF90

P698

Q46390923-A034874D-02A9-4E40-9E4A-59CAAEFEBFA2

P921

Q46390923-1D07F886-92ED-43C4-8A2E-CBFEA68B257D

Q46390923-92FA6729-A598-4946-8450-90C634B6CFB9

P356

P1433

Journal of Biological Chemistry

P1476

Tpl2 (tumor progression locus ...... ctivation by external signals.

@en

P2093

Georgios P Solidakis

http://www.w3.org/2001/XMLSchema#string

Jeonghee Cho

http://www.w3.org/2001/XMLSchema#string

Michael Melnick

http://www.w3.org/2001/XMLSchema#string

Philip N Tsichlis

http://www.w3.org/2001/XMLSchema#string

P2860

Cross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the lck tyrosine protein kinase at the autophosphorylation site

NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes

Multiple mitogen-activated protein kinase signaling pathways connect the cot oncoprotein to the c-jun promoter and to cellular transformation

The COOH-terminal domain of wild-type Cot regulates its stability and kinase specific activity

The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases

NF-kappaB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase

TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105

Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease.

TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway.

P304

20442-20448

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1074/JBC.M413554200

http://www.w3.org/2001/XMLSchema#string

P407

P433

21

http://www.w3.org/2001/XMLSchema#string

P478

280

http://www.w3.org/2001/XMLSchema#string

P577

2005-03-18T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

15778223

http://www.w3.org/2001/XMLSchema#string

P921

phosphorylation

lipopolysaccharide