Lower induction of p53 and decreased apoptosis in NQO1-null mice lead to increased sensitivity to chemical-induced skin carcinogenesis.
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In Silico Screening Reveals Structurally Diverse, Nanomolar Inhibitors of NQO2 That Are Functionally Active in Cells and Can Modulate NF- B SignalingNAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotectorGene expression signature analysis identifies vorinostat as a candidate therapy for gastric cancerGlobal gene expression profiling of endothelium exposed to heme reveals an organ-specific induction of cytoprotective enzymes in sickle cell disease.NAD(P)H:quinone oxidoreductase 1 is induced by progesterone in cardiomyocytes.Inactivation of the quinone oxidoreductases NQO1 and NQO2 strongly elevates the incidence and multiplicity of chemically induced skin tumors.Topical application of ochratoxin A causes DNA damage and tumor initiation in mouse skin.NQO1-induced activation of AMPK contributes to cancer cell death by oxygen-glucose deprivation.Genetic evidence for NAD(P)H:quinone oxidoreductase 1-catalyzed quinone reduction on passage through the mouse pulmonary circulation.NRH:quinone oxidoreductase 2-deficient mice are highly susceptible to radiation-induced B-cell lymphomasHigh expression of NQO1 is associated with poor prognosis in serous ovarian carcinoma.Elevation of cellular BPDE uptake by human cells: a possible factor contributing to co-carcinogenicity by arseniteRegulation of urokinase receptor expression by p53: novel role in stabilization of uPAR mRNA.Resveratrol: Biological and pharmaceutical properties as anticancer molecule.Disruption of NAD(P)H:quinone oxidoreductase 1 gene in mice leads to radiation-induced myeloproliferative disease.Preferential utilization of NADPH as the endogenous electron donor for NAD(P)H:quinone oxidoreductase 1 (NQO1) in intact pulmonary arterial endothelial cells.NAD(P)H: quinone oxidoreductase 1 and NRH:quinone oxidoreductase 2 polymorphisms in papillary thyroid microcarcinoma: correlation with phenotype.Calcium and calcium sensing receptor modulates the expression of thymidylate synthase, NAD(P)H:quinone oxidoreductase 1 and survivin in human colon carcinoma cells: promotion of cytotoxic response to mitomycin C and fluorouracil.The aryl hydrocarbon receptor nuclear translocator (Arnt) is required for tumor initiation by benzo[a]pyrene.Genetic polymorphism in metabolism and host defense enzymes: implications for human health risk assessment.Cytochrome P450-mediated pulmonary metabolism of carcinogens: regulation and cross-talk in lung carcinogenesis.Expression of NAD(P)H quinone dehydrogenase 1 (NQO1) is increased in the endometrium of women with endometrial cancer and women with polycystic ovary syndrome.DNA damage signalling barrier, oxidative stress and treatment-relevant DNA repair factor alterations during progression of human prostate cancer.Phytochemicals for the Prevention of Photocarcinogenesis.Stress-induced NQO1 controls stability of C/EBPα against 20S proteasomal degradation to regulate p63 expression with implications in protection against chemical-induced skin cancer.CO/HO-1 Induces NQO-1 Expression via Nrf2 Activation.Functions of NQO1 in Cellular Protection and CoQ10 Metabolism and its Potential Role as a Redox Sensitive Molecular Switch.Elevated ornithine decarboxylase activity promotes skin tumorigenesis by stimulating the recruitment of bulge stem cells but not via toxic polyamine catabolic metabolites.NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer.Altered gene expression profiles in the lungs of benzo[a]pyrene-exposed mice in the presence of lipopolysaccharide-induced pulmonary inflammation.Genetic deletion of NAD(P)H:quinone oxidoreductase 1 abrogates activation of nuclear factor-kappaB, IkappaBalpha kinase, c-Jun N-terminal kinase, Akt, p38, and p44/42 mitogen-activated protein kinases and potentiates apoptosis.Overexpression of CYB5R3 and NQO1, two NAD+ -producing enzymes, mimics aspects of caloric restriction.
P2860
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P2860
Lower induction of p53 and decreased apoptosis in NQO1-null mice lead to increased sensitivity to chemical-induced skin carcinogenesis.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
Lower induction of p53 and dec ...... l-induced skin carcinogenesis.
@en
Lower induction of p53 and dec ...... l-induced skin carcinogenesis.
@nl
type
label
Lower induction of p53 and dec ...... l-induced skin carcinogenesis.
@en
Lower induction of p53 and dec ...... l-induced skin carcinogenesis.
@nl
prefLabel
Lower induction of p53 and dec ...... l-induced skin carcinogenesis.
@en
Lower induction of p53 and dec ...... l-induced skin carcinogenesis.
@nl
P2093
P1433
P1476
Lower induction of p53 and dec ...... l-induced skin carcinogenesis.
@en
P2093
Amos Gaikwad
Anil K Jaiswal
Cory Brayton
Delwin J Long
Karim Iskander
Marilene Paquet
Roberto Barrios
P304
P356
10.1158/0008-5472.CAN-04-3157
P407
P577
2005-03-01T00:00:00Z