In silico and in vitro pharmacogenetics: aldehyde oxidase rapidly metabolizes a p38 kinase inhibitor.
about
A cellular genetics approach identifies gene-drug interactions and pinpoints drug toxicity pathway nodesCd14 SNPs regulate the innate immune response.Predicting intrinsic clearance for drugs and drug candidates metabolized by aldehyde oxidase.Absolute quantification of aldehyde oxidase protein in human liver using liquid chromatography-tandem mass spectrometryIncreasing recognition of the importance of aldehyde oxidase in drug development and discovery.Critical review of p38 MAP kinase inhibitors: a bioanalytical perspective.Strategies for a comprehensive understanding of metabolism by aldehyde oxidase.Aldehyde oxidase and its importance in novel drug discovery: present and future challenges.Chimeric mice transplanted with human hepatocytes as a model for prediction of human drug metabolism and pharmacokinetics.The role of drug metabolizing enzymes in clearance.Continuous Intestinal Absorption Model Based on the Convection-Diffusion Equation.Challenges and Opportunities with Non-CYP Enzymes Aldehyde Oxidase, Carboxylesterase, and UDP-Glucuronosyltransferase: Focus on Reaction Phenotyping and Prediction of Human Clearance.An overview of aldehyde oxidase: an enzyme of emerging importance in novel drug discovery.Pyrido[3,4-d]pyrimidin-4(3H)-one metabolism mediated by aldehyde oxidase is blocked by C2-substitutionNext-generation computational genetic analysis: multiple complement alleles control survival after Candida albicans infection.A better prognosis for genetic association studies in mice.ecoAO: A Simple System for the Study of Human Aldehyde Oxidases Role in Drug Metabolism.Structure-metabolism relationships in human-AOX: Chemical insights from a large database of aza-aromatic and amide compounds.Cytochrome P450 and Non-Cytochrome P450 Oxidative Metabolism: Contributions to the Pharmacokinetics, Safety, and Efficacy of Xenobiotics.A novel in vitro allometric scaling methodology for aldehyde oxidase substrates to enable selection of appropriate species for traditional allometry.Lack of Exposure in a First-in-Man Study Due to Aldehyde Oxidase Metabolism: Investigated by Use of 14C-microdose, Humanized Mice, Monkey Pharmacokinetics, and In Vitro Methods.Species differences in metabolism of ripasudil (K-115) are attributed to aldehyde oxidase.Identification of cryptolepine metabolites in rat and human hepatocytes and metabolism and pharmacokinetics of cryptolepine in Sprague Dawley rats.Interspecies variation in the metabolism of zoniporide by aldehyde oxidase.Xenobiotica-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models
P2860
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P2860
In silico and in vitro pharmacogenetics: aldehyde oxidase rapidly metabolizes a p38 kinase inhibitor.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh-hant
name
In silico and in vitro pharmac ...... olizes a p38 kinase inhibitor.
@en
In silico and in vitro pharmac ...... olizes a p38 kinase inhibitor.
@nl
type
label
In silico and in vitro pharmac ...... olizes a p38 kinase inhibitor.
@en
In silico and in vitro pharmac ...... olizes a p38 kinase inhibitor.
@nl
prefLabel
In silico and in vitro pharmac ...... olizes a p38 kinase inhibitor.
@en
In silico and in vitro pharmac ...... olizes a p38 kinase inhibitor.
@nl
P2093
P2860
P356
P1476
In silico and in vitro pharmac ...... olizes a p38 kinase inhibitor.
@en
P2093
M Monshouwer
P2860
P2888
P356
10.1038/TPJ.2010.8
P577
2010-02-23T00:00:00Z