Structure and inhibition of the human cell cycle checkpoint kinase, Wee1A kinase: an atypical tyrosine kinase with a key role in CDK1 regulation.
about
Comparative analysis of the kinomes of three pathogenic trypanosomatids: Leishmania major, Trypanosoma brucei and Trypanosoma cruzi.Mechanisms of drug resistance in kinases.Wee1 inhibition potentiates Wip1-dependent p53-negative tumor cell death during chemotherapyA bifunctional regulatory element in human somatic Wee1 mediates cyclin A/Cdk2 binding and Crm1-dependent nuclear export.Vascular endothelial growth factor (VEGF) and platelet (PF-4) factor 4 inputs modulate human microvascular endothelial signaling in a three-dimensional matrix migration context.Activation domain-dependent degradation of somatic Wee1 kinaseStructural basis for the modulation of CDK-dependent/independent activity of cyclin D1.Identification of a Wee1-like kinase gene essential for procyclic Trypanosoma brucei survival.Genetic inhibition of the atypical kinase Wee1 selectively drives apoptosis of p53 inactive tumor cellsThe involvement of Nek2 and Notch in the proliferation of rat adrenal cortex triggered by POMC-derived peptides.Mechanism for inactivation of the mitotic inhibitory kinase Wee1 at M phase.Wee-1 kinase inhibition overcomes cisplatin resistance associated with high-risk TP53 mutations in head and neck cancer through mitotic arrest followed by senescence.Identification of Phosphorylated Cyclin-Dependent Kinase 1 Associated with Colorectal Cancer Survival Using Label-Free Quantitative Analyses.Wee-1 Kinase Inhibition Sensitizes High-Risk HPV+ HNSCC to Apoptosis Accompanied by Downregulation of MCl-1 and XIAP Antiapoptotic Proteins.Combination therapy targeting the Chk1 and Wee1 kinases shows therapeutic efficacy in neuroblastoma.Emerging cell-cycle inhibitors for pancreatic cancer therapy.Human immunodeficiency virus type 1 Vpr binds to the N lobe of the Wee1 kinase domain and enhances kinase activity for CDC2WEE1 murine deficiency induces hyper-activation of APC/C and results in genomic instability and carcinogenesisPyrimidine-based tricyclic molecules as potent and orally efficacious inhibitors of wee1 kinase.Analysis of Phosphorylation of the Receptor-Like Protein Kinase HAESA during Arabidopsis Floral Abscission.Handling ligands with Coot.The Cdk inhibitor flavopiridol enhances temozolomide-induced cytotoxicity in human glioma cells.Replication Stress Leading to Apoptosis within the S-phase Contributes to Synergism between Vorinostat and AZD1775 in HNSCC Harboring High-Risk TP53 Mutation.New therapeutic strategies to treat human cancers expressing mutant p53 proteins.Flat and Easy: 2D Depiction of Protein-Ligand Complexes.Targeting the DNA Damage Response in OSCC with TP53 Mutations.
P2860
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P2860
Structure and inhibition of the human cell cycle checkpoint kinase, Wee1A kinase: an atypical tyrosine kinase with a key role in CDK1 regulation.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Structure and inhibition of th ...... a key role in CDK1 regulation.
@en
Structure and inhibition of th ...... a key role in CDK1 regulation.
@nl
type
label
Structure and inhibition of th ...... a key role in CDK1 regulation.
@en
Structure and inhibition of th ...... a key role in CDK1 regulation.
@nl
prefLabel
Structure and inhibition of th ...... a key role in CDK1 regulation.
@en
Structure and inhibition of th ...... a key role in CDK1 regulation.
@nl
P1433
P1476
Structure and inhibition of th ...... a key role in CDK1 regulation.
@en
P2093
Ivan Ivanovic
James M Dickson
P304
P356
10.1016/J.STR.2004.12.017
P577
2005-04-01T00:00:00Z