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Structure of the first parallel DNA quadruplex-drug complexIn vitro studies with methylproamine: a potent new radioprotectorHigh-resolution crystal structure of plant carboxylesterase AeCXE1, from Actinidia eriantha, and its complex with a high-affinity inhibitor paraoxonStructures of the dimerization domains of the Escherichia coli disulfide-bond isomerase enzymes DsbC and DsbGSynthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinasesSynthesis and structure-activity relationships of soluble 8-substituted 4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinasesCrystal structures of F420-dependent glucose-6-phosphate dehydrogenase FGD1 involved in the activation of the anti-tuberculosis drug candidate PA-824 reveal the basis of coenzyme and substrate bindingStructure and function of GlmU fromMycobacterium tuberculosisStructures of glycinamide ribonucleotide transformylase (PurN) from Mycobacterium tuberculosis reveal a novel dimer with relevance to drug discoveryCrystal Structures of Three Classes of Non-Steroidal Anti-Inflammatory Drugs in Complex with Aldo-Keto Reductase 1C3Removal of the C-terminal regulatory domain of α-isopropylmalate synthase disrupts functional substrate bindingThe high-resolution crystal structure of a parallel intermolecular DNA G-4 quadruplex/drug complex employing syn glycosyl linkagesStructure of AKR1C3 with 3-phenoxybenzoic acid boundAutocatalytically generated Thr-Gln ester bond cross-links stabilize the repetitive Ig-domain shaft of a bacterial cell surface adhesinThe 1.65 Å resolution structure of the complex of AZD4547 with the kinase domain of FGFR1 displays exquisite molecular recognitionBinding mode of the breakthrough inhibitor AZD9291 to epidermal growth factor receptor revealedRadiation Damage and Racemic Protein Crystallography Reveal the Unique Structure of the GASA/Snakin Protein SuperfamilyMinor groove binding of a bis-quaternary ammonium compound: the crystal structure of SN 7167 bound to d(CGCGAATTCGCG)2Poxviral ankyrin proteinsMechanistic and Evolutionary Insights from the Reciprocal Promiscuity of Two Pyridoxal Phosphate-dependent Enzymes.Activation domain-dependent degradation of somatic Wee1 kinaseStructure of Escherichia coli UDP-N-acetylmuramoyl:L-alanine ligase (MurC).Expression, purification and crystallization of native and selenomethionine labeled Mycobacterium tuberculosis FGD1 (Rv0407) using a Mycobacterium smegmatis expression system.Defining the potassium binding region in an apple terpene synthase.Discovery and characterisation of hydrazines as inhibitors of the immune suppressive enzyme, indoleamine 2,3-dioxygenase 1 (IDO1).Trapping HIV-1 reverse transcriptase before and after translocation on DNA.Self-generated covalent cross-links in the cell-surface adhesins of Gram-positive bacteria.Cloning, expression, purification, crystallization and preliminary X-ray studies of the C-terminal domain of Rv3262 (FbiB) from Mycobacterium tuberculosis.Elongation of the Poly-γ-glutamate Tail of F420 Requires Both Domains of the F420:γ-Glutamyl Ligase (FbiB) of Mycobacterium tuberculosis.Total Chemical Synthesis of an Orf Virus Protein, ORFV002, an Inhibitor of the Master Gene Regulator NF-κB.Engineering a Lys-Asn isopeptide bond into an immunoglobulin-like protein domain enhances its stability.Preparation of truncated orf virus entry fusion complex proteins by chemical synthesis.Crystallization and preliminary X-ray analysis of alpha-isopropylmalate synthase from Mycobacterium tuberculosis.Structure and inhibition of the human cell cycle checkpoint kinase, Wee1A kinase: an atypical tyrosine kinase with a key role in CDK1 regulation.Harnessing ester bond chemistry for protein ligation.Crystal and NMR Structures of a Peptidomimetic β-Turn That Provides Facile Synthesis of 13-Membered Cyclic Tetrapeptides.2-Oxo-3, 4-dihydropyrimido[4, 5-d]pyrimidinyl derivatives as new irreversible pan fibroblast growth factor receptor (FGFR) inhibitors.Bioinspired Total Synthesis and Stereochemical Revision of the Fungal Metabolite Pestalospirane B.MCR-1: a promising target for structure-based design of inhibitors to tackle polymyxin resistanceChemical synthesis of γ-secretase activating protein using pseudoglutamines as ligation sites
P50
Q27640870-5CDC7720-F0CD-4D4C-A94A-C80779976E5CQ27643111-E4563715-1272-4BA8-A340-2CC42194A7FAQ27643669-105C3EB9-5D4A-4097-8188-E9E3E1146D73Q27644128-D79DA800-A622-4384-A537-168FC6077892Q27648179-B5335468-D7EC-4078-BFF7-67573A257450Q27649530-D014DB04-12EC-4FAF-849F-9594EAD0F3E6Q27650432-92A252C3-ADD7-4767-AB88-481E35D8F526Q27653924-0C496853-3657-4CF3-BAC5-D606804D15C5Q27655261-CFFDBEF1-209D-4AA4-BE5F-726B70F35216Q27671816-D905CD42-FCDF-4792-B446-187711199A52Q27677395-3964B806-ECCE-416A-8AD2-CE0920032FFBQ27677528-98457540-D654-4AF8-A417-993517BE439EQ27678541-0BDE880A-AFD3-48A1-86E9-116704F1CB56Q27680906-F642233F-4E43-42E2-8F15-8968F088B1D9Q27698320-3E1C90AF-404A-420F-AC9A-9EF9D6AA9EEFQ27702546-15C371F8-867C-4E6B-9433-AAD99D566513Q27704821-CF6FD27A-F5D8-4B63-8570-C09F00C85CBAQ27745513-221616F0-A765-4D86-BAB6-40D840EDAB0FQ28083265-36F78B25-44DF-4201-BCE0-AD572C45C043Q30391193-56D59256-3714-429D-A5E1-DB2CBE884521Q33673861-D946367D-AD5B-42E3-9FAE-92383BE7D3B5Q34586308-B6F39218-6843-4B4D-88E4-921DBDE5E084Q34610931-9C00396C-CA26-42FD-A9E0-5FD83F6B458CQ34933472-B7936BD7-EF30-4A44-91A9-8715D756CA4BQ35050032-C5221907-3877-4732-9F80-57D7B1EFF230Q38358259-C355BF85-A56C-49EB-895F-DDB5A5209304Q38620508-D1727D35-8340-40F2-984D-A4A1C2B5F709Q39012412-C37EBCF8-BDD2-4B34-885C-33F283576EA1Q39483290-C255CF12-B668-4DE6-9CF9-398747B66F1FQ40050020-D343EEEC-7D43-4CDB-9DF8-F11B62D2DD22Q42222432-1BB2174D-E1FE-42A6-890C-3BC4FF2C4134Q42229989-C33B2C4E-3C25-4D7B-8035-5B14ACEB892CQ42627875-D1751B9A-4F1E-45A6-A915-8BA024853FD8Q46443077-73328F26-6B5D-4E38-B8E8-C875CD980E66Q48355001-52C4DEF6-5DBA-415F-9298-CC8DAB6837FEQ48369900-B69AE024-57C5-454D-9072-0E29CB1AA7ACQ50994509-447F6E05-C9C3-45FD-A70F-6D2FA5C41C4AQ53216388-A421EFC4-06B8-4C5B-B203-1DEB03047895Q56029974-F889FF6B-385A-4D9A-90D1-47A7E3E41B78Q59407364-8F8F7F81-9351-45FC-9F33-643540E0E4AA
P50
description
onderzoeker
@nl
researcher, ORCID id # 0000-0001-9212-0461
@en
name
Christopher J Squire
@ast
Christopher J Squire
@en
Christopher J Squire
@es
Christopher J Squire
@nl
type
label
Christopher J Squire
@ast
Christopher J Squire
@en
Christopher J Squire
@es
Christopher J Squire
@nl
prefLabel
Christopher J Squire
@ast
Christopher J Squire
@en
Christopher J Squire
@es
Christopher J Squire
@nl
P106
P1153
7004214060
P21
P31
P496
0000-0001-9212-0461