In situ selection of lead compounds by click chemistry: target-guided optimization of acetylcholinesterase inhibitors.
about
Crosslinking studies of protein-protein interactions in nonribosomal peptide biosynthesisBiotin Protein Ligase Is a Target for New AntibacterialsIn situ click chemistry: from small molecule discovery to synthetic antibodiesA virtual screen discovers novel, fragment-sized inhibitors of Mycobacterium tuberculosis InhAConformational Remodeling of Femtomolar Inhibitor−Acetylcholinesterase Complexes in the Crystalline StateStereo- and regioselective azide/alkyne cycloadditions in carbonic anhydrase II via tethering, monitored by crystallography and mass spectrometryObservation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitorTargeting mRNA for Alzheimer's and related dementias.Kinetic target-guided synthesis in drug discovery and chemical biology: a comprehensive facts and figures surveyCome-back of phenanthridine and phenanthridinium derivatives in the 21st centuryAutoClickChem: click chemistry in silicoProbing gorge dimensions of cholinesterases by freeze-frame click chemistry.Tailored polymer-supported templates in dynamic combinatorial libraries: simultaneous selection, amplification and isolation of synthetic receptors.Bcl-XL-templated assembly of its own protein-protein interaction modulator from fragments decorated with thio acids and sulfonyl azides.Fragment-based screening using surface plasmon resonance technology.Synthesis of phenanthridinones via palladium-catalyzed C(sp2)-H aminocarbonylation of unprotected o-arylanilines.Selective gamma-ketoaldehyde scavengers protect Nav1.5 from oxidant-induced inactivation.In situ click chemistry generation of cyclooxygenase-2 inhibitors.Peptide and glycopeptide dendrimers and analogous dendrimeric structures and their biomedical applications.Screening of protein-protein interaction modulators via sulfo-click kinetic target-guided synthesisAn integrated microfluidic device for large-scale in situ click chemistry screening.Recent development of two chitinase inhibitors, Argifin and Argadin, produced by soil microorganisms.Click chemistry for (18)F-labeling of RGD peptides and microPET imaging of tumor integrin alphavbeta3 expression1,2,3-Triazole-heme interactions in cytochrome P450: functionally competent triazole-water-heme complexes.Protein-Templated Fragment Ligations-From Molecular Recognition to Drug Discovery.In situ click chemistry: a powerful means for lead discovery.Rigidified clicked dimeric ligands for studying the dynamics of the PDZ1-2 supramodule of PSD-95.Discovery of Bivalent Kinase Inhibitors via Enzyme-Templated Fragment ElaborationRefinement of structural leads for centrally acting oxime reactivators of phosphylated cholinesterases.Novel Triazole-Quinoline Derivatives as Selective Dual Binding Site Acetylcholinesterase Inhibitors.Dynamic thiol exchange with β-sulfido-α,β-unsaturated carbonyl compounds and dithianes.Targeting acetylcholinesterase to treat neurodegeneration.Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepineIdentification of protein targets of 4-hydroxynonenal using click chemistry for ex vivo biotinylation of azido and alkynyl derivatives.Asymmetric 1,3-dipolar cycloadditions of acrylamides.Probing secondary interactions in biomolecular recognition by dynamic combinatorial chemistry.A toxic RNA catalyzes the in cellulo synthesis of its own inhibitor.New insights into the kinetic target-guided synthesis of protein ligands.Ribosome-Templated Azide-Alkyne Cycloadditions: Synthesis of Potent Macrolide Antibiotics by In Situ Click Chemistry.Synthesis and cytotoxicity evaluation of some novel thiazoles, thiadiazoles, and pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-ones incorporating triazole moiety.
P2860
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P2860
In situ selection of lead compounds by click chemistry: target-guided optimization of acetylcholinesterase inhibitors.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
In situ selection of lead comp ...... etylcholinesterase inhibitors.
@en
In situ selection of lead comp ...... etylcholinesterase inhibitors.
@nl
type
label
In situ selection of lead comp ...... etylcholinesterase inhibitors.
@en
In situ selection of lead comp ...... etylcholinesterase inhibitors.
@nl
prefLabel
In situ selection of lead comp ...... etylcholinesterase inhibitors.
@en
In situ selection of lead comp ...... etylcholinesterase inhibitors.
@nl
P2093
P356
P1476
In situ selection of lead comp ...... etylcholinesterase inhibitors.
@en
P2093
Antoni Krasiński
Hartmuth C Kolb
Jessica Raushel
Palmer Taylor
Roman Manetsch
Zoran Radić
P304
P356
10.1021/JA043031T
P407
P577
2005-05-01T00:00:00Z