Phosphorylation, lipid raft interaction and traffic of alpha-synuclein in a yeast model for Parkinson.
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alpha-Synuclein and neuronal cell deathPhysicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)Exploring the accessible conformations of N-terminal acetylated α-synucleinThe benefits of humanized yeast models to study Parkinson's diseasePhosphorylation modulates clearance of alpha-synuclein inclusions in a yeast model of Parkinson's diseaseThe phosphorylation of α-synuclein: development and implication for the mechanism and therapy of the Parkinson's diseaseThe biological functions of Naa10 - From amino-terminal acetylation to human diseaseNew arylthioindoles and related bioisosteres at the sulfur bridging group. 4. Synthesis, tubulin polymerization, cell growth inhibition, and molecular modeling studies.The first N-terminal amino acids of alpha-synuclein are essential for alpha-helical structure formation in vitro and membrane binding in yeast.Modeling Huntington disease in yeast: perspectives and future directions.Synphilin-1 enhances α-synuclein aggregation in yeast and contributes to cellular stress and cell death in a Sir2-dependent mannerDeuterium NMR study of the effect of ergosterol on POPE membranesIdentification of novel α-synuclein isoforms in human brain tissue by using an online nanoLC-ESI-FTICR-MS methodPhosphatidylethanolamine deficiency disrupts α-synuclein homeostasis in yeast and worm models of Parkinson diseaseYeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons.Heat-mediated enrichment of α-synuclein from cells and tissue for assessing post-translational modifications.Alpha-synuclein function and dysfunction on cellular membranes.Mammalian ribosomal and chaperone protein RPS3A counteracts α-synuclein aggregation and toxicity in a yeast model system.Expression of mutant alpha-synuclein modulates microglial phenotype in vitroLipid raft redox signaling: molecular mechanisms in health and disease.Aggregation of α-synuclein in S. cerevisiae is associated with defects in endosomal trafficking and phospholipid biosynthesis.Alpha-synuclein interacts with Glucocerebrosidase providing a molecular link between Parkinson and Gaucher diseasesThe toxicity of an "artificial" amyloid is related to how it interacts with membranes.Suppression of α-synuclein toxicity and vesicle trafficking defects by phosphorylation at S129 in yeast depends on genetic context.Characterization of semisynthetic and naturally Nα-acetylated α-synuclein in vitro and in intact cells: implications for aggregation and cellular properties of α-synuclein.The Ca2+/Mn2+ ion-pump PMR1 links elevation of cytosolic Ca(2+) levels to α-synuclein toxicity in Parkinson's disease models.Novel suppressors of alpha-synuclein toxicity identified using yeastTyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation.N-terminal acetylation stabilizes N-terminal helicity in lipid- and micelle-bound α-synuclein and increases its affinity for physiological membranes.Yeast unfolds the road map toward alpha-synuclein-induced cell death.A deadly spread: cellular mechanisms of α-synuclein transfer.Aggresome formation and segregation of inclusions influence toxicity of α-synuclein and synphilin-1 in yeast.Contribution of yeast models to neurodegeneration research.Dysfunction of two lysosome degradation pathways of α-synuclein in Parkinson's disease: potential therapeutic targets?Harnessing the power of yeast to unravel the molecular basis of neurodegeneration.Protein phosphorylation in neurodegeneration: friend or foe?Ubiquitin-dependent proteolysis in yeast cells expressing neurotoxic proteins.Posttranslational Modifications and Clearing of α-Synuclein Aggregates in YeastA new role for α-synuclein in Parkinson's disease: Alteration of ER-mitochondrial communication.How to bake a brain: yeast as a model neuron.
P2860
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P2860
Phosphorylation, lipid raft interaction and traffic of alpha-synuclein in a yeast model for Parkinson.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh-hant
name
Phosphorylation, lipid raft in ...... n a yeast model for Parkinson.
@en
Phosphorylation, lipid raft in ...... n a yeast model for Parkinson.
@nl
type
label
Phosphorylation, lipid raft in ...... n a yeast model for Parkinson.
@en
Phosphorylation, lipid raft in ...... n a yeast model for Parkinson.
@nl
altLabel
Phosphorylation, lipid raft in ...... in a yeast model for Parkinson
@en
prefLabel
Phosphorylation, lipid raft in ...... n a yeast model for Parkinson.
@en
Phosphorylation, lipid raft in ...... n a yeast model for Parkinson.
@nl
P2093
P921
P1476
Phosphorylation, lipid raft in ...... n a yeast model for Parkinson.
@en
P2093
Fred Van Leuven
Ilse Bastiaens
Joris Winderickx
Klaartje Pellens
Piotr Zabrocki
Ruben Ghillebert
Tine Bammens
P304
P356
10.1016/J.BBAMCR.2008.06.010
P577
2008-06-19T00:00:00Z