Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells. - Wikidata - wikimedia - TriplyDB

Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells.

Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells.

http://www.wikidata.org/entity/Q46531701

about

Notch1 augments NF-kappaB activity by facilitating its nuclear retention Oligodendrocyte Injury and Pathogenesis of HIV-1-Associated Neurocognitive Disorders KSHV-Mediated Angiogenesis in Tumor Progression KSHV Genome Replication and Maintenance Lessons learned from next-generation sequencing in head and neck cancer Cancer Stem and Progenitor-Like Cells as Pharmacological Targets in Breast Cancer Treatment KSHV reactivation and novel implications of protein isomerization on lytic switch control N-acetylcysteine negatively regulates Notch3 and its malignant signaling γ-Secretase inhibitor enhances antitumour effect of radiation in Notch-expressing lung cancer Alterations in the Notch4 pathway in cerebral endothelial cells by the HIV aspartyl protease inhibitor, nelfinavir.KSHV manipulates Notch signaling by DLL4 and JAG1 to alter cell cycle genes in lymphatic endothelia Notch3 cooperates with the EGFR pathway to modulate apoptosis through the induction of bim.KSHV-induced notch components render endothelial and mural cell characteristics and cell survival.ALDH+ tumor-initiating cells exhibiting gain in NOTCH1 gene copy number have enhanced regrowth sensitivity to a γ-secretase inhibitor and irinotecan in colorectal cancer Clinical impact of de-regulated Notch-1 and Notch-3 in the development and progression of HPV-associated different histological subtypes of precancerous and cancerous lesions of human uterine cervix.γ-secretase inhibitor DAPT sensitizes t-AUCB-induced apoptosis of human glioblastoma cells in vitro via blocking the p38 MAPK/MAPKAPK2/Hsp27 pathway Notch-1 inhibition by Withaferin-A: a therapeutic target against colon carcinogenesis.Notch signaling contributes to proliferation and tumor formation of human T-cell leukemia virus type 1-associated adult T-cell leukemia.Conditional ablation of Ezh2 in murine hearts reveals its essential roles in endocardial cushion formation, cardiomyocyte proliferation and survival.Opposing regulation of PROX1 by interleukin-3 receptor and NOTCH directs differential host cell fate reprogramming by Kaposi sarcoma herpes virus.Activation of Notch signaling pathway in HIV-associated nephropathy.Notch signaling proteins: legitimate targets for cancer therapy.Identification of 11-amino acid peptides that disrupt Notch-mediated processes in Drosophila.Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches Restoration of p53 expression in human cancer cell lines upregulates the expression of Notch1: implications for cancer cell fate determination after genotoxic stress Oncogenesis and cancer stem cells: current opinions and future directions.The viral interferon regulatory factors of KSHV: immunosuppressors or oncogenes?Matrix metalloproteinase 9 induces endothelial-mesenchymal transition via Notch activation in human kidney glomerular endothelial cells Therapeutic approaches to modulating Notch signaling: current challenges and future prospects.Fine-Tuning of the Kaposi's Sarcoma-Associated Herpesvirus Life Cycle in Neighboring Cells through the RTA-JAG1-Notch Pathway.KSHV viral cyclin interferes with T-cell development and induces lymphoma through Cdk6 and Notch activation in vivo Kaposi sarcoma herpesvirus promotes endothelial-to-mesenchymal transition through Notch-dependent signaling.Kaposi's sarcoma and its associated herpesvirus.Deleting the TGF-β receptor in proximal tubules impairs HGF signaling Notch signalling pathways mediate synovial angiogenesis in response to vascular endothelial growth factor and angiopoietin 2 Mechanisms and clinical prospects of Notch inhibitors in the therapy of hematological malignancies.Differential gene expression in the perichondrium and cartilage of the neonatal mouse temporomandibular joint.Active Notch1 confers a transformed phenotype to primary human melanocytes.Pancreatic cancer stem cells: fact or fiction?Prolactin signaling enhances colon cancer stemness by modulating Notch signaling in a Jak2-STAT3/ERK manner.

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P2860

Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells.

http://www.wikidata.org/entity/Q46531701

description

2005 nî lūn-bûn

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2005年の論文

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2005年学术文章

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2005年学术文章

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2005年学术文章

@zh-cn

2005年学术文章

@zh-hans

2005年学术文章

@zh-my

2005年学术文章

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2005年學術文章

@yue

2005年學術文章

@zh-hant

name

Gamma secretase inhibitor bloc ...... Kaposi's sarcoma tumor cells.

@en

Gamma secretase inhibitor bloc ...... Kaposi's sarcoma tumor cells.

@nl

type

label

Gamma secretase inhibitor bloc ...... Kaposi's sarcoma tumor cells.

@en

Gamma secretase inhibitor bloc ...... Kaposi's sarcoma tumor cells.

@nl

prefLabel

Gamma secretase inhibitor bloc ...... Kaposi's sarcoma tumor cells.

@en

Gamma secretase inhibitor bloc ...... Kaposi's sarcoma tumor cells.

@nl

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P1476

Gamma secretase inhibitor bloc ...... Kaposi's sarcoma tumor cells.

@en

P2093

Brian J Nickoloff

http://www.w3.org/2001/XMLSchema#string

Kimberly E Foreman

http://www.w3.org/2001/XMLSchema#string

Laura L Reed

http://www.w3.org/2001/XMLSchema#string

Todd E Golde

http://www.w3.org/2001/XMLSchema#string

P2860

Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes

HES and HERP families: multiple effectors of the Notch signaling pathway

HERP1 is a cell type-specific primary target of Notch

Alterations in Notch signaling in neoplastic lesions of the human cervix.

Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen induces expression of the helix-loop-helix protein Id-1 in human endothelial cells.

Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles

Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation.

HPV16 E6 and E7 oncoproteins regulate Notch-1 expression and cooperate to induce transformation.

Studies of Abeta pharmacodynamics in the brain, cerebrospinal fluid, and plasma in young (plaque-free) Tg2576 mice using the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[

Presenilin-directed inhibitors of gamma-secretase trigger caspase 3 activation in presenilin-expressing and presenilin-deficient cells.

P2888

P304

6333-6344

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scholarly article

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10.1038/SJ.ONC.1208783

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P433

42

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24

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Christine L Curry

P577

2005-09-01T00:00:00Z

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7802605

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15940249

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