Therapeutic approaches to modulating Notch signaling: current challenges and future prospects.
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Targeting the Notch signaling pathway in cancer therapeuticsEmerging therapeutic biomarkers in endometrial cancerStructural Analysis Uncovers Lipid-Binding Properties of Notch LigandsExpression profiling of stem cell-related genes in neoadjuvant-treated gastric cancer: a NOTCH2, GSK3B and β-catenin gene signature predicts survivalΓ-secretase components as predictors of breast cancer outcomeProtein trafficking abnormalities in Drosophila tissues with impaired activity of the ZIP7 zinc transporter CatsupNeighbours of cancer-related proteins have key influence on pathogenesis and could increase the drug target space for anticancer therapiesMorphogen pathways as molecular targets for the treatment of fibrosis in systemic sclerosis.Notch signaling in pediatric soft tissue sarcomasThe role of epithelial plasticity in prostate cancer dissemination and treatment resistanceRegulation of progenitor cell proliferation and neuronal differentiation in enteric nervous system neurospheres.Concerning consequences of blocking Notch signaling in satellite muscle stem cellsThe truncate mutation of Notch2 enhances cell proliferation through activating the NF-κB signal pathway in the diffuse large B-cell lymphomas.Extending in silico mechanism-of-action analysis by annotating targets with pathways: application to cellular cytotoxicity readouts.The spectrum of genetic defects in chronic lymphocytic leukemia.Sonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cells.Inhibition of Notch pathway attenuates the progression of human immunodeficiency virus-associated nephropathy.Notch signaling pathway targeted therapy suppresses tumor progression and metastatic spread in pancreatic cancer.Prediabetic changes in gene expression induced by aspartame and monosodium glutamate in Trans fat-fed C57Bl/6 J miceAn activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth.Notch-1 Confers Chemoresistance in Lung Adenocarcinoma to Taxanes through AP-1/microRNA-451 Mediated Regulation of MDR-1.A Novel Assay for the Identification of NOTCH1 PEST Domain Mutations in Chronic Lymphocytic Leukemia.Hypoxia, notch signalling, and prostate cancer.NUMB inhibition of NOTCH signalling as a therapeutic target in prostate cancer.Circulating-free DNA Mutation Associated with Response of Targeted Therapy in Human Epidermal Growth Factor Receptor 2-positive Metastatic Breast CancerMolecular genetics of high-risk chronic lymphocytic leukemia.Notch signaling in pancreatic cancer: oncogene or tumor suppressor?Novel targeted therapies in acute lymphoblastic leukemia.The therapeutic potential of targeting the epithelial-mesenchymal transition in cancer.Therapeutic modulation of Notch signalling--are we there yet?Significance of glycosylation in Notch signaling.Clofarabine for the treatment of adult acute lymphoid leukemia: the Group for Research on Adult Acute Lymphoblastic Leukemia intergroup.Evolving understanding of the CLL genome.The complex role of NOTCH receptors and their ligands in the development of hepatoblastoma, cholangiocarcinoma and hepatocellular carcinoma.Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligandsTargeting of miR9/NOTCH1 interaction reduces metastatic behavior in triple-negative breast cancer.Notch is a direct negative regulator of the DNA-damage response.Activation of nuclear PTEN by inhibition of Notch signaling induces G2/M cell cycle arrest in gastric cancer.Antiproliferative effects of γ-secretase inhibitor, a Notch signalling inhibitor, in multiple myeloma cells and its molecular mechanism of action.Notch Signaling in T Helper Cell Subsets: Instructor or Unbiased Amplifier?
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Therapeutic approaches to modulating Notch signaling: current challenges and future prospects.
description
2012 nî lūn-bûn
@nan
2012年の論文
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2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Therapeutic approaches to modu ...... allenges and future prospects.
@ast
Therapeutic approaches to modu ...... allenges and future prospects.
@en
type
label
Therapeutic approaches to modu ...... allenges and future prospects.
@ast
Therapeutic approaches to modu ...... allenges and future prospects.
@en
prefLabel
Therapeutic approaches to modu ...... allenges and future prospects.
@ast
Therapeutic approaches to modu ...... allenges and future prospects.
@en
P2860
P1476
Therapeutic approaches to modu ...... hallenges and future prospects
@en
P2093
Mark E Fortini
P2860
P304
P356
10.1016/J.SEMCDB.2012.01.016
P50
P577
2012-01-30T00:00:00Z