Prolonged heterologous beta2-adrenoceptor desensitization promotes proasthmatic airway smooth muscle function via PKA/ERK1/2-mediated phosphodiesterase-4 induction.

Prolonged heterologous beta2-adrenoceptor desensitization promotes proasthmatic airway smooth muscle function via PKA/ERK1/2-mediated phosphodiesterase-4 induction.

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http://www.wikidata.org/entity/Q46687772
Can the anti-inflammatory activities of β2-agonists be harnessed in the clinical setting?Scientific rationale for the use of alpha-adrenergic agonists and glucocorticoids in the therapy of pediatric stridor.Beta-agonist-associated reduction in RGS5 expression promotes airway smooth muscle hyper-responsiveness.Constitutively active signaling by the G protein βγ-subunit mediates intrinsically increased phosphodiesterase-4 activity in human asthmatic airway smooth muscle cells.G Protein βγ-subunit signaling mediates airway hyperresponsiveness and inflammation in allergic asthma.Th2 cytokine-induced upregulation of 11beta-hydroxysteroid dehydrogenase-1 facilitates glucocorticoid suppression of proasthmatic airway smooth muscle function.Mechanism regulating proasthmatic effects of prolonged homologous beta2-adrenergic receptor desensitization in airway smooth muscle.Current concepts on the use of glucocorticosteroids and beta-2-adrenoreceptor agonists to treat childhood asthmaNovel cAMP signalling paradigms: therapeutic implications for airway diseaseMechanism of glucocorticoid protection of airway smooth muscle from proasthmatic effects of long-acting beta2-adrenoceptor agonist exposure.Rosiglitazone reverses salbutamol-induced β(2) -adrenoceptor tolerance in airway smooth muscleThe effects of acute and chronic nadolol treatment on β2AR signaling in HEK293 cells.Cyclic Adenosine Monophosphate-Mediated Enhancement of Vascular Endothelial Growth Factor Released by Differentiated Human Monocytic Cells: The Role of Protein Kinase A.PGE 2 desensitizes β -agonist effect on human lung fibroblast-mediated collagen gel contraction through upregulating PDE4.Reduced suppressive effect of β2-adrenoceptor agonist on fibrocyte function in severe asthma.PDE8 is Expressed in Human Airway Smooth Muscle and Selectively Regulates cAMP Signaling by β2AR-AC6.
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Prolonged heterologous beta2-adrenoceptor desensitization promotes proasthmatic airway smooth muscle function via PKA/ERK1/2-mediated phosphodiesterase-4 induction.

Item
http://www.wikidata.org/entity/Q46687772
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Prolonged heterologous beta2-a ...... phosphodiesterase-4 induction.
@en
Prolonged heterologous beta2-a ...... phosphodiesterase-4 induction.
@nl
type
label
Prolonged heterologous beta2-a ...... phosphodiesterase-4 induction.
@en
Prolonged heterologous beta2-a ...... phosphodiesterase-4 induction.
@nl
prefLabel
Prolonged heterologous beta2-a ...... phosphodiesterase-4 induction.
@en
Prolonged heterologous beta2-a ...... phosphodiesterase-4 induction.
@nl
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P2860
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Prolonged heterologous beta2-a ...... phosphodiesterase-4 induction.
@en
P2093
P2860
P304
P31
P356
10.1152/AJPLUNG.00021.2008
P433
P478
P577
P698