Inhibition of phosphodiesterase 4 attenuates airway hyperresponsiveness and airway inflammation in a model of secondary allergen challenge.
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PDE4 inhibitors: current statusPirfenidone modulates airway responsiveness, inflammation, and remodeling after repeated challengeAirway smooth muscle in asthma: just a target for bronchodilation?Derivation and validation of murine histologic alterations resembling asthma, with two proposed histologic grade parameters.Airway inflammation and allergen specific IgE production may persist longer than airway hyperresponsiveness in mice.Understanding asthma using animal modelsEffects of combination therapy with montelukast and carbocysteine in allergen-induced airway hyperresponsiveness and airway inflammationAsthma, airway biology, and nasal disorders in AJRCCM 2001.Phosphodiesterase 4 inhibition decreases MUC5AC expression induced by epidermal growth factor in human airway epithelial cells.The absence of mrp4 has no effect on the recruitment of neutrophils and eosinophils into the lung after LPS, cigarette smoke or allergen challenge.Biochanin a, a phytoestrogenic isoflavone with selective inhibition of phosphodiesterase 4, suppresses ovalbumin-induced airway hyperresponsiveness.Modeling allergic asthma in mice: pitfalls and opportunities.S-Petasin, the Main Sesquiterpene of Petasites formosanus, Inhibits Phosphodiesterase Activity and Suppresses Ovalbumin-Induced Airway Hyperresponsiveness.Airway hypersecretion in allergic rhinitis and asthma: new pharmacotherapy.Pulmonary mucus: Pediatric perspective.Blocking the leukotriene B4 receptor 1 inhibits late-phase airway responses in established diseaseConstitutively active signaling by the G protein βγ-subunit mediates intrinsically increased phosphodiesterase-4 activity in human asthmatic airway smooth muscle cells.Hesperetin-7,3'-O-dimethylether selectively inhibits phosphodiesterase 4 and effectively suppresses ovalbumin-induced airway hyperresponsiveness with a high therapeutic ratio.G Protein βγ-subunit signaling mediates airway hyperresponsiveness and inflammation in allergic asthma.Hesperetin, a Selective Phosphodiesterase 4 Inhibitor, Effectively Suppresses Ovalbumin-Induced Airway Hyperresponsiveness without Influencing Xylazine/Ketamine-Induced AnesthesiaHesperidin-3'-o-methylether is more potent than hesperidin in phosphodiesterase inhibition and suppression of ovalbumin-induced airway hyperresponsiveness.Administration of PDE4 inhibitors suppressed the pannus-like inflammation by inhibition of cytokine production by macrophages and synovial fibroblast proliferation.IL-18 does not increase allergic airway disease in mice when produced by BCG.1,25D3 prevents CD8(+)Tc2 skewing and asthma development through VDR binding changes to the Cyp11a1 promoter.Inhibition of neutrophil elastase attenuates airway hyperresponsiveness and inflammation in a mouse model of secondary allergen challenge: neutrophil elastase inhibition attenuates allergic airway responses.Attenuation of TNF production and experimentally induced inflammation by PDE4 inhibitor rolipram is mediated by MAPK phosphatase-1.Importance of myeloid dendritic cells in persistent airway disease after repeated allergen exposure.Airway hyperresponsiveness in the absence of CD4+ T cells after primary but not secondary challengeAirway smooth muscle as an immunomodulatory cell.Mouse models of allergic asthma: acute and chronic allergen challenge.Mechanism regulating proasthmatic effects of prolonged homologous beta2-adrenergic receptor desensitization in airway smooth muscle.Janus kinase 1/3 signaling pathways are key initiators of TH2 differentiation and lung allergic responses.Current concepts on the use of glucocorticosteroids and beta-2-adrenoreceptor agonists to treat childhood asthmaNeonatal chlamydial infection induces mixed T-cell responses that drive allergic airway disease.Quercetin acutely relaxes airway smooth muscle and potentiates β-agonist-induced relaxation via dual phosphodiesterase inhibition of PLCβ and PDE4.Can we find better bronchodilators to relieve asthma symptoms?Mechanism of glucocorticoid protection of airway smooth muscle from proasthmatic effects of long-acting beta2-adrenoceptor agonist exposure.Protection of mice from allergen-induced asthma by selenite: prevention of eosinophil infiltration by inhibition of NF-kappa B activation.A small molecule, orally active, alpha4beta1/alpha4beta7 dual antagonist reduces leukocyte infiltration and airway hyper-responsiveness in an experimental model of allergic asthma in Brown Norway rats.Effect of phosphodiesterase-5 inhibitor, sildenafil (Viagra), in animal models of airways disease.
P2860
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P2860
Inhibition of phosphodiesterase 4 attenuates airway hyperresponsiveness and airway inflammation in a model of secondary allergen challenge.
description
2001 nî lūn-bûn
@nan
2001 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Inhibition of phosphodiesteras ...... secondary allergen challenge.
@ast
Inhibition of phosphodiesteras ...... secondary allergen challenge.
@en
type
label
Inhibition of phosphodiesteras ...... secondary allergen challenge.
@ast
Inhibition of phosphodiesteras ...... secondary allergen challenge.
@en
prefLabel
Inhibition of phosphodiesteras ...... secondary allergen challenge.
@ast
Inhibition of phosphodiesteras ...... secondary allergen challenge.
@en
P2093
P2860
P1476
Inhibition of phosphodiesteras ...... secondary allergen challenge.
@en
P2093
Gelfand EW
Kanehiro A
P2860
P304
P356
10.1164/AJRCCM.163.1.2001118
P407
P577
2001-01-01T00:00:00Z