M1 receptors play a central role in modulating AD-like pathology in transgenic mice.
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Leveraging the cortical cholinergic system to enhance attentionSubtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disordersA selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learningDiscovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity.G Protein-Coupled Receptors (GPCRs) in Alzheimer's Disease: A Focus on BACE1 Related GPCRsAlzheimer's therapeutics: translation of preclinical science to clinical drug developmentBehavioral assays with mouse models of Alzheimer's disease: practical considerations and guidelines.Spines, plasticity, and cognition in Alzheimer's model miceProteomic Substrate Identification for Membrane Proteases in the BrainAlzheimer's disease: Targeting the Cholinergic SystemAlzheimer Disease: Crosstalk between the Canonical Wnt/Beta-Catenin Pathway and PPARs Alpha and GammaThe Cu, Zn Superoxide Dismutase: Not Only a Dismutase EnzymeCholinergic treatments with emphasis on m1 muscarinic agonists as potential disease-modifying agents for Alzheimer's diseaseBACE1 expression and activity: relevance in Alzheimer's diseaseRegulation of amyloid precursor protein processing by serotonin signalingThe antipsychotic potential of muscarinic allosteric modulationAllosteric activators of muscarinic receptors as novel approaches for treatment of CNS disorders.Targeting selective activation of M(1) for the treatment of Alzheimer's disease: further chemical optimization and pharmacological characterization of the M(1) positive allosteric modulator ML169.Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system.Amyloid activates GSK-3beta to aggravate neuronal tauopathy in bigenic mice.Mechanisms underlying basal and learning-related intrinsic excitability in a mouse model of Alzheimer's disease.The type I inositol 1,4,5-trisphosphate receptor interacts with protein 4.1N to mediate neurite formation through intracellular Ca wavesHippocampal Gαq/₁₁ but not Gαo-coupled receptors are altered in aging.Molecular mechanisms for Alzheimer's disease: implications for neuroimaging and therapeutics.Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moietiesTranscriptome analysis of synaptoneurosomes identifies neuroplasticity genes overexpressed in incipient Alzheimer's disease.Apolipoprotein E-mimetics inhibit neurodegeneration and restore cognitive functions in a transgenic Drosophila model of Alzheimer's diseaseThe role of Wnt signaling in the development of Alzheimer's disease: a potential therapeutic target?Allosteric Modulation of Muscarinic Acetylcholine Receptors.Presynaptic m1 muscarinic receptors are necessary for mGluR long-term depression in the hippocampusViable mouse gene ablations that robustly alter brain Aβ levels are rare.Sex steroid levels and AD-like pathology in 3xTgAD mice.Deletion of M1 muscarinic acetylcholine receptors increases amyloid pathology in vitro and in vivo.Targeting Abeta and tau in Alzheimer's disease, an early interim reportCortical M1 receptor concentration increases without a concomitant change in function in Alzheimer's disease.The secretases: enzymes with therapeutic potential in Alzheimer disease.The M3-muscarinic receptor regulates learning and memory in a receptor phosphorylation/arrestin-dependent mannerExpanding the multipotent profile of huprine-tacrine heterodimers as disease-modifying anti-Alzheimer agents.Development of allosteric modulators of GPCRs for treatment of CNS disordersCholinotrophic basal forebrain system alterations in 3xTg-AD transgenic mice.
P2860
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P2860
M1 receptors play a central role in modulating AD-like pathology in transgenic mice.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
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2006年學術文章
@zh-hant
name
M1 receptors play a central role in modulating AD-like pathology in transgenic mice.
@en
M1 receptors play a central role in modulating AD-like pathology in transgenic mice.
@nl
type
label
M1 receptors play a central role in modulating AD-like pathology in transgenic mice.
@en
M1 receptors play a central role in modulating AD-like pathology in transgenic mice.
@nl
prefLabel
M1 receptors play a central role in modulating AD-like pathology in transgenic mice.
@en
M1 receptors play a central role in modulating AD-like pathology in transgenic mice.
@nl
P2093
P1433
P1476
M1 receptors play a central role in modulating AD-like pathology in transgenic mice.
@en
P2093
Abraham Fisher
Antonella Caccamo
Frank M LaFerla
Hilda Martinez-Coria
Kim N Green
Lauren M Billings
Salvatore Oddo
P304
P356
10.1016/J.NEURON.2006.01.020
P407
P577
2006-03-01T00:00:00Z