Geldanamycin induces heat shock protein 70 and protects against MPTP-induced dopaminergic neurotoxicity in mice.
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Adaptation and mal-adaptation to ambient hypoxia; Andean, Ethiopian and Himalayan patternsChronophin mediates an ATP-sensing mechanism for cofilin dephosphorylation and neuronal cofilin-actin rod formation.Targeting heat shock proteins to modulate α-synuclein toxicityMolecular chaperones and co-chaperones in Parkinson diseaseHeat shock transcription factor 1 as a therapeutic target in neurodegenerative diseasesSynthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90Drosophila as an In Vivo Model for Human Neurodegenerative DiseaseChronic treatment with novel small molecule Hsp90 inhibitors rescues striatal dopamine levels but not α-synuclein-induced neuronal cell lossValproic acid induces functional heat-shock protein 70 via Class I histone deacetylase inhibition in cortical neurons: a potential role of Sp1 acetylationHeat shock proteins: cellular and molecular mechanisms in the central nervous system.Geldanamycin induces production of heat shock protein 70 and partially attenuates ototoxicity caused by gentamicin in the organ of Corti explantsRole of the ubiquitin proteasome system in Parkinson's disease.Synthesis and evaluation of Hsp90 inhibitors that contain the 1,4-naphthoquinone scaffold.To fold or not to fold: modulation and consequences of Hsp90 inhibition.Methylmercury alters the activities of Hsp90 client proteins, prostaglandin E synthase/p23 (PGES/23) and nNOS.Molecular chaperones and protein folding as therapeutic targets in Parkinson's disease and other synucleinopathiesGeldanamycin attenuates 3‑nitropropionic acid‑induced apoptosis and JNK activation through the expression of HSP 70 in striatal cells.Apoptosis in response to heat stress is positively associated with heat-shock protein 90 expression in chicken myocardial cells in vitroHeat shock protein 90 in neurodegenerative diseasesDownregulation of the Hsp90 system causes defects in muscle cells of Caenorhabditis elegansAnti-malaria drug blocks proteotoxic stress response: anti-cancer implications.Hsp70 and its molecular role in nervous system diseasesHeat shock protein 70 upregulation by geldanamycin reduces brain injury in a mouse model of intracerebral hemorrhage.Excessive HDAC activation is critical for neurodegeneration in the rd1 mouse.Are heat shock proteins therapeutic target for Parkinson's disease?Hsp104 suppresses polyglutamine-induced degeneration post onset in a drosophila MJD/SCA3 model.Collaboration of geldanamycin-activated P70S6K and Hsp70 against beta-amyloid-induced hippocampal apoptosis: an approach to long-term memory and learningCombined pharmacological induction of Hsp70 suppresses prion protein neurotoxicity in Drosophila.Dealing with misfolded proteins: examining the neuroprotective role of molecular chaperones in neurodegeneration.Identification and characterisation of a novel heat shock protein 90 inhibitor ONO4140.Heat shock protein-70 (Hsp-70) suppresses paraquat-induced neurodegeneration by inhibiting JNK and caspase-3 activation in Drosophila model of Parkinson's disease.Protective effects of valproic acid on the nigrostriatal dopamine system in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's diseaseMolecular chaperones in Parkinson's disease--present and futureHigh-throughput assay for the identification of Hsp90 inhibitors based on Hsp90-dependent refolding of firefly luciferase.Possible Contribution of Zerumbone-Induced Proteo-Stress to Its Anti-Inflammatory Functions via the Activation of Heat Shock Factor 1.Involvement of heat shock proteins on Mn-induced toxicity in Caenorhabditis elegans.Proteotoxic stress of cancer: implication of the heat-shock response in oncogenesis.Induction of heat shock protein 70 (Hsp70) prevents neuregulin-induced demyelination by enhancing the proteasomal clearance of c-Jun.Novel therapeutic strategies for the treatment of protein-misfolding diseases.Hsp90 inhibitor partially corrects nephrogenic diabetes insipidus in a conditional knock-in mouse model of aquaporin-2 mutation.
P2860
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P2860
Geldanamycin induces heat shock protein 70 and protects against MPTP-induced dopaminergic neurotoxicity in mice.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Geldanamycin induces heat shoc ...... inergic neurotoxicity in mice.
@en
Geldanamycin induces heat shoc ...... inergic neurotoxicity in mice.
@nl
type
label
Geldanamycin induces heat shoc ...... inergic neurotoxicity in mice.
@en
Geldanamycin induces heat shoc ...... inergic neurotoxicity in mice.
@nl
prefLabel
Geldanamycin induces heat shoc ...... inergic neurotoxicity in mice.
@en
Geldanamycin induces heat shoc ...... inergic neurotoxicity in mice.
@nl
P2093
P2860
P356
P1476
Geldanamycin induces heat shoc ...... inergic neurotoxicity in mice.
@en
P2093
Hai-Ying Shen
Jiang-Fan Chen
Jin-Cai He
Qing-Yuan Huang
Yumei Wang
P2860
P304
39962-39969
P356
10.1074/JBC.M505524200
P407
P577
2005-10-06T00:00:00Z