Overexpression of heat shock protein 70 in R6/2 Huntington's disease mice has only modest effects on disease progression.
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Targeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseasesMouse models of polyglutamine diseases in therapeutic approaches: review and data table. Part II.Therapeutic Approaches for Inhibition of Protein Aggregation in Huntington's DiseaseThe HSP70 molecular chaperone is not beneficial in a mouse model of alpha-synucleinopathyPARP-1 Inhibition Is Neuroprotective in the R6/2 Mouse Model of Huntington's DiseaseInhibition of the striatal specific phosphodiesterase PDE10A ameliorates striatal and cortical pathology in R6/2 mouse model of Huntington's diseaseThe HSP70 chaperone machinery: J proteins as drivers of functional specificityAltered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease.Protective effect of geranylgeranylacetone via enhancement of HSPB8 induction in desmin-related cardiomyopathy.To fold or not to fold: modulation and consequences of Hsp90 inhibition.cAMP-response element-binding protein and heat-shock protein 70 additively suppress polyglutamine-mediated toxicity in DrosophilaHeat shock protein 70 (hsp70) as an emerging drug target.Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease.Hsp70 and its molecular role in nervous system diseasesTargets for future clinical trials in Huntington's disease: what's in the pipeline?Hsp40 gene therapy exerts therapeutic effects on polyglutamine disease mice via a non-cell autonomous mechanism.The novel hydroxylamine derivative NG-094 suppresses polyglutamine protein toxicity in Caenorhabditis elegans.hsp72, a host determinant of measles virus neurovirulenceChaperone proteins and brain tumors: potential targets and possible therapeutics.Suppression of protein aggregation by chaperone modification of high molecular weight complexesThe use of the R6 transgenic mouse models of Huntington's disease in attempts to develop novel therapeutic strategies.Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration.Sex-dependent effect of BAG1 in ameliorating motor deficits of Huntington disease transgenic mice.Molecular chaperones as regulators of cell death.Loss of Hsp70 exacerbates pathogenesis but not levels of fibrillar aggregates in a mouse model of Huntington's disease.The heat shock factor family and adaptation to proteotoxic stress.Opportunities and challenges for molecular chaperone modulation to treat protein-conformational brain diseasesBarcoding heat shock proteins to human diseases: looking beyond the heat shock responseFrom pathways to targets: understanding the mechanisms behind polyglutamine disease.Molecular chaperones and neuronal proteostasis.Modulation of Molecular Chaperones in Huntington's Disease and Other Polyglutamine Disorders.Dexamethasone induces heat shock response and slows down disease progression in mouse and fly models of Huntington's disease.Active HSF1 significantly suppresses polyglutamine aggregate formation in cellular and mouse models.Hsp70 and Hsp40 chaperones do not modulate retinal phenotype in SCA7 mice.Proteostasis of Huntingtin in Health and DiseaseThe heat shock response in neurons and astroglia and its role in neurodegenerative diseases.Adverse outcome pathways: opportunities, limitations and open questionsElevation of the Hsp70 chaperone does not effect toxicity in mouse models of familial amyotrophic lateral sclerosis.Hsp27 overexpression in the R6/2 mouse model of Huntington's disease: chronic neurodegeneration does not induce Hsp27 activation.Geldanamycin induces heat shock protein 70 and protects against MPTP-induced dopaminergic neurotoxicity in mice.
P2860
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P2860
Overexpression of heat shock protein 70 in R6/2 Huntington's disease mice has only modest effects on disease progression.
description
2003 nî lūn-bûn
@nan
2003 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Overexpression of heat shock p ...... ffects on disease progression.
@ast
Overexpression of heat shock p ...... ffects on disease progression.
@en
type
label
Overexpression of heat shock p ...... ffects on disease progression.
@ast
Overexpression of heat shock p ...... ffects on disease progression.
@en
prefLabel
Overexpression of heat shock p ...... ffects on disease progression.
@ast
Overexpression of heat shock p ...... ffects on disease progression.
@en
P50
P1433
P1476
Overexpression of heat shock p ...... ffects on disease progression.
@en
P2093
Marja Jäättelä
Roger F Castilho
P356
10.1016/S0006-8993(02)04275-0
P407
P577
2003-04-01T00:00:00Z