DSCR1/RCAN1 regulates vesicle exocytosis and fusion pore kinetics: implications for Down syndrome and Alzheimer's disease.
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Regulation of RCAN1 protein activity by Dyrk1A protein-mediated phosphorylationEmerging roles for intersectin (ITSN) in regulating signaling and disease pathwaysSynaptic Vesicle Recycling Is Unaffected in the Ts65Dn Mouse Model of Down SyndromeRCAN1 Overexpression Exacerbates Calcium Overloading-Induced Neuronal ApoptosisNeuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain.A large-scale multi-technique approach identifies forty-nine new players of keratinocyte terminal differentiation in human epidermis.RCAN1 regulates mitochondrial function and increases susceptibility to oxidative stress in mammalian cells.Behavioral characterization of a mouse model overexpressing DSCR1/ RCAN1.Extracellular ATP activates NFAT-dependent gene expression in neuronal PC12 cells via P2X receptorsElectrically evoking and electrochemically resolving quantal release on a microchipThe use of mouse models for understanding the biology of down syndrome and agingVesicle Motion during Sustained Exocytosis in Chromaffin Cells: Numerical Model Based on Amperometric Measurements.A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes.Over-expression of DSCR1 protects against post-ischemic neuronal injuryThe calcineurin inhibitor Sarah (Nebula) exacerbates Aβ42 phenotypes in a Drosophila model of Alzheimer's disease.Rcan1 negatively regulates Fc epsilonRI-mediated signaling and mast cell function.Enhanced dense core granule function and adrenal hypersecretion in a mouse model of Rett syndrome.Allele-Specific Phenotype Suggests a Possible Stimulatory Activity of RCAN-1 on Calcineurin in Caenorhabditis elegans.Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production.Do RCAN1 proteins link chronic stress with neurodegeneration?Chronic high levels of the RCAN1-1 protein may promote neurodegeneration and Alzheimer disease.Aberrant expression of RCAN1 in Alzheimer's pathogenesis: a new molecular mechanism and a novel drug target.Exocytosis in non-neuronal cells.The nutrient-sensing repertoires of mouse enterochromaffin cells differ between duodenum and colon.Modulation of calcineurin activity in mouse brain by chronic oral administration of cyclosporine A.Mice deficient for the chromosome 21 ortholog Itsn1 exhibit vesicle-trafficking abnormalities.Electroporation followed by electrochemical measurement of quantal transmitter release from single cells using a patterned microelectrode.Serotonin-secreting enteroendocrine cells respond via diverse mechanisms to acute and chronic changes in glucose availability.Upregulation of RCAN1 causes Down syndrome-like immune dysfunction.Identification of unique release kinetics of serotonin from guinea-pig and human enterochromaffin cells.Copper modulates the large dense core vesicle secretory pathway in PC12 cells.The neuronal and endocrine roles of RCAN1 in health and disease.Fusion Pore Size Limits 5-HT Release From Single Enterochromaffin Cell Vesicles.Small molecules demonstrate the role of dynamin as a bi-directional regulator of the exocytosis fusion pore and vesicle release.Phosphatidylinositol(4,5)bisphosphate coordinates actin-mediated mobilization and translocation of secretory vesicles to the plasma membrane of chromaffin cells.
P2860
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P2860
DSCR1/RCAN1 regulates vesicle exocytosis and fusion pore kinetics: implications for Down syndrome and Alzheimer's disease.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh-hant
name
DSCR1/RCAN1 regulates vesicle ...... drome and Alzheimer's disease.
@en
DSCR1/RCAN1 regulates vesicle ...... drome and Alzheimer's disease.
@nl
type
label
DSCR1/RCAN1 regulates vesicle ...... drome and Alzheimer's disease.
@en
DSCR1/RCAN1 regulates vesicle ...... drome and Alzheimer's disease.
@nl
prefLabel
DSCR1/RCAN1 regulates vesicle ...... drome and Alzheimer's disease.
@en
DSCR1/RCAN1 regulates vesicle ...... drome and Alzheimer's disease.
@nl
P2093
P356
P1476
DSCR1/RCAN1 regulates vesicle ...... drome and Alzheimer's disease.
@en
P2093
Damien J Keating
Daphne Dubach
Katherine Martin
Laureane Mittaz
Mark P Zanin
Melanie A Pritchard
Sílvia Porta
Yu-Feng Zhao
P304
P356
10.1093/HMG/DDM374
P577
2008-01-07T00:00:00Z