Specific targeting of tau oligomers in Htau mice prevents cognitive impairment and tau toxicity following injection with brain-derived tau oligomeric seeds.
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NMR Meets Tau: Insights into Its Function and PathologyRescue from tau-induced neuronal dysfunction produces insoluble tau oligomersReducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathiesTau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo.Humanized monoclonal antibody armanezumab specific to N-terminus of pathological tau: characterization and therapeutic potencyCerebral Microvascular Accumulation of Tau Oligomers in Alzheimer's Disease and Related Tauopathies.Oligomeric tau-targeted immunotherapy in Tg4510 mice.Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L miceEpitope analysis following active immunization with tau proteins reveals immunogens implicated in tau pathogenesis.Characterization of tau oligomeric seeds in progressive supranuclear palsy.Antibody-derived in vivo imaging of tau pathology.PE859, a novel tau aggregation inhibitor, reduces aggregated tau and prevents onset and progression of neural dysfunction in vivo.Tau monoclonal antibody generation based on humanized yeast models: impact on Tau oligomerization and diagnosticsIsolation and characterization of antibody fragments selective for toxic oligomeric tauTau assembly: the dominant role of PHF6 (VQIVYK) in microtubule binding region repeat R3.Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice.Future Therapeutics in Alzheimer's Disease: Development Status of BACE Inhibitors.Rodent models for Alzheimer's disease drug discovery.Tau-Directed Immunotherapy: A Promising Strategy for Treating Alzheimer's Disease and Other Tauopathies.Characterization of Early Pathological Tau Conformations and Phosphorylation in Chronic Traumatic Encephalopathy.Therapy and clinical trials in frontotemporal dementia: past, present, and future.Subcutaneous liraglutide ameliorates methylglyoxal-induced Alzheimer-like tau pathology and cognitive impairment by modulating tau hyperphosphorylation and glycogen synthase kinase-3βTau Oligomers: Cytotoxicity, Propagation, and Mitochondrial Damage.Invited review: Drug development for tauopathies.The interrelationship of proteasome impairment and oligomeric intermediates in neurodegeneration.Potential mechanisms and implications for the formation of tau oligomeric strains.Extracellular Tau Oligomers Induce Invasion of Endogenous Tau into the Somatodendritic Compartment and Axonal Transport Dysfunction.Internalization of tau antibody and pathological tau protein detected with a flow cytometry multiplexing approachTau Oligomers Associate with Inflammation in the Brain and Retina of Tauopathy Mice and in Neurodegenerative Diseases.NPT088 reduces both amyloid-β and tau pathologies in transgenic miceExtracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory.Analysis of isoform-specific tau aggregates suggests a common toxic mechanism involving similar pathological conformations and axonal transport inhibition.Emerging Diagnostic and Therapeutic Strategies for Tauopathies.Tau Oligomers as Pathogenic Seeds: Preparation and Propagation In Vitro and In Vivo.What is the evidence that tau pathology spreads through prion-like propagation?Vaccination strategies in tauopathies and synucleinopathies.Tau Oligomers Derived from Traumatic Brain Injury Cause Cognitive Impairment and Accelerate Onset of Pathology in Htau Mice.Prophylactic Active Tau Immunization Leads to Sustained Reduction in Both Tau and Amyloid-β Pathologies in 3xTg Mice.Prospects for strain-specific immunotherapy in Alzheimer's disease and tauopathies.Tau oligomers mediate α-synuclein toxicity and can be targeted by immunotherapy.
P2860
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P2860
Specific targeting of tau oligomers in Htau mice prevents cognitive impairment and tau toxicity following injection with brain-derived tau oligomeric seeds.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年学术文章
@wuu
2014年学术文章
@zh
2014年学术文章
@zh-cn
2014年学术文章
@zh-hans
2014年学术文章
@zh-my
2014年学术文章
@zh-sg
2014年學術文章
@yue
2014年學術文章
@zh-hant
name
Specific targeting of tau olig ...... -derived tau oligomeric seeds.
@en
Specific targeting of tau olig ...... -derived tau oligomeric seeds.
@nl
type
label
Specific targeting of tau olig ...... -derived tau oligomeric seeds.
@en
Specific targeting of tau olig ...... -derived tau oligomeric seeds.
@nl
prefLabel
Specific targeting of tau olig ...... -derived tau oligomeric seeds.
@en
Specific targeting of tau olig ...... -derived tau oligomeric seeds.
@nl
P2093
P356
P1476
Specific targeting of tau olig ...... -derived tau oligomeric seeds.
@en
P2093
Cristian A Lasagna-Reeves
Julia E Gerson
Marcos J Guerrero-Muñoz
Rakez Kayed
Urmi Sengupta
P304
P356
10.3233/JAD-132477
P478
40 Suppl 1
P577
2014-01-01T00:00:00Z