Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus.
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Evidence for the direct involvement of {beta}TrCP in Gli3 protein processingDual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog signaling pathwayThe negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteinsGli proteins and the control of spinal-cord patterningA genetic screen in Drosophila for identifying novel components of the hedgehog signaling pathway.Suppressor of fused regulates Gli activity through a dual binding mechanismGSK-3: tricks of the trade for a multi-tasking kinaseDorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activityDecoding the phosphorylation code in Hedgehog signal transductionThe Hedgehog signalling pathway in bone formationDrosophila Smoothened phosphorylation sites essential for Hedgehog signal transductionSonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradationPhosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse developmentLoss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalusExtensive phosphorylation of Smoothened in Hedgehog pathway activationN-glycosylation enhances presentation of a MHC class I-restricted epitope from tyrosinaseRegulation of protein stability by GSK3 mediated phosphorylation.Control of neuronal ion channel function by glycogen synthase kinase-3: new prospective for an old kinase.GSK-3: Functional Insights from Cell Biology and Animal Models.Hedgehog signaling downregulates suppressor of fused through the HIB/SPOP-Crn axis in Drosophila.Capping Enzyme mRNA-cap/RNGTT Regulates Hedgehog Pathway Activity by Antagonizing Protein Kinase AInhibition of the nuclear import of cubitus interruptus by roadkill in the presence of strong hedgehog signal.Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors.Mechanism and evolution of cytosolic Hedgehog signal transductionFunctional studies of shaggy/glycogen synthase kinase 3 phosphorylation sites in Drosophila melanogaster.Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail.Disruption of Meox or Gli activity ablates skeletal myogenesis in P19 cells.Regulation of Hedgehog signaling: a complex story.Su(fu) switches Rdx functions to fine-tune hedgehog signaling in the Drosophila wing disk.Hedgehog-regulated atypical PKC promotes phosphorylation and activation of Smoothened and Cubitus interruptus in Drosophila.Priming-dependent phosphorylation and regulation of the tumor suppressor pVHL by glycogen synthase kinase 3.Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling.The role of kinases in the Hedgehog signalling pathway.What Are the bona fide GSK3 Substrates?CSN-mediated deneddylation differentially modulates Ci(155) proteolysis to promote Hedgehog signalling responsesThe contributions of protein kinase A and smoothened phosphorylation to hedgehog signal transduction in Drosophila melanogaster.Drosophila homeodomain-interacting protein kinase inhibits the Skp1-Cul1-F-box E3 ligase complex to dually promote Wingless and Hedgehog signaling.Hyperplastic discs differentially regulates the transcriptional outputs of hedgehog signalingThe Hedgehog signaling pathway--implications for drug targets in cancer and neurodegenerative disorders.Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation.
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P2860
Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus.
@en
Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus.
@nl
type
label
Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus.
@en
Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus.
@nl
prefLabel
Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus.
@en
Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus.
@nl
P2093
P2860
P356
P1433
P1476
Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus.
@en
P2093
Gelin Wang
Jianhang Jia
Jiong Tang
Kazuhito Amanai
P2860
P2888
P304
P356
10.1038/NATURE733
P407
P577
2002-03-24T00:00:00Z
P6179
1024555289