Identification of a tetrameric hedgehog signaling complex.
about
Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog signaling pathwayMice deficient in the fused homolog do not exhibit phenotypes indicative of perturbed hedgehog signaling during embryonic developmentThe negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteinsSuppressor of fused regulates Gli activity through a dual binding mechanismHedgehog signal transduction proteins: contacts of the Fused kinase and Ci transcription factor with the kinesin-related protein Costal2.Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition.Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conservedInhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalusIdentification of a functional interaction between the transmembrane protein Smoothened and the kinesin-related protein Costal2.Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5.Costal2 functions as a kinesin-like protein in the hedgehog signal transduction pathwayHedgehog signaling downregulates suppressor of fused through the HIB/SPOP-Crn axis in Drosophila.Inhibition of the nuclear import of cubitus interruptus by roadkill in the presence of strong hedgehog signal.Mechanism and evolution of cytosolic Hedgehog signal transductionSmoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail.The carboxyl-terminal domain of the protein kinase fused can function as a dominant inhibitor of hedgehog signaling.Regulation of Hedgehog signaling: a complex story.Distinct posttranscriptional mechanisms regulate the activity of the Zn finger transcription factor lame duck during Drosophila myogenesis.Su(fu) switches Rdx functions to fine-tune hedgehog signaling in the Drosophila wing disk.A novel autosomal recessive GJA1 missense mutation linked to Craniometaphyseal dysplasiaThe extracellular loops of Smoothened play a regulatory role in control of Hedgehog pathway activation.A Comparison of Ci/Gli Activity as Regulated by Sufu in Drosophila and Mammalian Hedgehog ResponseFused-Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and cell-surface accumulationExtramacrochaetae imposes order on the Drosophila eye by refining the activity of the Hedgehog signaling gradientThe Kinesin-related protein Costal2 associates with membranes in a Hedgehog-sensitive, Smoothened-independent manner.Smoothened regulates activator and repressor functions of Hedgehog signaling via two distinct mechanisms.mars and tousled-like kinase act in parallel to ensure chromosome fidelity in Drosophila.G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling.A quantification of pathway components supports a novel model of Hedgehog signal transductionSuppressor of fused impedes Ci/Gli nuclear import by opposing Trn/Kapβ2 in Hedgehog signaling.An intramolecular association between two domains of the protein kinase Fused is necessary for Hedgehog signaling.Non-cell-autonomous signaling by Shh in tumors: challenges and opportunities for therapeutic targets.The sonic hedgehog-GLI1 signaling pathway in brain tumor development.The Hedgehog signal transduction network.Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction.Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus.Hedgehog-stimulated phosphorylation of the kinesin-related protein Costal2 is mediated by the serine/threonine kinase fused.The fused protein kinase regulates Hedgehog-stimulated transcriptional activation in Drosophila Schneider 2 cells.Costal 2 interactions with Cubitus interruptus (Ci) underlying Hedgehog-regulated Ci processing
P2860
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P2860
Identification of a tetrameric hedgehog signaling complex.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
@zh-hant
name
Identification of a tetrameric hedgehog signaling complex.
@en
Identification of a tetrameric hedgehog signaling complex.
@nl
type
label
Identification of a tetrameric hedgehog signaling complex.
@en
Identification of a tetrameric hedgehog signaling complex.
@nl
prefLabel
Identification of a tetrameric hedgehog signaling complex.
@en
Identification of a tetrameric hedgehog signaling complex.
@nl
P2093
P2860
P356
P1476
Identification of a tetrameric hedgehog signaling complex.
@en
P2093
D J Robbins
G Elangovan
J E Vallance
J Sosinski
M A Stegman
P2860
P304
21809-21812
P356
10.1074/JBC.C000043200
P407
P577
2000-07-01T00:00:00Z