G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling.
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The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteinsNon-Canonical Hh Signaling in Cancer-Current Understanding and Future DirectionsIns and outs of GPCR signaling in primary ciliaAberrant activation of the hedgehog signaling pathway in malignant hematological neoplasmsPrimary cilium and sonic hedgehog signaling during neural tube patterning: role of GPCRs and second messengersDecoding the phosphorylation code in Hedgehog signal transductionHedgehog signaling acts with the temporal cascade to promote neuroblast cell cycle exitStructural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signallingCilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conservedSmoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium.RNA-seq reveals determinants of sensitivity to chemotherapy drugs in esophageal carcinoma cells.Competing activities of heterotrimeric G proteins in Drosophila wing maturation.Mys protein regulates protein kinase A activity by interacting with regulatory type Ialpha subunit during vertebrate developmentCapping Enzyme mRNA-cap/RNGTT Regulates Hedgehog Pathway Activity by Antagonizing Protein Kinase ARequirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception.Hedgehog signaling in the normal and neoplastic mammary gland.Mechanism and evolution of cytosolic Hedgehog signal transductionUSP8 promotes smoothened signaling by preventing its ubiquitination and changing its subcellular localizationHedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila.Activation of the Hh pathway in periosteum-derived mesenchymal stem cells induces bone formation in vivo: implication for postnatal bone repair.Smoothened Regulation: A Tale of Two Signals.Antagonistic interactions of hedgehog, Bmp and retinoic acid signals control zebrafish endocrine pancreas development.Ciliopathies: an expanding disease spectrum.Sonic hedgehog signaling is decoded by calcium spike activity in the developing spinal cord.Regulator of G-protein signaling - 5 (RGS5) is a novel repressor of hedgehog signaling.Gas1 is a receptor for sonic hedgehog to repel enteric axons.Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process.Heterotrimeric Gi proteins link Hedgehog signaling to activation of Rho small GTPases to promote fibroblast migration.Clinical implications of hedgehog signaling pathway inhibitorsRegulation of smoothened by Drosophila G-protein-coupled receptor kinases.The alpha subunit of the G protein G13 regulates activity of one or more Gli transcription factors independently of smoothened.Arrestin development: emerging roles for beta-arrestins in developmental signaling pathwaysG protein-coupled receptor kinases: more than just kinases and not only for GPCRsThe extracellular loops of Smoothened play a regulatory role in control of Hedgehog pathway activation.Functional Divergence in the Role of N-Linked Glycosylation in Smoothened SignalingSonic hedgehog maintains cellular and neurochemical homeostasis in the adult nigrostriatal circuitHedgehog induces formation of PKA-Smoothened complexes to promote Smoothened phosphorylation and pathway activation.The Hedgehog pathway: role in cell differentiation, polarity and proliferationA Smoothened receptor agonist is neuroprotective and promotes regeneration after ischemic brain injurySequential phosphorylation of smoothened transduces graded hedgehog signaling.
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G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on December 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling.
@en
G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling.
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type
label
G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling.
@en
G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling.
@nl
prefLabel
G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling.
@en
G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling.
@nl
P2093
P2860
P356
P1433
P1476
G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling.
@en
P2093
David J Robbins
Dennis Liang Fei
Neal S Schilling
Stacey K Ogden
Yashi F Ahmed
P2860
P2888
P304
P356
10.1038/NATURE07459
P407
P577
2008-12-01T00:00:00Z
P5875
P6179
1045424757