Sqstm1 knock-down causes a locomotor phenotype ameliorated by rapamycin in a zebrafish model of ALS/FTLD.

Sqstm1 knock-down causes a locomotor phenotype ameliorated by rapamycin in a zebrafish model of ALS/FTLD.

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http://www.wikidata.org/entity/Q47073358
The circadian clock regulates autophagy directly through the nuclear hormone receptor Nr1d1/Rev-erbα and indirectly via Cebpb/(C/ebpβ) in zebrafish.Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell deathAmyotrophic lateral sclerosis patient iPSC-derived astrocytes impair autophagy via non-cell autonomous mechanisms.Defective recognition of LC3B by mutant SQSTM1/p62 implicates impairment of autophagy as a pathogenic mechanism in ALS-FTLD.Iron and Neurodegeneration: Is Ferritinophagy the Link?Studying Autophagy in Zebrafish.Motoneuron Disease: Basic Science.Multifaceted role of SMCR8 as autophagy regulator.Autophagy Dysregulation in ALS: When Protein Aggregates Get Out of Hand.Is amyotrophic lateral sclerosis/frontotemporal dementia an autophagy disease?Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy.Dysregulated molecular pathways in amyotrophic lateral sclerosis-frontotemporal dementia spectrum disorder.Causative Genes in Amyotrophic Lateral Sclerosis and Protein Degradation Pathways: a Link to Neurodegeneration.Modeling Environmentally-Induced Motor Neuron Degeneration in Zebrafish.Autophagy in Age-Associated Neurodegeneration.Rapamycin treatment for amyotrophic lateral sclerosis: Protocol for a phase II randomized, double-blind, placebo-controlled, multicenter, clinical trial (RAP-ALS trial).
P2860

Sqstm1 knock-down causes a locomotor phenotype ameliorated by rapamycin in a zebrafish model of ALS/FTLD.

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http://www.wikidata.org/entity/Q47073358
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Sqstm1 knock-down causes a loc ...... a zebrafish model of ALS/FTLD.
@en
Sqstm1 knock-down causes a loc ...... a zebrafish model of ALS/FTLD.
@nl
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label
Sqstm1 knock-down causes a loc ...... a zebrafish model of ALS/FTLD.
@en
Sqstm1 knock-down causes a loc ...... a zebrafish model of ALS/FTLD.
@nl
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Sqstm1 knock-down causes a loc ...... a zebrafish model of ALS/FTLD.
@en
Sqstm1 knock-down causes a loc ...... a zebrafish model of ALS/FTLD.
@nl
P1433
P1476
P2093
P2860
P304
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P433
P478
P50
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P1433
P1476
Sqstm1 knock-down causes a loc ...... a zebrafish model of ALS/FTLD.
@en
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P698
P921