Investigating the role of the little finger domain of Y-family DNA polymerases in low fidelity synthesis and translesion replication.
about
Separate roles of structured and unstructured regions of Y-family DNA polymerasesEukaryotic translesion polymerases and their roles and regulation in DNA damage toleranceNovel thermostable Y-family polymerases: applications for the PCR amplification of damaged or ancient DNAsStructural basis of error-prone replication and stalling at a thymine base by human DNA polymerase ιStructural and Functional Elucidation of the Mechanism Promoting Error-prone Synthesis by Human DNA Polymerase Opposite the 7,8-Dihydro-8-oxo-2'-deoxyguanosine AdductY-Family Polymerase Conformation Is a Major Determinant of Fidelity and Translesion SpecificityThree Residues of the Interdomain Linker Determine the Conformation and Single-base Deletion Fidelity of Y-family Translesion PolymerasesThe PAD region in the mycobacterial DinB homologue MsPolIV exhibits positional heterogeneityKinetics, Structure, and Mechanism of 8-Oxo-7,8-dihydro-2'-deoxyguanosine Bypass by Human DNA PolymeraseA Genetic Selection for dinB Mutants Reveals an Interaction between DNA Polymerase IV and the Replicative Polymerase That Is Required for Translesion SynthesisMutagenic nucleotide incorporation and hindered translocation by a food carcinogen C8-dG adduct in Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4): modeling and dynamics studies.DNA binding strength increases the processivity and activity of a Y-Family DNA polymeraseFidelity of Dpo4: effect of metal ions, nucleotide selection and pyrophosphorolysis.UmuD(2) inhibits a non-covalent step during DinB-mediated template slippage on homopolymeric nucleotide runs.Pre-Steady-State Kinetic Analysis of Truncated and Full-Length Saccharomyces cerevisiae DNA Polymerase Eta.Visualizing sequence-governed nucleotide selectivities and mutagenic consequences through a replicative cycle: processing of a bulky carcinogen N2-dG lesion in a Y-family DNA polymerase.Translesion DNA polymerasesMolecular dissection of the domain architecture and catalytic activities of human PrimPol.Translesion DNA Synthesis.Quantitative analysis of the efficiency and mutagenic spectra of abasic lesion bypass catalyzed by human Y-family DNA polymerases.A high-throughput screening method to reengineer DNA polymerases for random mutagenesis.Conformational dynamics of a Y-family DNA polymerase during substrate binding and catalysis as revealed by interdomain Förster resonance energy transfer.A nucleotide binding rectification Brownian ratchet model for translocation of Y-family DNA polymerasesUV-B radiation induces epithelial tumors in mice lacking DNA polymerase eta and mesenchymal tumors in mice deficient for DNA polymerase iotaDynamic conformational change regulates the protein-DNA recognition: an investigation on binding of a Y-family polymerase to its target DNA.Mechanism of template-independent nucleotide incorporation catalyzed by a template-dependent DNA polymeraseNoncognate DNA damage prevents the formation of the active conformation of the Y-family DNA polymerases DinB and DNA polymerase κDNA lesion alters global conformational dynamics of Y-family DNA polymerase during catalysisWhat a difference a decade makes: insights into translesion DNA synthesis.Portraits of a Y-family DNA polymerase.Lesion-Induced Mutation in the Hyperthermophilic Archaeon Sulfolobus acidocaldarius and Its Avoidance by the Y-Family DNA Polymerase Dbh.Roles of translesion synthesis DNA polymerases in the potent mutagenicity of tobacco-specific nitrosamine-derived O2-alkylthymidines in human cells.Site-directed Mutagenesis (Y52E) of POLH Affects Its Ability to Bypass Ultraviolet-induced DNA Lesions in HaCaT CellsDifferential temperature-dependent multimeric assemblies of replication and repair polymerases on DNA increase processivity.Multiple functions of DNA polymerases.Y-family DNA polymerases and their role in tolerance of cellular DNA damage.Human polymerase kappa uses a template-slippage deletion mechanism, but can realign the slipped strands to favour base substitution mutations over deletionsThe rate and character of spontaneous mutation in Thermus thermophilus.Controlling mutation: intervening in evolution as a therapeutic strategy.DNA adduct structure-function relationships: comparing solution with polymerase structures.
P2860
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P2860
Investigating the role of the little finger domain of Y-family DNA polymerases in low fidelity synthesis and translesion replication.
description
2004 nî lūn-bûn
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2004年の論文
@ja
2004年学术文章
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2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
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name
Investigating the role of the ...... s and translesion replication.
@en
Investigating the role of the ...... s and translesion replication.
@nl
type
label
Investigating the role of the ...... s and translesion replication.
@en
Investigating the role of the ...... s and translesion replication.
@nl
prefLabel
Investigating the role of the ...... s and translesion replication.
@en
Investigating the role of the ...... s and translesion replication.
@nl
P2093
P2860
P356
P1476
Investigating the role of the ...... is and translesion replication
@en
P2093
Brian S Plosky
François Boudsocq
Robert J Kokoska
Roger Woodgate
P2860
P304
32932-32940
P356
10.1074/JBC.M405249200
P407
P577
2004-05-21T00:00:00Z