Characteristic interactions with phosphatidylinositol 4,5-bisphosphate determine regulation of kir channels by diverse modulators. - Wikidata - wikimedia - TriplyDB

Characteristic interactions with phosphatidylinositol 4,5-bisphosphate determine regulation of kir channels by diverse modulators.

Characteristic interactions with phosphatidylinositol 4,5-bisphosphate determine regulation of kir channels by diverse modulators.

http://www.wikidata.org/entity/Q47448312

about

How highly charged anionic lipids bind and regulate ion channels Crystal structure of a Kir3.1-prokaryotic Kir channel chimera Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2 Sequential phosphorylation mediates receptor- and kinase-induced inhibition of TREK-1 background potassium channels Interaction of the Ca2+-sensing receptor with the inwardly rectifying potassium channels Kir4.1 and Kir4.2 results in inhibition of channel function The function and molecular identity of inward rectifier channels in vestibular hair cells of the mouse inner ear Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain Lipid agonism: The PIP2 paradigm of ligand-gated ion channels Molecular determinants of PI(4,5)P2 and PI(3,4,5)P3 regulation of the epithelial Na+ channel Chloroquine terminates stretch-induced atrial fibrillation more effectively than flecainide in the sheep heart Depolarization increases phosphatidylinositol (PI) 4,5-bisphosphate level and KCNQ currents through PI 4-kinase mechanisms Phosphatidylinositol-4,5-bisphosphate (PIP(2)) stabilizes the open pore conformation of the Kv11.1 (hERG) channel Decoding the signaling of a GPCR heteromeric complex reveals a unifying mechanism of action of antipsychotic drugs.Hypertension resistance polymorphisms in ROMK (Kir1.1) alter channel function by different mechanisms.Interplay Between Lipid Modulators of Kir2 Channels: Cholesterol and PIP2.N-terminal transmembrane domain of SUR1 controls gating of Kir6.2 by modulating channel sensitivity to PIP2 Muscarinic depolarization of layer II neurons of the parasubiculum.The role of G proteins in assembly and function of Kir3 inwardly rectifying potassium channels.A long QT mutation substitutes cholesterol for phosphatidylinositol-4,5-bisphosphate in KCNQ1 channel regulation.Phosphoinositides regulate ion channels.Membrane depolarization increases membrane PtdIns(4,5)P2 levels through mechanisms involving PKC βII and PI4 kinase.G protein-coupled receptor signaling to Kir channels in Xenopus oocytes.Genetic defects in the hotspot of inwardly rectifying K(+) (Kir) channels and their metabolic consequences: a review Transient receptor potential melastatin 3 is a phosphoinositide-dependent ion channel Phosphoinositide control of membrane protein function: a frontier led by studies on ion channels.Mutations in Nature Conferred a High Affinity Phosphatidylinositol 4,5-Bisphosphate-binding Site in Vertebrate Inwardly Rectifying Potassium Channels Molecular overlap in the regulation of SK channels by small molecules and phosphoinositides Regulation of voltage-gated potassium channels by PI(4,5)P2 Electrostatic interaction of internal Mg2+ with membrane PIP2 Seen with KCNQ K+ channels.Inhibition of inwardly rectifying Kir2.x channels by the novel anti-cancer agent gambogic acid depends on both pore block and PIP2 interference.Distant cytosolic residues mediate a two-way molecular switch that controls the modulation of inwardly rectifying potassium (Kir) channels by cholesterol and phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)).Phosphoinositide interacting regulator of TRP (Pirt) enhances TRPM8 channel activity in vitro via increasing channel conductance.Ligand-dependent linkage of the ATP site to inhibition gate closure in the KATP channel Supervised membrane swimming: small G-protein lifeguards regulate PIPK signalling and monitor intracellular PtdIns(4,5)P2 pools.Diverse Kir modulators act in close proximity to residues implicated in phosphoinositide binding.Distinctive changes in plasma membrane phosphoinositides underlie differential regulation of TRPV1 in nociceptive neurons.Inhibition of ROMK channels by low extracellular K+ and oxidative stress.PKC activation and PIP(2) depletion underlie biphasic regulation of IKs by Gq-coupled receptors.Identification of a C-terminus domain critical for the sensitivity of Kir2.1 to cholesterol PIP2 is a necessary cofactor for ion channel function: how and why?

P2860

Q24656180-2522789B-FEE8-4F4B-AACE-A792F35718A3 Q27647344-DEAB42BE-3145-4AD5-8714-AABAAD88ABBC Q28256776-F160F5CE-F5DA-4512-8626-6A04899C5EF9 Q28260733-4F16D555-D7F7-489E-B73A-99B934D1C2CD Q28275263-A1B71E6D-7CE8-4050-9ADD-868C0A97D8B5 Q28728048-015600FE-C9F8-43AC-94F9-F54B67BC6AE4 Q28757606-058B2458-0F63-4FB1-9319-36BED4990B30 Q30371227-B25A14AE-D367-430F-A614-97FE1C46C946 Q30496572-4DD8D75B-0550-4C45-A883-39B97F7AC0F6 Q30517295-2744C64F-E36A-4CE5-BB35-4C7A28D0B3F4 Q33744493-8EC10991-ECFA-4F6E-9DF6-C3551C8C1413 Q34062260-D70E4089-8E2D-4769-9254-40EB949B479C Q34236107-4773B01E-B2A2-4FA0-8546-A60E1E9C1780 Q34426364-7194EB41-229F-4525-8CEE-11EA532DDEEB Q34514622-5952DFCB-1F61-4A14-B9EC-5BD1A59DE687 Q34618893-EF93BF16-4F54-41D4-8359-12A4FEA49B57 Q34631956-A9E46D87-BC24-4862-BE2E-0222D980ABEF Q34638080-2C579AB4-D7E5-4B8C-B8B5-963E9B3DF0AD Q35134951-FA21A65D-CE43-4939-8604-669971156AEE Q35192402-1F77D549-B449-492D-B5AE-E21479385A54 Q35562837-793D1FDA-8E1C-469A-B453-2F08E8444303 Q35589714-A6501476-1903-4D01-AFBB-70C2EEF2146E Q35661470-0125AB5A-0F84-41CE-A591-DD3A64B4936A Q35795770-878ED0DA-F81E-48FA-914A-0A1620A41CB7 Q35799988-D920C6D4-9A9A-4A5D-8CCD-4914F3752CF0 Q35860472-DF1B58CF-B9ED-44E8-975B-574A34DDAD92 Q36040703-E14ED43F-EEEA-4ABD-B9E8-29E9C9BD20C0 Q36130312-A7A32EE1-775B-4087-B696-C2EA1988D9BD Q36296073-B1B323C6-B92A-4B7F-AA4C-74B4AF3764EE Q36331012-A9BC4CE7-F2AC-42A9-AE3A-2B52B370E19D Q36418792-C814205D-06ED-41FF-8CDF-9755FC9F5C75 Q36490547-D7E73E05-2E3D-4E89-8D21-A2186B56193F Q36493543-CF50FA1C-DC15-4E7D-8104-593C4DD3BC5F Q36542078-B830FE91-E339-4CE7-855E-118DC246D267 Q36818139-CF5CA2FD-C2E4-46E4-B6B4-8055A163AF14 Q37048101-A50C06FC-CC2F-40EC-9913-904F357929FE Q37051431-780DDE1B-1FF6-4097-A720-2CCE9AED9D1A Q37157529-19A00522-C568-4AAE-BCA4-268BCC52D9BC Q37194773-43F5E50C-3195-40A9-A382-FBB0C3684E48 Q37197976-1FA8BE25-8C2C-47A2-B913-CE22D66D8FCD

P2860

Characteristic interactions with phosphatidylinositol 4,5-bisphosphate determine regulation of kir channels by diverse modulators.

http://www.wikidata.org/entity/Q47448312

description

2004 nî lūn-bûn

@nan

2004年の論文

@ja

2004年学术文章

@wuu

2004年学术文章

@zh

2004年学术文章

@zh-cn

2004年学术文章

@zh-hans

2004年学术文章

@zh-my

2004年学术文章

@zh-sg

2004年學術文章

@yue

2004年學術文章

@zh-hant

name

Characteristic interactions wi ...... hannels by diverse modulators.

@en

Characteristic interactions wi ...... hannels by diverse modulators.

@nl

type

label

Characteristic interactions wi ...... hannels by diverse modulators.

@en

Characteristic interactions wi ...... hannels by diverse modulators.

@nl

prefLabel

Characteristic interactions wi ...... hannels by diverse modulators.

@en

Characteristic interactions wi ...... hannels by diverse modulators.

@nl

P1433

Q47448312-9C4726C9-E00A-4CD4-856F-9BEFB84D24F6

P1476

Q47448312-C64509D1-57F4-4560-95B7-49690F4E24DC

P2093

Q47448312-54C97E7C-6DA2-44CE-8EE6-470CF9156775

Q47448312-6E36A166-EFD8-4C4D-85AB-973DA9F68CD8

Q47448312-91A5443D-402D-4256-9715-D61A33644475

Q47448312-AC220C2A-56C6-4026-A52D-BB2EE945B13A

Q47448312-D51D0BA4-F97A-408C-AEA0-0A40B56D5B7B

Q47448312-F2B2414A-737F-4CF8-9D32-19E8B2E44E83

P2860

Q47448312-08A5E304-960C-4A39-9C19-F5E7F4400A41

Q47448312-200CA605-555E-46D0-B4B1-4A17D48D2C8B

Q47448312-2843FF3F-1394-40AA-BD6B-52E72B2ACC34

Q47448312-2C910466-A7C7-4A1B-8263-13D5F94A1140

Q47448312-3600CF40-03A0-438B-A38C-C5E382F04314

Q47448312-3655D751-4813-4CBA-A2BD-3A02456D1F84

Q47448312-3C090CE6-7902-4DC4-B04A-9BD040DFC963

Q47448312-3D4EF6AE-8ABE-4482-93FB-464341DBB987

Q47448312-3D690DB3-AEAF-43E9-AFD2-7D69276E1925

Q47448312-465125B0-7324-4572-8145-BD10516DC40A

P304

Q47448312-EFABD364-AFEA-4EB1-A9D8-ECCC5A8F4C44

P31

Q47448312-A16B8A7B-3E3C-424D-A98E-C55337B3E6C5

P356

Q47448312-7B92B496-2C1A-4859-9D88-708271E45EE9

P407

Q47448312-EB9AFDEE-8F1A-4D9F-BEE8-936A18DDCC3B

P433

Q47448312-777B6D05-52E0-49ED-B111-2589313C39BB

P478

Q47448312-67C04B4C-B6F4-4578-B9B8-5A56DAD52DBC

P577

Q47448312-308EBE08-516C-4046-BEF7-E8BA413EC8CB

P698

Q47448312-187722B9-4F2F-490F-AA03-A817EC43F53F

P356

P1433

Journal of Biological Chemistry

P1476

Characteristic interactions wi ...... hannels by diverse modulators.

@en

P2093

Coeli Lopes

http://www.w3.org/2001/XMLSchema#string

Diomedes E Logothetis

http://www.w3.org/2001/XMLSchema#string

Hailin Zhang

http://www.w3.org/2001/XMLSchema#string

Tibor Rohacs

http://www.w3.org/2001/XMLSchema#string

Tooraj Mirshahi

http://www.w3.org/2001/XMLSchema#string

Xiaona Du

http://www.w3.org/2001/XMLSchema#string

P2860

Alterations in conserved Kir channel-PIP2 interactions underlie channelopathies

Structural basis of inward rectification: cytoplasmic pore of the G protein-gated inward rectifier GIRK1 at 1.8 A resolution

Suppression of Kir2.3 activity by protein kinase C phosphorylation of the channel protein at threonine 53

Transforming growth factor-beta 1 regulates Kir2.3 inward rectifier K+ channels via phospholipase C and protein kinase C-delta in reactive astrocytes from adult rat brain

Electrophysiology of the pancreatic beta-cell

Glucose induces closure of single potassium channels in isolated rat pancreatic beta-cells

Regulation of a G protein-gated inwardly rectifying K+ channel by a Ca(2+)-independent protein kinase C

Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs

Depletion of phosphatidylinositol 4,5-bisphosphate by activation of phospholipase C-coupled receptors causes slow inhibition but not desensitization of G protein-gated inward rectifier K+ current in atrial myocytes.

Multiple PIP2 binding sites in Kir2.1 inwardly rectifying potassium channels.

P304

37271-37281

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1074/JBC.M403413200

http://www.w3.org/2001/XMLSchema#string

P407

P433

36

http://www.w3.org/2001/XMLSchema#string

P478

279

http://www.w3.org/2001/XMLSchema#string

P577

2004-05-20T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

15155739

http://www.w3.org/2001/XMLSchema#string