about
Treatment of co-infection with bancroftian filariasis and onchocerciasis: a safety and efficacy study of albendazole with ivermectin compared to treatment of single infection with bancroftian filariasisEvidence against Wolbachia symbiosis in Loa loaDiethylcarbamazine activity against Brugia malayi microfilariae is dependent on inducible nitric-oxide synthase and the cyclooxygenase pathwayST2 deficiency does not impair type 2 immune responses during chronic filarial infection but leads to an increased microfilaremia due to an impaired splenic microfilarial clearanceAnti-Wolbachia drug discovery and development: safe macrofilaricides for onchocerciasis and lymphatic filariasisDoxycycline reduces plasma VEGF-C/sVEGFR-3 and improves pathology in lymphatic filariasisImmunoepidemiological profiling of onchocerciasis patients reveals associations with microfilaria loads and ivermectin intake on both individual and community levelsShort-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis.Macrofilaricidal activity after doxycycline only treatment of Onchocerca volvulus in an area of Loa loa co-endemicity: a randomized controlled trial.Wolbachia bacteria of filarial nematodes.Anti-filarial activity of antibiotic therapy is due to extensive apoptosis after Wolbachia depletion from filarial nematodes.Endosymbiotic bacteria associated with nematodes, ticks and amoebae.The role of endosymbiotic Wolbachia bacteria in the pathogenesis of river blindness.Lipoprotein biosynthesis as a target for anti-Wolbachia treatment of filarial nematodes.Wolbachia lipoproteins: abundance, localisation and serology of Wolbachia peptidoglycan associated lipoprotein and the Type IV Secretion System component, VirB6 from Brugia malayi and Aedes albopictus.A murine macrofilaricide pre-clinical screening model for onchocerciasis and lymphatic filariasisMacrofilaricidal activity after doxycycline treatment of Wuchereria bancrofti: a double-blind, randomised placebo-controlled trial.Repurposing of approved drugs from the human pharmacopoeia to target Wolbachia endosymbionts of onchocerciasis and lymphatic filariasis.Wolbachia bacterial endosymbionts of filarial nematodes.Onchocerca parasites and Wolbachia endosymbionts: evaluation of a spectrum of antibiotic types for activity against Onchocerca gutturosa in vitro.Human filarial Wolbachia lipopeptide directly activates human neutrophils in vitroCulture and phenotypic characterization of a Wolbachia pipientis isolate.Extensively duplicated and transcriptionally active recent lateral gene transfer from a bacterial Wolbachia endosymbiont to its host filarial nematode Brugia malayi.Therapeutic efficacy and macrofilaricidal activity of doxycycline for the treatment of river blindnessDevelopment and validation of a high-throughput anti-Wolbachia whole-cell screen: a route to macrofilaricidal drugs against onchocerciasis and lymphatic filariasis.Ancient and novel small RNA pathways compensate for the loss of piRNAs in multiple independent nematode lineages.Autophagy regulates Wolbachia populations across diverse symbiotic associations.Doxycycline improves filarial lymphedema independent of active filarial infection: a randomized controlled trial.Tropomyosin implicated in host protective responses to microfilariae in onchocerciasis.Absence of Wolbachia endobacteria in the non-filariid nematodes Angiostrongylus cantonensis and A. costaricensisOnchocerciasis Control: Vision for the Future from a Ghanian perspective.Whole-genome sequencing of Trypanosoma brucei reveals introgression between subspecies that is associated with virulence.Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study.Wolbachia lipoprotein stimulates innate and adaptive immunity through Toll-like receptors 2 and 6 to induce disease manifestations of filariasis.Filarial infection influences mosquito behaviour and fecundity.Current practices in the management of lymphatic filariasis.Wolbachia-induced neutrophil activation in a mouse model of ocular onchocerciasis (river blindness).Absence of Wolbachia endobacteria in the human parasitic nematode Dracunculus medinensis and two related Dracunculus species infecting wildlife.Overcoming the challenges of drug discovery for neglected tropical diseases: the A·WOL experience.Severe reactions to filarial chemotherapy and release of Wolbachia endosymbionts into blood.
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P50
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