RAG proteins shepherd double-strand breaks to a specific pathway, suppressing error-prone repair, but RAG nicking initiates homologous recombination.
about
Altered hematopoiesis in mice lacking DNA polymerase mu is due to inefficient double-strand break repairActivation of an alternative, rec12 (spo11)-independent pathway of fission yeast meiotic recombination in the absence of a DNA flap endonucleaseAlternative induction of meiotic recombination from single-base lesions of DNA deaminasesThe ancient mariner sails again: transposition of the human Hsmar1 element by a reconstructed transposase and activities of the SETMAR protein on transposon endsTowards a new era in medicine: therapeutic genome editingLong-Range Regulation of V(D)J RecombinationNext-generation prognostic assessment for diffuse large B-cell lymphomaRepair of strand breaks by homologous recombinationRegulation of repair choice: Cdk1 suppresses recruitment of end joining factors at DNA breaks.The role of DNA double-strand breaks in spontaneous homologous recombination in S. cerevisiaeSnaps and mends: DNA breaks and chromosomal translocationsMutations in the NHEJ component XRCC4 cause primordial dwarfismSingle-strand recombination signal sequence nicks in vivo: evidence for a capture model of synapsisTargeted gene addition to a predetermined site in the human genome using a ZFN-based nicking enzymePARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathwaysTemporal regulation of Ig gene diversification revealed by single-cell imaging.Chromatin structure regulates gene conversion.In my end is my beginning: control of end resection and DSBR pathway 'choice' by cyclin-dependent kinases.Genetic evidence for single-strand lesions initiating Nbs1-dependent homologous recombination in diversification of Ig v in chicken B lymphocytes.RAG2's acidic hinge restricts repair-pathway choice and promotes genomic stability.Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination.Non-consensus heptamer sequences destabilize the RAG post-cleavage complex, making ends available to alternative DNA repair pathways.The in vivo pattern of binding of RAG1 and RAG2 to antigen receptor loci.Synapsis alters RAG-mediated nicking at Tcrb recombination signal sequences: implications for the “beyond 12/23” ruleDNA nicks promote efficient and safe targeted gene correction.Chromosomal aberrations induced by double strand DNA breaks.Regulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair.Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effectsPathway choice in DNA double strand break repair: observations of a balancing act.Mechanisms of double-strand break repair in somatic mammalian cells.Evolutionary diversity and potential recombinogenic role of integration targets of Non-LTR retrotransposons.Natural and engineered nicking endonucleases--from cleavage mechanism to engineering of strand-specificitySingle-strand nicks induce homologous recombination with less toxicity than double-strand breaks using an AAV vector template.A natural meiotic DNA break site in Schizosaccharomyces pombe is a hotspot of gene conversion, highly associated with crossing over.MuDR transposase increases the frequency of meiotic crossovers in the vicinity of a Mu insertion in the maize a1 geneAntigen-receptor genes of the agnathan lamprey are assembled by a process involving copy choice.Coupling of V(D)J recombination to the cell cycle suppresses genomic instability and lymphoid tumorigenesis.Base flipping in V(D)J recombination: insights into the mechanism of hairpin formation, the 12/23 rule, and the coordination of double-strand breaks
P2860
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P2860
RAG proteins shepherd double-strand breaks to a specific pathway, suppressing error-prone repair, but RAG nicking initiates homologous recombination.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
RAG proteins shepherd double-s ...... ates homologous recombination.
@en
RAG proteins shepherd double-s ...... ates homologous recombination.
@nl
type
label
RAG proteins shepherd double-s ...... ates homologous recombination.
@en
RAG proteins shepherd double-s ...... ates homologous recombination.
@nl
prefLabel
RAG proteins shepherd double-s ...... ates homologous recombination.
@en
RAG proteins shepherd double-s ...... ates homologous recombination.
@nl
P2093
P1433
P1476
RAG proteins shepherd double-s ...... ates homologous recombination.
@en
P2093
David B Roth
Gregory S Lee
Matthew B Neiditch
Sandra S Salus
P304
P356
10.1016/S0092-8674(04)00301-0
P407
P577
2004-04-01T00:00:00Z