Synthetic lethal metabolic targeting of cellular senescence in cancer therapy. - Wikidata - wikimedia - TriplyDB

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.

http://www.wikidata.org/entity/Q47778719

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"Inflammaging" as a Druggable Target: A Senescence-Associated Secretory Phenotype-Centered View of Type 2 Diabetes Olive Oil and the Hallmarks of Aging Cellular senescence in aging and age-related disease: from mechanisms to therapy Changes in Regenerative Capacity through Lifespan Macroautophagy and the oncogene-induced senescence Autophagy in malignant transformation and cancer progression Targeting mitochondrial metabolism by inhibiting autophagy in BRAF-driven cancers Disruptive chemicals, senescence and immortality Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition.Dynamic modelling of pathways to cellular senescence reveals strategies for targeted interventions Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H(+) symporters Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer Unique features of the transcriptional response to model aneuploidy in human cells Open access to high-content clonogenic analysis.Wnt5A promotes an adaptive, senescent-like stress response, while continuing to drive invasion in melanoma cells.NOTCH1 mediates a switch between two distinct secretomes during senescence.Glucose metabolism-targeted therapy and withaferin A are effective for epidermal growth factor receptor tyrosine kinase inhibitor-induced drug-tolerant persisters.From chromatogram to analyte to metabolite. How to pick horses for courses from the massive web-resources for mass spectral plant metabolomics Cellular senescence and protein degradation: breaking down cancer mTOR Signaling from Cellular Senescence to Organismal Aging The role of senescent cells in ageing.The Achilles' heel of senescent cells: from transcriptome to senolytic drugs.Myc-induced SUMOylation is a therapeutic vulnerability for B-cell lymphoma.Glucose substitution prolongs maintenance of energy homeostasis and lifespan of telomere dysfunctional mice Therapeutic strategies to inhibit MYC Hypoxia as a biomarker for radioresistant cancer stem cells.Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse.PERK silence inhibits glioma cell growth under low glucose stress by blockage of p-AKT and subsequent HK2's mitochondria translocation.Phenotype specific analyses reveal distinct regulatory mechanism for chronically activated p53 The role for autophagy in cancer.Silencing erythropoietin receptor on glioma cells reinforces efficacy of temozolomide and X-rays through senescence and mitotic catastrophe Overexpression of the novel senescence marker β-galactosidase (GLB1) in prostate cancer predicts reduced PSA recurrence Cell Autonomous and Non-Autonomous Effects of Senescent Cells in the Skin.Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity.The HSP90 Inhibitor Ganetespib Radiosensitizes Human Lung Adenocarcinoma Cells.Aneuploidy generates proteotoxic stress and DNA damage concurrently with p53-mediated post-mitotic apoptosis in SAC-impaired cells Cell intrinsic and extrinsic activators of the unfolded protein response in cancer: Mechanisms and targets for therapy Retinoblastoma protein promotes oxidative phosphorylation through upregulation of glycolytic genes in oncogene-induced senescent cells.Activation of p53 contributes to pseudolaric acid B-induced senescence in human lung cancer cells in vitro MacroH2A1 and ATM Play Opposing Roles in Paracrine Senescence and the Senescence-Associated Secretory Phenotype

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P2860

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.

http://www.wikidata.org/entity/Q47778719

description

2013 nî lūn-bûn

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2013年の論文

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年學術文章

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2013年學術文章

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name

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.

@en

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.

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type

label

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.

@en

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.

@nl

prefLabel

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.

@en

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.

@nl

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Synthetic lethal metabolic targeting of cellular senescence in cancer therapy

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Anne Gerhardt

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Bernd Dörken

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Bettina Purfürst

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Dido Lenze

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Gregor Beuster

http://www.w3.org/2001/XMLSchema#string

Jan Lisec

http://www.w3.org/2001/XMLSchema#string

Jan R Dörr

http://www.w3.org/2001/XMLSchema#string

Lothar Willmitzer

http://www.w3.org/2001/XMLSchema#string

Markus Gräler

http://www.w3.org/2001/XMLSchema#string

Maurice Reimann

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P2860

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

A large-scale RNAi screen in human cells identifies new components of the p53 pathway

Autophagy mediates the mitotic senescence transition

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

Reevaluation of the 22-1-1 antibody and its putative antigen, EBAG9/RCAS1, as a tumor marker.

Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network.

The concept of synthetic lethality in the context of anticancer therapy

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421-425

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10.1038/NATURE12437

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7467

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501

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Andreas K. Buck

Clemens A Schmitt

Christin Zasada

Katharina Schleicher

J Henry M Däbritz

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2013-08-14T00:00:00Z

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