WNK Signaling Inhibitors as Potential Antihypertensive Drugs.

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WNK Signaling Inhibitors as Potential Antihypertensive Drugs.

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2017 nî lūn-bûn

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2017年の論文

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年學術文章

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2017年學術文章

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2017年學術文章

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WNK Signaling Inhibitors as Potential Antihypertensive Drugs.

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WNK Signaling Inhibitors as Potential Antihypertensive Drugs.

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WNK Signaling Inhibitors as Potential Antihypertensive Drugs.

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WNK Signaling Inhibitors as Potential Antihypertensive Drugs.

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WNK Signaling Inhibitors as Potential Antihypertensive Drugs.

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WNK Signaling Inhibitors as Potential Antihypertensive Drugs.

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P1476

WNK Signaling Inhibitors as Potential Antihypertensive Drugs.

@en

P2093

Abdulrahman Elzwawi

http://www.w3.org/2001/XMLSchema#string

Hachemi Kadri

http://www.w3.org/2001/XMLSchema#string

Mubarak A AlAmri

http://www.w3.org/2001/XMLSchema#string

Shumail Mahmood

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P2860

MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters

Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension

Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4

Structural insights into the recognition of substrates and activators by the OSR1 kinase

Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1

Small-molecule WNK inhibition regulates cardiovascular and renal function

Structure of the OSR1 kinase, a hypertension drug target

P304

1677-1686

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P31

scholarly article

P356

10.1002/CMDC.201700425

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P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P50

Youcef Mehellou

Binar A Dhiani

P577

2017-09-07T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

28881465

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