Identification, characterization, and inhibition of Plasmodium falciparum beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ).
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The Hotdog fold: wrapping up a superfamily of thioesterases and dehydratasesStructural basis for catalytic and inhibitory mechanisms of beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ)Emodin targets the β-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: enzymatic inhibition assay with crystal structural and thermodynamic characterizationInsights into the substrate specificity of a thioesterase Rv0098 of mycobacterium tuberculosis through X-ray crystallographic and molecular dynamics studiesUsing modern tools to probe the structure-function relationship of fatty acid synthasesTranscriptional analysis of the pre-erythrocytic stages of the rodent malaria parasite, Plasmodium yoeliiStructure and function of Rv0130, a conserved hypothetical protein from Mycobacterium tuberculosisRNA-Seq transcriptomic analysis with Bag2D software identifies key pathways enhancing lipid yield in a high lipid-producing mutant of the non-model green alga Dunaliella tertiolectaSynthesis and biological evaluation of NAS-21 and NAS-91 analogues as potential inhibitors of the mycobacterial FAS-II dehydratase enzyme Rv0636.Mass spectrometry-based systems approach for identification of inhibitors of Plasmodium falciparum fatty acid synthaseTargeting the fatty acid biosynthesis enzyme, beta-ketoacyl-acyl carrier protein synthase III (PfKASIII), in the identification of novel antimalarial agents.Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysisTargeting the Lipid Metabolic Pathways for the Treatment of Malaria.Inhibitors of nonhousekeeping functions of the apicoplast defy delayed death in Plasmodium falciparumA Substrate Mimic Allows High-Throughput Assay of the FabA Protein and Consequently the Identification of a Novel Inhibitor of Pseudomonas aeruginosa FabA'FAS't inhibition of malaria.Make it or take it: fatty acid metabolism of apicomplexan parasitesInhibiting bacterial fatty acid synthesis.Antimycobacterial Activity and Mechanism of Action of NAS-91Celastrol inhibits Plasmodium falciparum enoyl-acyl carrier protein reductase.Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine.Lipid synthesis in protozoan parasites: a comparison between kinetoplastids and apicomplexansInhibitors of fatty acid synthesis in prokaryotes and eukaryotes as anti-infective, anticancer and anti-obesity drugs.Recent advances in inhibitors of bacterial fatty acid synthesis type II (FASII) system enzymes as potential antibacterial agents.From crystal to compound: structure-based antimalarial drug discovery.Fatty acid biosynthesis revisited: structure elucidation and metabolic engineering.Antiplasmodial drug targets: a patent review (2000 - 2013).Sunflower (Helianthus annuus) fatty acid synthase complex: β-hydroxyacyl-[acyl carrier protein] dehydratase genes.Deletion of fabN in Enterococcus faecalis results in unsaturated fatty acid auxotrophy and decreased release of inflammatory cytokines.Dehydratase-specific probes for fatty acid and polyketide synthases.A high yield optimized method for the production of acylated ACPs enabling the analysis of enzymes involved in P. falciparum fatty acid biosynthesis.Kinetic, inhibition and structural studies on 3-oxoacyl-ACP reductase from Plasmodium falciparum, a key enzyme in fatty acid biosynthesis.Benzothiophene carboxamide derivatives as inhibitors of Plasmodium falciparum enoyl-ACP reductase.Docking and in silico ADMET studies of noraristeromycin, curcumin and its derivatives with Plasmodium falciparum SAH hydrolase: a molecular drug target against malaria.The structure of (3R)-hydroxyacyl-acyl carrier protein dehydratase (FabZ) from Pseudomonas aeruginosa.Proof of function of a putative 3-hydroxyacyl-acyl carrier protein dehydratase from higher plants by mass spectrometry of product formation.Deciphering the key residues in Plasmodium falciparum beta-ketoacyl acyl carrier protein reductase responsible for interactions with Plasmodium falciparum acyl carrier protein.Identification and Phenotypic Characterization of ZEBRA LEAF16 Encoding a β-Hydroxyacyl-ACP Dehydratase in Rice.Synthesis and Evaluation of Substituted Pyrazoles: Potential Antimalarials Targeting the Enoyl‐ACP Reductase of Plasmodium Falciparum
P2860
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P2860
Identification, characterization, and inhibition of Plasmodium falciparum beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ).
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Identification, characterizati ...... er protein dehydratase (FabZ).
@en
Identification, characterizati ...... er protein dehydratase (FabZ).
@nl
type
label
Identification, characterizati ...... er protein dehydratase (FabZ).
@en
Identification, characterizati ...... er protein dehydratase (FabZ).
@nl
prefLabel
Identification, characterizati ...... er protein dehydratase (FabZ).
@en
Identification, characterizati ...... er protein dehydratase (FabZ).
@nl
P2093
P2860
P921
P356
P1476
Identification, characterizati ...... er protein dehydratase (FabZ).
@en
P2093
Avadhesha Surolia
Gyanendra Kumar
Mili Kapoor
Namita Surolia
Rahul Modak
Sanjay Kumar
Shailendra Kumar Sharma
Shilpi Sharma
T N C Ramya
P2860
P304
45661-45671
P356
10.1074/JBC.M304283200
P407
P577
2003-08-20T00:00:00Z