The selectivity of visual arrestin for light-activated phosphorhodopsin is controlled by multiple nonredundant mechanisms.
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Arrestins: ubiquitous regulators of cellular signaling pathwaysThe structural basis of arrestin-mediated regulation of G-protein-coupled receptorsAnalyzing the roles of multi-functional proteins in cells: The case of arrestins and GRKsCrystal Structure of Arrestin-3 Reveals the Basis of the Difference in Receptor Binding Between Two Non-visual SubtypesAcidic amino acids flanking phosphorylation sites in the M2 muscarinic receptor regulate receptor phosphorylation, internalization, and interaction with arrestinsHow genetic errors in GPCRs affect their function: Possible therapeutic strategiesVisual arrestins in olfactory pathways of Drosophila and the malaria vector mosquito Anopheles gambiae.Purification and characterization of bovine cone arrestin (cArr).Control of rhodopsin's active lifetime by arrestin-1 expression in mammalian rods.Lessons from photoreceptors: turning off g-protein signaling in living cells.The effect of arrestin conformation on the recruitment of c-Raf1, MEK1, and ERK1/2 activationExperimental and computational studies of the desensitization process in the bovine rhodopsin-arrestin complex.Monomeric rhodopsin is sufficient for normal rhodopsin kinase (GRK1) phosphorylation and arrestin-1 bindingDifferential interaction of spin-labeled arrestin with inactive and active phosphorhodopsin.Robust self-association is a common feature of mammalian visual arrestin-1.Expression Analysis of Visual Arrestin gene during Ocular Development of Olive Flounder (Paralichthys olivaceus).Few residues within an extensive binding interface drive receptor interaction and determine the specificity of arrestin proteins.A single mutation in arrestin-2 prevents ERK1/2 activation by reducing c-Raf1 binding.The functional cycle of visual arrestins in photoreceptor cells.Manipulation of very few receptor discriminator residues greatly enhances receptor specificity of non-visual arrestinsEngineering visual arrestin-1 with special functional characteristicsVisual and both non-visual arrestins in their "inactive" conformation bind JNK3 and Mdm2 and relocalize them from the nucleus to the cytoplasm.Visual arrestin binding to microtubules involves a distinct conformational changeThe differential engagement of arrestin surface charges by the various functional forms of the receptor.Critical role of the central 139-loop in stability and binding selectivity of arrestin-1.Regulation of arrestin binding by rhodopsin phosphorylation level.Constitutively active rhodopsin mutants causing night blindness are effectively phosphorylated by GRKs but differ in arrestin-1 bindingLight-dependent redistribution of arrestin in vertebrate rods is an energy-independent process governed by protein-protein interactions.Arrestin-3 binds c-Jun N-terminal kinase 1 (JNK1) and JNK2 and facilitates the activation of these ubiquitous JNK isoforms in cells via scaffolding.The role of arrestin alpha-helix I in receptor binding.Functional map of arrestin-1 at single amino acid resolutionCustom-designed proteins as novel therapeutic tools? The case of arrestins.Synthetic biology with surgical precision: targeted reengineering of signaling proteins.Structural determinants of arrestin functionsβ-arrestins and G protein-coupled receptor trafficking.Overview of different mechanisms of arrestin-mediated signaling.Beyond traditional pharmacology: new tools and approaches.Direct binding of visual arrestin to microtubules determines the differential subcellular localization of its splice variants in rod photoreceptors.Hitchhiking on the heptahelical highway: structure and function of 7TM receptor complexes.Arrestin mobilizes signaling proteins to the cytoskeleton and redirects their activity.
P2860
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P2860
The selectivity of visual arrestin for light-activated phosphorhodopsin is controlled by multiple nonredundant mechanisms.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh-hant
name
The selectivity of visual arre ...... tiple nonredundant mechanisms.
@en
The selectivity of visual arre ...... tiple nonredundant mechanisms.
@nl
type
label
The selectivity of visual arre ...... tiple nonredundant mechanisms.
@en
The selectivity of visual arre ...... tiple nonredundant mechanisms.
@nl
prefLabel
The selectivity of visual arre ...... tiple nonredundant mechanisms.
@en
The selectivity of visual arre ...... tiple nonredundant mechanisms.
@nl
P2860
P356
P1476
The selectivity of visual arre ...... tiple nonredundant mechanisms.
@en
P2860
P304
15501-15506
P356
10.1074/JBC.273.25.15501
P407
P577
1998-06-01T00:00:00Z