The differential engagement of arrestin surface charges by the various functional forms of the receptor.
about
Arrestins: ubiquitous regulators of cellular signaling pathwaysAnalyzing the roles of multi-functional proteins in cells: The case of arrestins and GRKsCrystal Structure of Arrestin-3 Reveals the Basis of the Difference in Receptor Binding Between Two Non-visual SubtypesCrystal structure of pre-activated arrestin p44Opposing effects of inositol hexakisphosphate on rod arrestin and arrestin2 self-association.Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery.Progressive reduction of its expression in rods reveals two pools of arrestin-1 in the outer segment with different roles in photoresponse recovery.The effect of arrestin conformation on the recruitment of c-Raf1, MEK1, and ERK1/2 activationMonomeric rhodopsin is sufficient for normal rhodopsin kinase (GRK1) phosphorylation and arrestin-1 bindingDifferential interaction of spin-labeled arrestin with inactive and active phosphorhodopsin.Robust self-association is a common feature of mammalian visual arrestin-1.Few residues within an extensive binding interface drive receptor interaction and determine the specificity of arrestin proteins.Identification of arrestin-3-specific residues necessary for JNK3 kinase activationA single mutation in arrestin-2 prevents ERK1/2 activation by reducing c-Raf1 binding.The functional cycle of visual arrestins in photoreceptor cells.Role of receptor-attached phosphates in binding of visual and non-visual arrestins to G protein-coupled receptors.Manipulation of very few receptor discriminator residues greatly enhances receptor specificity of non-visual arrestinsDistinct loops in arrestin differentially regulate ligand binding within the GPCR opsin.Involvement of distinct arrestin-1 elements in binding to different functional forms of rhodopsinEngineering visual arrestin-1 with special functional characteristicsVisual arrestin binding to microtubules involves a distinct conformational changeBinding between a distal C-terminus fragment of cannabinoid receptor 1 and arrestin-2.Critical role of the central 139-loop in stability and binding selectivity of arrestin-1.Arrestin binds to different phosphorylated regions of the thyrotropin-releasing hormone receptor with distinct functional consequences.Functional map of arrestin binding to phosphorylated opsin, with and without agonist.Regulation of arrestin binding by rhodopsin phosphorylation level.How and why do GPCRs dimerize?The role of arrestin alpha-helix I in receptor binding.Custom-designed proteins as novel therapeutic tools? The case of arrestins.Synthetic biology with surgical precision: targeted reengineering of signaling proteins.Structural determinants of arrestin functionsUncovering missing pieces: duplication and deletion history of arrestins in deuterostomes.β-Arrestin biosensors reveal a rapid, receptor-dependent activation/deactivation cycleMutations in arrestin-3 differentially affect binding to neuropeptide Y receptor subtypesNonvisual arrestins function as simple scaffolds assembling the MKK4-JNK3α2 signaling complexPhosphorylation of the delta-opioid receptor regulates its beta-arrestins selectivity and subsequent receptor internalization and adenylyl cyclase desensitization.Arrestin mobilizes signaling proteins to the cytoskeleton and redirects their activity.A model for the solution structure of the rod arrestin tetramer.Structural evidence for the role of polar core residue Arg175 in arrestin activation.Targeting individual GPCRs with redesigned nonvisual arrestins.
P2860
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P2860
The differential engagement of arrestin surface charges by the various functional forms of the receptor.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
The differential engagement of ...... ctional forms of the receptor.
@ast
The differential engagement of ...... ctional forms of the receptor.
@en
type
label
The differential engagement of ...... ctional forms of the receptor.
@ast
The differential engagement of ...... ctional forms of the receptor.
@en
prefLabel
The differential engagement of ...... ctional forms of the receptor.
@ast
The differential engagement of ...... ctional forms of the receptor.
@en
P2860
P356
P1476
The differential engagement of ...... ctional forms of the receptor.
@en
P2093
Susan M Hanson
Vsevolod V Gurevich
P2860
P304
P356
10.1074/JBC.M512148200
P407
P577
2005-12-08T00:00:00Z