A novel mechanism of pore formation: membrane penetration by the N-terminal amphipathic region of equinatoxin.
about
Membrane damage by an α-helical pore-forming protein, Equinatoxin II, proceeds through a succession of ordered stepsSolution NMR analysis of the interaction between the actinoporin sticholysin I and DHPC micelles--correlation with backbone dynamics.Imaging the lipid-phase-dependent pore formation of equinatoxin II in droplet interface bilayers.Functional characterization of sticholysin I and W111C mutant reveals the sequence of the actinoporin's pore assemblyCharacterization of the Lipid-Binding Site of Equinatoxin II by NMR and Molecular Dynamics SimulationInfrared spectroscopy study on the conformational changes leading to pore formation of the toxin sticholysin II.Evolution of the Cytolytic Pore-Forming Proteins (Actinoporins) in Sea Anemones.Membrane-active peptides from marine organisms--antimicrobials, cell-penetrating peptides and peptide toxins: applications and prospects.Oligomerization and pore formation by equinatoxin II inhibit endocytosis and lead to plasma membrane reorganization.Equinatoxin II permeabilizing activity depends on the presence of sphingomyelin and lipid phase coexistenceMultiomics analysis of the giant triton snail salivary gland, a crown-of-thorns starfish predator.Mutagenesis and functional analysis of the pore-forming toxin HALT-1 from Hydra magnipapillata.Toxicity of an α-pore-forming toxin depends on the assembly mechanism on the target membrane as revealed by single molecule imaging.Engineered covalent leucotoxin heterodimers form functional pores: insights into S-F interactions.A toxin-based probe reveals cytoplasmic exposure of Golgi sphingomyelinThe effect of cholesterol on the long-range network of interactions established among sea anemone Sticholysin II residues at the water-membrane interfaceMembrane binding of zebrafish actinoporin-like protein: AF domains, a novel superfamily of cell membrane binding domains.Membrane insertion of the N-terminal alpha-helix of equinatoxin II, a sea anemone cytolytic toxin.Crystallization and preliminary crystallographic analysis of fragaceatoxin C, a pore-forming toxin from the sea anemone Actinia fragacea.Pore formation by equinatoxin II, a eukaryotic protein toxin, occurs by induction of nonlamellar lipid structures.Identification and characterization of an amphipathic leucine zipper-like motif in Escherichia coli toxin hemolysin E. Plausible role in the assembly and membrane destabilization.Pore formation by equinatoxin, a eukaryotic pore-forming toxin, requires a flexible N-terminal region and a stable beta-sandwich.The membranotropic activity of N-terminal peptides from the pore-forming proteins sticholysin I and II is modulated by hydrophobic and electrostatic interactions as well as lipid composition.Effect of branched-chain fatty acid on lipid dynamics in mice lacking liver fatty acid binding protein gene.Biophysical and biochemical strategies to understand membrane binding and pore formation by sticholysins, pore-forming proteins from a sea anemone.Lipid phase coexistence favors membrane insertion of equinatoxin-II, a pore-forming toxin from Actinia equina.The chemical armament of reef-building corals: inter- and intra-specific variation and the identification of an unusual actinoporin in Stylophora pistilata.The active protein-conducting channel of Escherichia coli contains an apolar patch.Self-homodimerization of an actinoporin by disulfide bridging reveals implications for their structure and pore formation.Multigene Family of Pore-Forming Toxins from Sea Anemone Heteractis crispa.p-Sulfonato-calix[n]arenes inhibit staphylococcal bicomponent leukotoxins by supramolecular interactionsThe equinatoxin N-terminus is transferred across planar lipid membranes and helps to stabilize the transmembrane pore
P2860
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P2860
A novel mechanism of pore formation: membrane penetration by the N-terminal amphipathic region of equinatoxin.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
A novel mechanism of pore form ...... ipathic region of equinatoxin.
@en
A novel mechanism of pore form ...... ipathic region of equinatoxin.
@nl
type
label
A novel mechanism of pore form ...... ipathic region of equinatoxin.
@en
A novel mechanism of pore form ...... ipathic region of equinatoxin.
@nl
prefLabel
A novel mechanism of pore form ...... ipathic region of equinatoxin.
@en
A novel mechanism of pore form ...... ipathic region of equinatoxin.
@nl
P2093
P2860
P50
P356
P1476
A novel mechanism of pore form ...... ipathic region of equinatoxin.
@en
P2093
Gianfranco Menestrina
Petra Malovrh
Zdravko Podlesek
P2860
P304
22678-22685
P356
10.1074/JBC.M300622200
P407
P577
2003-04-02T00:00:00Z