Crystal Structure of a Human K-Ras G12D Mutant in Complex with GDP and the Cyclic Inhibitory Peptide KRpep-2d.

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Crystal Structure of a Human K-Ras G12D Mutant in Complex with GDP and the Cyclic Inhibitory Peptide KRpep-2d.

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2017 nî lūn-bûn

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2017年の論文

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年學術文章

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Crystal Structure of a Human K ...... c Inhibitory Peptide KRpep-2d.

@en

Crystal Structure of a Human K ...... c Inhibitory Peptide KRpep-2d.

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Item

label

Crystal Structure of a Human K ...... c Inhibitory Peptide KRpep-2d.

@en

Crystal Structure of a Human K ...... c Inhibitory Peptide KRpep-2d.

@nl

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Crystal Structure of a Human K ...... c Inhibitory Peptide KRpep-2d.

@en

Crystal Structure of a Human K ...... c Inhibitory Peptide KRpep-2d.

@nl

P1476

Crystal Structure of a Human K ...... ic Inhibitory Peptide KRpep-2d

@en

P2093

Jun-Ichi Sakamoto

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Kazuko Yonemori

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Kotaro Sakamoto

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Masahiro Kamaura

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Masanori Miwa

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Shigekazu Sasaki

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Tomoya Sameshima

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Yusuke Kamada

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Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange

Allosteric effects of the oncogenic RasQ61L mutant on Raf-RBD

Small molecule binding sites on the Ras:SOS complex can be exploited for inhibition of Ras activation

Selective Inhibition of Oncogenic KRAS Output with Small Molecules Targeting the Inactive State

P304

732-736

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P31

scholarly article

P356

10.1021/ACSMEDCHEMLETT.7B00128

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P433

http://www.w3.org/2001/XMLSchema#string

P478

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P50

Ayumu Niida

Satoshi Sogabe

P577

2017-05-10T00:00:00Z

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28740607

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5512123

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