Tissue- and age-specific DNA replication patterns at the CTG/CAG-expanded human myotonic dystrophy type 1 locus. - Wikidata - wikimedia - TriplyDB

Tissue- and age-specific DNA replication patterns at the CTG/CAG-expanded human myotonic dystrophy type 1 locus.

Tissue- and age-specific DNA replication patterns at the CTG/CAG-expanded human myotonic dystrophy type 1 locus.

http://www.wikidata.org/entity/Q48089467

about

Role of CTCF protein in regulating FMR1 locus transcription Repeat associated non-ATG translation initiation: one DNA, two transcripts, seven reading frames, potentially nine toxic entities!Interrogating the "unsequenceable" genomic trinucleotide repeat disorders by long-read sequencing Expanded CTG repeat demarcates a boundary for abnormal CpG methylation in myotonic dystrophy patient tissues Bidirectional transcription stimulates expansion and contraction of expanded (CTG)*(CAG) repeats.MSH3 polymorphisms and protein levels affect CAG repeat instability in Huntington's disease mice Mapping replication origin sequences in eukaryotic chromosomes.Hypermethylation of repeat expanded C9orf72 is a clinical and molecular disease modifier.Characterization of constitutive CTCF/cohesin loci: a possible role in establishing topological domains in mammalian genomes.Detection of slipped-DNAs at the trinucleotide repeats of the myotonic dystrophy type I disease locus in patient tissues.Highly specific contractions of a single CAG/CTG trinucleotide repeat by TALEN in yeast.Chromatin insulators: a role in nuclear organization and gene expression.Regulation of recombination at yeast nuclear pores controls repair and triplet repeat stability.Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins.Repeat instability during DNA repair: Insights from model systems Instability of (CTG)n•(CAG)n trinucleotide repeats and DNA synthesis Altered replication in human cells promotes DMPK (CTG)(n) · (CAG)(n) repeat instability The nucleotide sequence, DNA damage location, and protein stoichiometry influence the base excision repair outcome at CAG/CTG repeats ORC proteins in the mammalian zygote Absence of MutSβ leads to the formation of slipped-DNA for CTG/CAG contractions at primate replication forks.Transcriptionally Repressive Chromatin Remodelling and CpG Methylation in the Presence of Expanded CTG-Repeats at the DM1 Locus.The DNA replication program is altered at the FMR1 locus in fragile X embryonic stem cells.Impact of bulge loop size on DNA triplet repeat domains: Implications for DNA repair and expansion.Abnormal base excision repair at trinucleotide repeats associated with diseases: a tissue-selective mechanism.Expression levels of DNA replication and repair genes predict regional somatic repeat instability in the brain but are not altered by polyglutamine disease protein expression or age.To switch or not to switch: at the origin of repeat expansion disease.Expanding the roles of chromatin insulators in nuclear architecture, chromatin organization and genome function.Recombinational DNA repair is regulated by compartmentalization of DNA lesions at the nuclear pore complex.CpG Methylation, a Parent-of-Origin Effect for Maternal-Biased Transmission of Congenital Myotonic Dystrophy Relocalization of DNA lesions to the nuclear pore complex.Myotonic Dystrophy Type 1 Management and Therapeutics.Myotonic dystrophy type 1: role of CCG, CTC and CGG interruptions within DMPK alleles in the pathogenesis and molecular diagnosis.Myotonic dystrophy: disease repeat range, penetrance, age of onset, and relationship between repeat size and phenotypes.Role of recombination and replication fork restart in repeat instability.Molecular, clinical, and muscle studies in myotonic dystrophy type 1 (DM1) associated with novel variant CCG expansions.Somatic instability of CTG repeats in the cerebellum of myotonic dystrophy type 1.Oligonucleotide cyclization: the thiol-maleimide reaction revisited.Insulation of tumor suppressor genes by the nuclear factor CTCF.

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Tissue- and age-specific DNA replication patterns at the CTG/CAG-expanded human myotonic dystrophy type 1 locus.

http://www.wikidata.org/entity/Q48089467

description

2010 nî lūn-bûn

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2010年の論文

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年學術文章

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2010年學術文章

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name

Tissue- and age-specific DNA r ...... otonic dystrophy type 1 locus.

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Tissue- and age-specific DNA r ...... otonic dystrophy type 1 locus.

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type

label

Tissue- and age-specific DNA r ...... otonic dystrophy type 1 locus.

@en

Tissue- and age-specific DNA r ...... otonic dystrophy type 1 locus.

@nl

prefLabel

Tissue- and age-specific DNA r ...... otonic dystrophy type 1 locus.

@en

Tissue- and age-specific DNA r ...... otonic dystrophy type 1 locus.

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Nature Structural & Molecular Biology

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Tissue- and age-specific DNA r ...... yotonic dystrophy type 1 locus

@en

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Arturo López Castel

http://www.w3.org/2001/XMLSchema#string

Christopher E Pearson

http://www.w3.org/2001/XMLSchema#string

David Chitayat

http://www.w3.org/2001/XMLSchema#string

Gagan B Panigrahi

http://www.w3.org/2001/XMLSchema#string

Hana Sroka

http://www.w3.org/2001/XMLSchema#string

John D Cleary

http://www.w3.org/2001/XMLSchema#string

Katharine A Hagerman

http://www.w3.org/2001/XMLSchema#string

Laurent Foiry

http://www.w3.org/2001/XMLSchema#string

Stéphanie Tomé

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Cohesin acetylation speeds the replication fork

CTCF physically links cohesin to chromatin

BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma.

A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands

Mapping of an origin of DNA replication in the promoter of fragile X gene FMR1

CTCF regulates asynchronous replication of the imprinted H19/Igf2 domain

Isolated short CTG/CAG DNA slip-outs are repaired efficiently by hMutSbeta, but clustered slip-outs are poorly repaired.

Distal sequences, but not ori-beta/OBR-1, are essential for initiation of DNA replication in the Chinese hamster DHFR origin.

Transgenic mice carrying large human genomic sequences with expanded CTG repeat mimic closely the DM CTG repeat intergenerational and somatic instability.

CTCF cis-regulates trinucleotide repeat instability in an epigenetic manner: a novel basis for mutational hot spot determination.

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1079-1087

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scholarly article

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10.1038/NSMB.1876

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9

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17

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Genevieve Gourdon

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2010-08-15T00:00:00Z

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45651098

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20711191

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