Disruption of the presynaptic cytomatrix protein bassoon degrades ribbon anchorage, multiquantal release, and sound encoding at the hair cell afferent synapse.
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Role of Bassoon and Piccolo in Assembly and Molecular Organization of the Active ZoneModeling auditory coding: from sound to spikesRab3-interacting molecules 2α and 2β promote the abundance of voltage-gated CaV1.3 Ca2+ channels at hair cell active zonesDual-color STED microscopy reveals a sandwich structure of Bassoon and Piccolo in active zones of adult and aged mice.New insights into cochlear sound encodingCochlear Synaptopathy and Noise-Induced Hidden Hearing Loss.Ribbon synapse plasticity in the cochleae of Guinea pigs after noise-induced silent damageA system for studying mechanisms of neuromuscular junction development and maintenanceHair cells use active zones with different voltage dependence of Ca2+ influx to decompose sounds into complementary neural codes.Cochlear hair cells: The sound-sensing machines.Coding Deficits in Noise-Induced Hidden Hearing Loss May Stem from Incomplete Repair of Ribbon Synapses in the Cochlea.Relating structure and function of inner hair cell ribbon synapses.EF-hand protein Ca2+ buffers regulate Ca2+ influx and exocytosis in sensory hair cellsChanges of ribbon synapses number of cochlear hair cells in C57BL/6J mice with age(Δ).Presynaptic active zones in invertebrates and vertebrates.Ribbon synapses in zebrafish hair cells.Disruption of adaptor protein 2μ (AP-2μ) in cochlear hair cells impairs vesicle reloading of synaptic release sites and hearing.A synaptic F-actin network controls otoferlin-dependent exocytosis in auditory inner hair cells.Thyroid hormone is required for pruning, functioning and long-term maintenance of afferent inner hair cell synapses.How to make a synaptic ribbon: RIBEYE deletion abolishes ribbons in retinal synapses and disrupts neurotransmitter release.Macromolecular complexes at active zones: integrated nano-machineries for neurotransmitter release.Voltage-gated K(+) channels contributing to temporal precision at the inner hair cell-auditory afferent nerve fiber synapses in the mammalian cochlea.Resolving the structure of inner ear ribbon synapses with STED microscopy.Basic response properties of auditory nerve fibers: a review.Bassoon-disruption slows vesicle replenishment and induces homeostatic plasticity at a CNS synapse.Spaceflight-induced synaptic modifications within hair cells of the mammalian utricle.Vertebrate Presynaptic Active Zone Assembly: a Role Accomplished by Diverse Molecular and Cellular Mechanisms.The BEACH protein LRBA is required for hair bundle maintenance in cochlear hair cells and for hearing.Ca2+-binding protein 2 inhibits Ca2+-channel inactivation in mouse inner hair cells.Tryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and hearing.Hair cell synaptic dysfunction, auditory fatigue and thermal sensitivity in otoferlin Ile515Thr mutants.Ca2+-Permeable AMPARs Mediate Glutamatergic Transmission and Excitotoxic Damage at the Hair Cell Ribbon Synapse.RIM-Binding Protein 2 Promotes a Large Number of CaV1.3 Ca2+-Channels and Contributes to Fast Synaptic Vesicle Replenishment at Hair Cell Active Zones.Piccolo Promotes Vesicle Replenishment at a Fast Central Auditory Synapse.The presynaptic scaffolding protein Piccolo organizes the readily releasable pool at the calyx of Held.Otoferlin acts as a Ca2+ sensor for vesicle fusion and vesicle pool replenishment at auditory hair cell ribbon synapses.The synaptic ribbon is critical for sound encoding at high rates and with temporal precision.The presynaptic ribbon maintains vesicle populations at the hair cell afferent fiber synapse.Otoferlin is a multivalent calcium-sensitive scaffold linking SNAREs and calcium channels.Clarin-1 gene transfer rescues auditory synaptopathy in model of Usher syndrome
P2860
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P2860
Disruption of the presynaptic cytomatrix protein bassoon degrades ribbon anchorage, multiquantal release, and sound encoding at the hair cell afferent synapse.
description
2013 nî lūn-bûn
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2013年の論文
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2013年学术文章
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2013年学术文章
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2013年学术文章
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2013年学术文章
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2013年学术文章
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2013年学术文章
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name
Disruption of the presynaptic ...... he hair cell afferent synapse.
@en
Disruption of the presynaptic ...... he hair cell afferent synapse.
@nl
type
label
Disruption of the presynaptic ...... he hair cell afferent synapse.
@en
Disruption of the presynaptic ...... he hair cell afferent synapse.
@nl
prefLabel
Disruption of the presynaptic ...... he hair cell afferent synapse.
@en
Disruption of the presynaptic ...... he hair cell afferent synapse.
@nl
P2093
P50
P1476
Disruption of the presynaptic ...... the hair cell afferent synapse
@en
P2093
Darina Khimich
Nicola Strenzke
Thomas Frank
Zhizi Jing
P304
P356
10.1523/JNEUROSCI.3491-12.2013
P407
P577
2013-03-01T00:00:00Z