Human BRCA1-BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection.
about
Repair of DNA Double-Strand Breaks in HeterochromatinControlling DNA-End Resection: An Emerging Task for Ubiquitin and SUMOFunctional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistanceTumors overexpressing RNF168 show altered DNA repair and responses to genotoxic treatments, genomic instability and resistance to proteotoxic stress.BRCA1 recruitment to damaged DNA sites is dependent on CDK9.The control of DNA repair by the cell cycle.The BRCA1 Ubiquitin ligase function sets a new trend for remodelling in DNA repair.Therapeutic targeting and patient selection for cancers with homologous recombination defects.RAP80, ubiquitin and SUMO in the DNA damage response.DNA repair goes hip-hop: SMARCA and CHD chromatin remodellers join the break dance.And yet, it moves: nuclear and chromatin dynamics of a heterochromatic double-strand break.Targeting of the Fun30 nucleosome remodeller by the Dpb11 scaffold facilitates cell cycle-regulated DNA end resection.53BP1 and BRCA1 control pathway choice for stalled replication restart.PARP2 controls double-strand break repair pathway choice by limiting 53BP1 accumulation at DNA damage sites and promoting end-resection.ATM and CDK2 control chromatin remodeler CSB to inhibit RIF1 in DSB repair pathway choice.The CUE1 domain of the SNF2-like chromatin remodeler SMARCAD1 mediates its association with KRAB-associated protein 1 (KAP1) and KAP1 target genes.H4K20me2 distinguishes pre-replicative from post-replicative chromatin to appropriately direct DNA repair pathway choice by 53BP1-RIF1-MAD2L2.BARD1 is necessary for ubiquitylation of nucleosomal histone H2A and for transcriptional regulation of estrogen metabolism genes.Nup153 and Nup50 promote recruitment of 53BP1 to DNA repair foci by antagonizing BRCA1-dependent events.USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A.mRNA Processing Factor CstF-50 and Ubiquitin Escort Factor p97 Are BRCA1/BARD1 Cofactors Involved in Chromatin Remodeling during the DNA Damage Response.BRCA1-BARD1 promotes RAD51-mediated homologous DNA pairing.How cells ensure correct repair of DNA double-strand breaks.Reading chromatin signatures after DNA double-strand breaks.Tuning BRCA1 and BARD1 activity to investigate RING ubiquitin ligase mechanisms.DNA repair and cell cycle checkpoint defects in a mouse model of 'BRCAness' are partially rescued by 53BP1 deletion.SUMO, a small, but powerful, regulator of double-strand break repair.FAM35A associates with REV7 and modulates DNA damage responses of normal and BRCA1-defective cells.Shepherding DNA ends: Rif1 protects telomeres and chromosome breaks.Nucleosomes around a mismatched base pair are excluded via an Msh2-dependent reaction with the aid of SNF2 family ATPase Smarcad1Homology-Directed Repair and the Role of BRCA1, BRCA2, and Related Proteins in Genome Integrity and CancerBRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance
P2860
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P2860
Human BRCA1-BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年学术文章
@wuu
2016年学术文章
@zh
2016年学术文章
@zh-cn
2016年学术文章
@zh-hans
2016年学术文章
@zh-my
2016年学术文章
@zh-sg
2016年學術文章
@yue
2016年學術文章
@zh-hant
name
Human BRCA1-BARD1 ubiquitin li ...... tin barriers to DNA resection.
@en
Human BRCA1-BARD1 ubiquitin li ...... tin barriers to DNA resection.
@nl
type
label
Human BRCA1-BARD1 ubiquitin li ...... tin barriers to DNA resection.
@en
Human BRCA1-BARD1 ubiquitin li ...... tin barriers to DNA resection.
@nl
prefLabel
Human BRCA1-BARD1 ubiquitin li ...... tin barriers to DNA resection.
@en
Human BRCA1-BARD1 ubiquitin li ...... tin barriers to DNA resection.
@nl
P2093
P2860
P50
P356
P1476
Human BRCA1-BARD1 ubiquitin li ...... tin barriers to DNA resection.
@en
P2093
Alexander J Garvin
Alice Fletcher
Balraj Johal
Felicity Z Watts
Helen R Stone
James Beesley
Joanna Strachan
Sarah Blair-Reid
P2860
P2888
P304
P356
10.1038/NSMB.3236
P50
P577
2016-05-30T00:00:00Z