Immunopositivity for ESCRT-III subunit CHMP2B in granulovacuolar degeneration of neurons in the Alzheimer's disease hippocampus.
about
Neuropathological alterations in Alzheimer diseaseGranulovacuolar degenerations appear in relation to hippocampal phosphorylated tau accumulation in various neurodegenerative disorders.Granulovacuolar degeneration (GVD) bodies of Alzheimer's disease (AD) resemble late-stage autophagic organelles.Phosphatidylinositol-4,5-bisphosphate is enriched in granulovacuolar degeneration bodies and neurofibrillary tanglesMolecular markers for granulovacuolar degeneration are present in rimmed vacuoles.Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover.Neuronal Functions of ESCRTsFrontotemporal dementia-associated N279K tau mutant disrupts subcellular vesicle trafficking and induces cellular stress in iPSC-derived neural stem cells.Potential contribution of exosomes to the prion-like propagation of lesions in Alzheimer's disease.A novel origin for granulovacuolar degeneration in aging and Alzheimer's disease: parallels to stress granules.α-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy body disease.ESCRT-0 dysfunction compromises autophagic degradation of protein aggregates and facilitates ER stress-mediated neurodegeneration via apoptotic and necroptotic pathways.Antimicrobial peptide β-defensin-1 expression is upregulated in Alzheimer's brainLysosomal fusion dysfunction as a unifying hypothesis for Alzheimer's disease pathology.Brain pathology in myotonic dystrophy: when tauopathy meets spliceopathy and RNAopathy.Granulovacuolar degeneration: a neurodegenerative change that accompanies tau pathology.Granulovacuolar Degeneration in Hippocampus of Neurodegenerative Diseases: Quantitative Study.Aβ accumulation causes MVB enlargement and is modelled by dominant negative VPS4A.Pathology of clinical and preclinical Alzheimer's disease.Localization of CHMP2B-immunoreactivity in the brainstem of Lewy body disease.Stages of granulovacuolar degeneration: their relation to Alzheimer's disease and chronic stress response.Dysfunction of autophagy and endosomal-lysosomal pathways: Roles in pathogenesis of Down syndrome and Alzheimer's Disease.Autophagy and Alzheimer's Disease: From Molecular Mechanisms to Therapeutic Implications.Rare autosomal copy number variations in early-onset familial Alzheimer's disease.The identification of raft-derived tau-associated vesicles that are incorporated into immature tangles and paired helical filaments.The Impact of ESCRT on Aβ Induced Membrane Lesions in a Yeast Model for Alzheimer's Disease
P2860
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P2860
Immunopositivity for ESCRT-III subunit CHMP2B in granulovacuolar degeneration of neurons in the Alzheimer's disease hippocampus.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh-hant
name
Immunopositivity for ESCRT-III ...... zheimer's disease hippocampus.
@en
Immunopositivity for ESCRT-III ...... zheimer's disease hippocampus.
@nl
type
label
Immunopositivity for ESCRT-III ...... zheimer's disease hippocampus.
@en
Immunopositivity for ESCRT-III ...... zheimer's disease hippocampus.
@nl
prefLabel
Immunopositivity for ESCRT-III ...... zheimer's disease hippocampus.
@en
Immunopositivity for ESCRT-III ...... zheimer's disease hippocampus.
@nl
P2093
P1433
P1476
Immunopositivity for ESCRT-III ...... lzheimer's disease hippocampus
@en
P2093
Masanori Hiji
Masayasu Matsumoto
Takemori Yamawaki
Tetsuya Takahashi
Yuishin Izumi
P356
10.1016/J.NEULET.2010.04.038
P407
P577
2010-04-24T00:00:00Z