Proteasome inhibition alleviates SNARE-dependent neurodegeneration.
about
Ubiquitin-Synaptobrevin Fusion Protein Causes Degeneration of Presynaptic Motor Terminals in MiceSynaptic vesicle recycling: steps and principlesActivity-Dependent Degradation of Synaptic Vesicle Proteins Requires Rab35 and the ESCRT PathwayCaenorhabditis elegans dnj-14, the orthologue of the DNAJC5 gene mutated in adult onset neuronal ceroid lipofuscinosis, provides a new platform for neuroprotective drug screening and identifies a SIR-2.1-independent action of resveratrol.Ethosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expressionThe Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative DiseasesIncreased Expression of the Large Conductance, Calcium-Activated K+ (BK) Channel in Adult-Onset Neuronal Ceroid Lipofuscinosisβ-Amyloid and α-synuclein cooperate to block SNARE-dependent vesicle fusionIncreased SNARE Protein-Protein Interactions in Orbitofrontal and Anterior Cingulate Cortices in SchizophreniaExpression profile of a Caenorhabditis elegans model of adult neuronal ceroid lipofuscinosis reveals down regulation of ubiquitin E3 ligase components.Loss of Munc18-1 long splice variant in GABAergic terminals is associated with cognitive decline and increased risk of dementia in a community sampleTraumatic Brain Injury Impairs Soluble N-Ethylmaleimide-Sensitive Factor Attachment Protein Receptor Complex Formation and Alters Synaptic Vesicle Distribution in the Hippocampus.Cowden syndrome-related mutations in PTEN associate with enhanced proteasome activity.Blood RNA profiling in a large cohort of multiple sclerosis patients and healthy controls.Lysosomal dysfunction disrupts presynaptic maintenance and restoration of presynaptic function prevents neurodegeneration in lysosomal storage diseases.CSPα-chaperoning presynaptic proteins.The molecular machinery of neurotransmitter release (Nobel lecture).Cysteine string protein (CSP) and its role in preventing neurodegeneration.Primary fibroblasts from CSPα mutation carriers recapitulate hallmarks of the adult onset neuronal ceroid lipofuscinosis.Molecular changes in the postmortem parkinsonian brain.CSPα, a Molecular Co-chaperone Essential for Short and Long-Term Synaptic Maintenance.Synaptic Vesicle-Recycling Machinery Components as Potential Therapeutic Targets.Silencing synapses: a route to understanding synapse degeneration in chronic neurodegenerative disease.Neurons Export Extracellular Vesicles Enriched in Cysteine String Protein and Misfolded Protein Cargo.Amyloid-β Oligomers May Impair SNARE-Mediated Exocytosis by Direct Binding to Syntaxin 1a.The ubiquitin-proteasome system functionally links neuronal Tomosyn-1 to dendritic morphology.
P2860
Q26269823-A4A344FA-9C5B-4BDE-AB6E-F5F3386396A0Q26825177-A6BF7FD6-9630-4B19-AFF7-DA44E368A90CQ28830156-DBCA1F0B-A85B-4D8F-A1D2-5F8976501201Q30594778-093A0C9E-1591-4A2A-AA7E-244C7E812952Q30666205-5892F18A-25B6-48E8-B3CD-D07336544F60Q33692255-DCCE9279-093E-4FA8-A51E-0595A99B6B8CQ35532437-DD4D0232-ACE2-49A2-AF9C-C149751166AFQ35551615-5A755401-B072-4E90-8B76-AECDAC3B5D49Q35761611-0B1E4FA5-8050-41AC-839C-F482C8E3F036Q36099459-4E6A42DC-288E-4EA3-9C53-2F9B22A4D138Q36341076-41513CEB-3C27-40FA-AC5C-4E1B8DC078EEQ36427694-C9FF5AE3-E80F-4603-9910-4D29BAD2508EQ36847305-278D7F1E-AF4F-4CE2-AB86-1BEDDC2D2BD1Q37193914-DAC35998-B3D3-4DBB-82C5-59C8DCC99FB8Q37555645-EF1DB770-5F2A-4792-9220-A05F64FBE17BQ38210203-D35CEE0E-AFC5-4F7E-B684-B233CAF696A6Q38262070-F05FC148-FBF2-447A-A4C0-932282681D2DQ38388009-3DCBBBF2-67F7-479B-82DB-84783B837278Q38663518-C76F1478-870D-412D-9FAB-A7582E02A1EBQ38887346-BFC3B86F-1D43-4862-A18D-67A81D13A98AQ39151927-0B3B4436-7972-4CF5-8DB1-2AAE7FBDEACEQ39164408-A37B814B-E8E0-4303-B6DA-E7DB3F5A04AFQ39332908-D2A6DF12-5717-4093-A929-DB6F76AD058BQ42269174-D8E737C1-67A4-4627-8866-9C7910EFC02AQ42409562-989CBF5A-2618-4F37-AC6E-A81AEFC4F564Q47263177-A06CCDE0-63AD-43DD-B0AF-107363EDF3EC
P2860
Proteasome inhibition alleviates SNARE-dependent neurodegeneration.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh-hant
name
Proteasome inhibition alleviates SNARE-dependent neurodegeneration.
@en
Proteasome inhibition alleviates SNARE-dependent neurodegeneration.
@nl
type
label
Proteasome inhibition alleviates SNARE-dependent neurodegeneration.
@en
Proteasome inhibition alleviates SNARE-dependent neurodegeneration.
@nl
prefLabel
Proteasome inhibition alleviates SNARE-dependent neurodegeneration.
@en
Proteasome inhibition alleviates SNARE-dependent neurodegeneration.
@nl
P2860
P1476
Proteasome inhibition alleviates SNARE-dependent neurodegeneration.
@en
P2093
Manu Sharma
P2860
P304
P356
10.1126/SCITRANSLMED.3004028
P407
P577
2012-08-01T00:00:00Z