Cocaine esterase: interactions with cocaine and immune responses in mice.
about
Most efficient cocaine hydrolase designed by virtual screening of transition statesLong-acting cocaine hydrolase for addiction therapyA Thermally Stable Form of Bacterial Cocaine Esterase: A Potential Therapeutic Agent for Treatment of Cocaine AbuseStructural analysis of thermostabilizing mutations of cocaine esteraseSubunit Stabilization and Polyethylene Glycolation of Cocaine Esterase Improves In Vivo Residence TimeRational Design, Preparation, and Characterization of a Therapeutic Enzyme Mutant with Improved Stability and Function for Cocaine DetoxificationA cocaine hydrolase engineered from human butyrylcholinesterase selectively blocks cocaine toxicity and reinstatement of drug seeking in rats.PEGylation of bacterial cocaine esterase for protection against protease digestion and immunogenicityAccelerating cocaine metabolism as an approach to the treatment of cocaine abuse and toxicityNovel pharmacological approaches to treatment of drug overdose and addictionDesign, preparation, and characterization of high-activity mutants of human butyrylcholinesterase specific for detoxification of cocaine.Amelioration of the cardiovascular effects of cocaine in rhesus monkeys by a long-acting mutant form of cocaine esterase.Thermostable variants of cocaine esterase for long-time protection against cocaine toxicityEffects of a long-acting mutant bacterial cocaine esterase on acute cocaine toxicity in rats.Enzyme-therapy approaches for the treatment of drug overdose and addiction.Evaluation of the hydrolytic activity of a long-acting mutant bacterial cocaine in the presence of commonly co-administered drugs.The fate of bacterial cocaine esterase (CocE): an in vivo study of CocE-mediated cocaine hydrolysis, CocE pharmacokinetics, and CocE elimination.Bacterial cocaine esterase: a protein-based therapy for cocaine overdose and addictionLong-lasting effects of a PEGylated mutant cocaine esterase (CocE) on the reinforcing and discriminative stimulus effects of cocaine in rats.A bacterial cocaine esterase protects against cocaine-induced epileptogenic activity and lethality.Repeated administration of a mutant cocaine esterase: effects on plasma cocaine levels, cocaine-induced cardiovascular activity, and immune responses in rhesus monkeys.An albumin-butyrylcholinesterase for cocaine toxicity and addiction: catalytic and pharmacokinetic propertiesEffects of cocaine esterase following its repeated administration with cocaine in miceLasting reduction of cocaine action in neostriatum--a hydrolase gene therapy approachFundamental reaction mechanism and free energy profile for (-)-cocaine hydrolysis catalyzed by cocaine esteraseCocaine esterase prevents cocaine-induced toxicity and the ongoing intravenous self-administration of cocaine in rats.Recent progress in protein drug design and discovery with a focus on novel approaches to the development of anti-cocaine medications.Computational design of protein-ligand interfaces: potential in therapeutic development.Free energy profiles of cocaine esterase-cocaine binding process by molecular dynamics and potential of mean force simulations.Cocaine esterase-cocaine binding process and the free energy profiles by molecular dynamics and potential of mean force simulations.Computational design of a thermostable mutant of cocaine esterase via molecular dynamics simulations.Reaction mechanism for cocaine esterase-catalyzed hydrolyses of (+)- and (-)-cocaine: unexpected common rate-determining step.Prevention and reversal by cocaine esterase of cocaine-induced cardiovascular effects in rats.Clinical Potential of an Enzyme-based Novel Therapy for Cocaine Overdose.Pharmacokinetic approaches to treatment of drug addiction.
P2860
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P2860
Cocaine esterase: interactions with cocaine and immune responses in mice.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh-hant
name
Cocaine esterase: interactions with cocaine and immune responses in mice.
@en
Cocaine esterase: interactions with cocaine and immune responses in mice.
@nl
type
label
Cocaine esterase: interactions with cocaine and immune responses in mice.
@en
Cocaine esterase: interactions with cocaine and immune responses in mice.
@nl
prefLabel
Cocaine esterase: interactions with cocaine and immune responses in mice.
@en
Cocaine esterase: interactions with cocaine and immune responses in mice.
@nl
P2093
P356
P1476
Cocaine esterase: interactions with cocaine and immune responses in mice.
@en
P2093
Aaron A Berlin
Diwahar Narasimhan
James H Woods
Luvina D Bowen
Nicholas W Lukacs
Roger K Sunahara
P304
P356
10.1124/JPET.106.114223
P407
P577
2006-11-17T00:00:00Z